Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy. 

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is starting their Summer Internship for the year of 2024! The Bioanalytical Sciences Team is seeking an Intern for a 10 week Internship Program that will run from June 10th, 2024 to August 16th, 2024. We are looking for students or recent grads who are passionate about helping others and building something that matters.

Role Overview

The intern will support the team in their efforts to develop intracellular phosphorflow of SMAD method to evaluate TGF-b signaling pathway in :B2102 CAR drug products.

Key Responsibilities  

• Learn flow cytometry.
• Learn cell culture.
• Understand the workflow in industry.
• Develop Intracellular phosphorflow of SMAD using TGF-Beta stimulated and unstimulated cell line (SUB-T1 cell line) and donor T cells from whole blood.
• Apply this intracellular assay to the DLL3 drug products and further optimize the assay with an extended flow panel including surface markers (CD3, CD4,and CD8).

Requirements

• Experience of working with human blood and trained in handling blood-borne pathogens (Hepatitis B vaccinated is preferred).
• Knowledge of immunology and tumor microenvironment.
• Knowledge of cell culture, cell-based assays, flow cytometry is strongly desired.
• Excellent organization skills, good verbal and written communication skills are required.
• Ability to work independently on routine assignments and to work cooperatively with senior staff providing key assistance on complex assignment.
• Perform flow data analysis using Flowjo software.
• Computer experience must include familiarity with Word, Excel and PowerPoint.

#LI-RT

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.