Full-Time

Enterprise AI Architect

Posted on 9/11/2026

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

10,001+ employees

Pediatric cancer treatment and research nonprofit

No salary listed

Remote in USA + 2 more

More locations: Coppell, TX, USA | Memphis, TN, USA

Hybrid

Hybrid work is available near the Memphis or Coppell offices; remote arrangements may be available elsewhere in the U.S.

Bachelor's

Category
IT Operations
Required Skills
LLM
Kubernetes
OpenShift
Machine Learning
RAG
LangGraph
Observability
LangChain

Get referred to St. Jude Children's Research Hospital

See people who can refer or advise you

Requirements
  • A bachelor's degree in Computer Science, Information Systems, Engineering, or a related field.
  • At least 10 years of experience in enterprise architecture, solution architecture, systems integration, software engineering, or related technology disciplines.
  • Experience designing and implementing artificial intelligence, generative artificial intelligence, machine learning, or intelligent automation solutions.
  • Experience developing architecture standards, reference architectures, and technology governance practices.
  • Strong understanding of cloud platforms, application integration, enterprise security, and modern software architecture patterns.
  • Ability to communicate technical concepts effectively to both technical and non-technical stakeholders.
  • At least 5 years of leadership, team lead, or architecture influence experience.
Responsibilities
  • Define enterprise architecture standards, reference architectures, and implementation patterns for artificial intelligence, agentic artificial intelligence, and artificial-intelligence-enabled solutions.
  • Partner with Enterprise Architecture, Engineering, Data, Security, and business teams to evaluate artificial intelligence use cases, establish success criteria, and provide guidance on architectural tradeoffs, including model selection, agent design patterns, cost considerations, and responsible artificial intelligence practices.
  • Design and maintain reusable architecture patterns for artificial intelligence gateways, Model Context Protocol integrations, agent orchestration, enterprise knowledge access, retrieval architectures, and artificial intelligence platform services.
  • Establish architectural guidance for artificial intelligence security, identity management, authorization, governance, compliance, and policy enforcement.
  • Support adoption of artificial intelligence development lifecycle practices through architecture reviews, standards, reference implementations, and implementation guidance.
  • Define architectural approaches for artificial intelligence evaluation, observability, monitoring, operational readiness, and cost management.
  • Develop reference implementations and proof-of-concept solutions that accelerate delivery and help teams scale artificial intelligence capabilities into production environments.
  • Ensure artificial intelligence and technology solutions align with enterprise architecture standards, strategic technology roadmaps, and long-term operational objectives.
  • Collaborate with stakeholders to gather, analyze, communicate, and validate requirements impacting ALSAC's enterprise technology environment.
Desired Qualifications
  • Enterprise artificial intelligence architecture expertise with Bedrock, Model Context Protocol, artificial intelligence gateways, LangGraph or LangChain, retrieval-augmented generation, and agentic artificial intelligence platforms.
  • Strong architecture and implementation experience across OpenShift or Kubernetes and scalable artificial intelligence infrastructure, including deployment, operations, and lifecycle management of long-running agents.
  • Knowledge of large language models, retrieval-augmented generation, agent frameworks, vector databases, and artificial intelligence observability practices.
  • Experience with responsible artificial intelligence, artificial intelligence governance, security, and compliance frameworks.
  • Experience creating reusable frameworks, accelerators, and architecture guidance for enterprise technology teams.
St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

View

St. Jude runs a nonprofit pediatric treatment and research center focused on childhood cancers, especially leukemia. It provides treatment and covers medical costs, travel, housing, and meals for patients and families, with no bills to families. Care comes from clinical treatment at the hospital while researchers develop therapies and run trials; results are shared openly with doctors worldwide. Its goal is to cure childhood cancer and relieve families’ financial burden by sharing knowledge globally.

Company Size

10,001+

Company Stage

Grant

Total Funding

$54.8M

Headquarters

Memphis, Tennessee

Founded

1962

Get referred to St. Jude Children's Research Hospital

See people who can refer or advise you

Simplify Jobs

Simplify's Take

What believers are saying

  • St. Jude named Charles Roberts CEO on August 18, 2026, preserving internal continuity.
  • September 2026 awareness campaigns and August fundraising milestones keep donor inflows visibly strong.
  • ARC II and new clinical facilities expand capacity through 2029 and beyond.

What critics are saying

  • August 2026 plaintiffs filed age and race-bias claims against St. Jude in Tennessee.
  • CFO Pat Keel left in April 2026, and CEO James Downing exits January 2027.
  • ARC II’s $810 million build and 2028 data-center expansion raise execution strain.

What makes St. Jude Children's Research Hospital unique

  • St. Jude remains the only WHO Collaborating Centre dedicated to pediatric cancer, since June 2026.
  • August 2026 research releases show broad scientific depth: brain tumors, CAR T, leukemia.
  • ALSAC funds care globally, letting St. Jude treat families without bills.

Help us improve and share your feedback! Did you find this helpful?

Benefits

Health Insurance

401(k) Retirement Plan

401(k) Company Match

Unlimited Paid Time Off

Maternity / Paternity Leave

Fertility Treatment Support

Adoption Assistance

Education Assistance

Enterprise Learning and Development

Growth & Insights and Company News

Headcount

6 month growth

-7%

1 year growth

-7%

2 year growth

-7%
Tubefilter
Dec 1st, 2020
YouTube’s Latest Original Is A Charitable ‘Secret Santa’ Exchange With AsapSCIENCE, Molly Burke, More

YouTube’s brand new holiday original is one giant 'Secret Santa' gift exchange -- with myriad charity tie-ins and the involvement of 12 of the platform’s most beloved channels. Premiering today, with all 12 episodes live now, The Great Gift Exchange will see creators partake in a giving chain -- with each installment benefiting a charity of their choosing, all while paying it forward to the next creator on the chain. The series is hosted by gift wrap artist Alton DuLaney, who will educate viewers on the art of gift wrapping while wrapping each charitable donation in a creative manner that’s bespoke to each creator’s personal brand. Participants in The Great Gift Exchange -- who count a combined 78 million subscribers -- include: AsapSCIENCE (Rainbow Railroad), Molly Burke (Mira Foundation), Shalom Blac (St. Jude), Rosanna Pansino (Feeding America), Physics Girl (The Malala Fund), Alex Wassabi (Make-A-Wish Foundation), Kristopher London (The Bail Project), Ambers Closet (Lunch on Me), Jennelle Eliana (Covenant House), Smosh Games (Okra Project), MatPat (No Kid Hungry), and Kurt Hugo Schneider (Bat Conservation). YouTube’s brand new holiday original is one giant 'Secret Santa' gift exchange -- with myriad charity tie-ins and the involvement of 12 of the platform’s most beloved channels.

PYMNTS
Nov 11th, 2020
Blackhawk Network Buys National Gift Card

Global branded payments provider Blackhawk Network has acquired National Gift Card, one of the biggest North American prepaid tech and card companies, according to a press release emailed to PYMNTS.

Tubefilter
Oct 14th, 2020
Digital Creator-Focused Charity Platform Tiltify Raises $6.5 Million

Creator-centric fundraising platform Tiltify, which has been harnessed by the likes of Jacksepticeye, Markiplier, DrLupo, Jordan Fisher, and Emilia Clarke to raise money for a whole host of charities, has just announced a venture funding round of its own totaling $6.5 million.