Full-Time

Director Gene Editing Analytics and Strategy

Updated on 1/21/2025

Legend Biotech

Legend Biotech

1,001-5,000 employees

Develops and commercializes cell therapies

Biotechnology
Healthcare

Expert

Somerset County, NJ, USA

Hybrid position requiring in-office presence.

Category
Bioinformatics
Computational Biology
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis

You match the following Legend Biotech's candidate preferences

Employers are more likely to interview you if you match these preferences:

Degree
Experience
Requirements
  • PhD. in Molecular Biology, Genetics, Biochemistry, or a related field
  • 10+ years of industry experience in a biotech or pharmaceutical setting
  • Deep technical understanding of and hands-on experience with gene editing tools (e.g. CRISPR/Cas9, TALEN, ZFN, etc)
  • Strong background in mammalian cell culture, molecular biology assays, including nucleic acid isolation, amplicon sequencing, qPCR, ddPCR, bulk and single-cell NGS
  • A working ability with sequencing-related bioinformatics is a plus
  • Prior experience in CAR-T or related cell therapy development
  • Knowledge of T-cell biology and immunology is a plus
  • Expertise in analytical method development and validation
  • Knowledge of cGMP and ICH guidelines
  • Detail-oriented with expertise in problem solving and solid decision-making abilities
  • Excellent written, verbal, and collaboration skills are essential
  • Patient focus is a must
  • English and Mandarin are preferred
Responsibilities
  • Direct and execute the establishment of analytical methods for characterization of various gene manipulation methods including overexpression, knockdowns, knockouts and knockins
  • On a cross-functional team including non-clinical and regulatory colleagues, characterize edited cells using a comprehensive analytical toolbox to create a strong understanding of editing efficiency and the potential for unintended effects
  • Leverage characterization data to create a risk-based approach to product release, promoting relevant assays to release methods
  • Obtain regulatory feedback on characterization data and release approach to generate confidence in IND submissions
  • Guide the establish and authoring of SOPs/procedures for established methods
  • Direct the transfer of release methods to internal or external QC as appropriate
  • Provide feedback to product design teams regarding the design of gene edits
  • Guide the design and execution of method qualification
  • Participate in cross-functional project teams to advance products towards and through clinical trials
  • Stay current on the latest advancements in assay development and gene perturbation technologies and apply relevant knowledge to development projects
  • Work with technology development partners to advance sequencing-based technologies
  • Drive projects to meet established timelines while maintaining the highest quality and data integrity standards
  • Analyze data for trends and recommendations for scientific staff. Present analyzed data within and across departmental meetings
  • Provide analytical support for manufacturing and QC root cause investigations for OOS/OOE
  • Author and / or review technical documents, protocols and / or reports
  • Procure and qualify required materials to perform experiments or testing
  • Mentor or guide junior scientists with experimental design, data analysis and troubleshooting
  • Responsible for ensuring effective, accurate and timely communication of project information
Desired Qualifications
  • A working ability with sequencing-related bioinformatics is a plus
  • Prior experience in CAR-T or related cell therapy development
  • Knowledge of T-cell biology and immunology is a plus
  • English and Mandarin are preferred

Legend Biotech develops and commercializes cell therapies aimed at treating serious diseases, particularly cancers like hematological malignancies and solid tumors. Their approach is technology agnostic, allowing them to explore various methods to find effective treatments. The company operates in the personalized medicine sector, focusing on discovering, developing, and bringing new therapies to market. They generate revenue through licensing and selling their therapies, including CAR-T therapies, which involve modifying a patient's cells to combat cancer. Unlike many competitors, Legend Biotech emphasizes transparency with investors, regularly updating them on financial results and business developments. Their goal is to provide effective treatments for hard-to-treat diseases through innovative cell therapy solutions.

Company Stage

IPO

Total Funding

$146.4M

Headquarters

Franklin Township, New Jersey

Founded

2014

Growth & Insights
Headcount

6 month growth

0%

1 year growth

-1%

2 year growth

0%
Simplify Jobs

Simplify's Take

What believers are saying

  • Recent FDA and European approvals for CARVYKTI® expand its market reach in multiple myeloma.
  • New R&D facility in Philadelphia boosts innovation in next-generation cell therapies.
  • Alan Bash's appointment could accelerate CARVYKTI®'s growth and market penetration.

What critics are saying

  • Increased competition from Amgen's Imdelltra may impact CAR-T therapy focus.
  • Collaboration with Multiply Labs may face technological challenges, delaying production timelines.
  • Financial strain from new R&D facility could affect operational focus if advancements lag.

What makes Legend Biotech unique

  • Legend Biotech focuses on novel cell therapies for oncology, including CAR-T and NK cells.
  • The company is technology agnostic, exploring multiple platforms for effective cancer treatments.
  • Legend Biotech's CARVYKTI® is the first BCMA-targeted CAR-T therapy approved for second-line use.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Paid Sick Leave

Paid Holidays

Remote Work Options