Job Description Summary
The laboratory of Dr. Strickland in the Department of Neurosurgery and Cancer Biology & Immunology at MUSC is recruiting a motivated post-doctoral fellow in the field of central nervous system immuno-oncology. The Strickland lab focuses on targeting immunosuppressive tumor associated macrophage (TAM) as a means of anti-tumor therapy against glioblastoma. The major theme is translating methods of TAM depletion, or reprogramming towards an anti-inflammatory phenotype, into clinical trial in Dr. Strickland’s busy clinical practice. Dr. Strickland’s laboratory leverages syngeneic animal models with high-throughput transcriptomic approaches to elucidate the complex glioblastoma microenvironment and develop targeted therapies. Studies will generally range from single cell/nuclei and spatial transcriptomics/proteomics, functional cell-based assays, mouse models, and human in-vitro cell culture. In this position, you will have the opportunity to develop and lead projects focused on targeting macrophages in glioblastoma with an emphasis on developing a novel target for CAR-T delivery. You will also gain experience and training in transcriptomics/proteomics, pre-clinical study development. As such, the ability to work with mouse models of cancer is essential. A successful post-doctoral research fellow would be expected to conduct high quality research for publication in high impact journals. Fellows would also be encouraged to apply for independent postdoctoral grants. The Fellow would be joining a laboratory with an experienced research technician III.
Entity
Medical University of South Carolina (MUSC - Univ)
Worker Type
Employee
Worker Sub-Type
Regular
Cost Center
CC000986 COM NSGY General CC
Pay Rate Type
Salary
Pay Grade
University-00
Pay Range
0.00 - 0.00 - 0.000
Scheduled Weekly Hours
40
Work Shift
Job Description
Job Duties:
35% - Develop and lead projects using several cutting-edge model systems including TAM depletion, TAM reprograming, and immune competent models of malignancy. Analyze data generated from these studies and prepare manuscript drafts and present at national conferences.
35% - Train in transcriptomics, flow cytometry, adoptive transfer biology, and pre-clinical development and preparation of IND enabling documents. Outcomes will lead to a publishable manuscript.
25% - Perform immunology techniques including ELISAs, flow-based cytokine determination, cellular proliferation, and cytotoxicity assays, conduct collaborative work on multi-institutional grants.
5% - Perform other essential duties as requested. These will include maintain animal colonies, collaborate with DLAR to provide the best animal care, update IACUC and IBC protocols, order supplies for the laboratory.
Additional Job Description
MUSC Minimum Training and Experience Requirements: PhD
Preferred Experience & Additional Skills: Successful applicants will have a Ph.D. or M.D./Ph.D. with substantial hands-on research experience in immuno-oncology. Candidates with prior experience in immunology, immunotherapy, tumor micro-environment, and cancer biology are highly desirable for this position. As this position will involve in vivo mouse models of glioblastoma, experience in techniques such as animal handling, drug administration, multicolor flow cytometry, ELISA, flow-based cytokine determination, cytometric bead array, TCR immune-sequencing, and cell-based bioassays are essential. A familiarity with handling large data sets to investigate immune pathways dysregulated in glioblastoma and immunotherapy-resistant tumors is also desirable. The candidate must be fluent in oral and written English, able to work independently and collaboratively, are well organized, proficient of proper scientific record keeping, be able to analyze and interpret/communicate data in a logical and timely manner. The ideal candidate will also be able to work with the fluctuating schedule of the neurosurgeon PI who commands a busy brain tumor center.
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent)
Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.
If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
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