Principal Scientist

Denali Therapeutics

Denali Therapeutics

201-500 employees

Develops therapies for neurodegenerative diseases


$158000 - $206780


Senior, Expert

San Bruno, CA, USA

  • PhD in pharmacokinetics, pharmacology/toxicology, immunology, biochemistry, engineering, or related field with industry/post-doctoral experience of 7+ years, or BS/MS with 12+ years.
  • Established expertise in large molecule pharmacokinetics, with experience in the biological factors and molecular physicochemical attributes that may impact PK and disposition.
  • Proven track record investigating PK/PD relationships for large molecule therapeutics, including analysis using appropriate software applications (i.e WinNolin, Watson, etc.).
  • Understanding of bioanalytical methods (ligand binding assays, mass spectrometry, or other biodistribution methodologies) to assess protein therapeutics PK and disposition in biological matrices.
  • Excellent critical thinking and scientific skills, and a demonstrated ability to analyze, interpret, and clearly communicate complex results.
  • Ability to work effectively and collaboratively on cross-functional project teams.
  • Excellent oral and written communication and presentation skills.
  • Serve on teams as the PK expert contributing to the optimization and selection of lead candidates.
  • Support efforts to identify key aspects of target biology impacting PK properties and duration of PD response.
  • Perform PK/PD analyses to establish quantitative understanding of exposure-response.
  • Work closely with our bioanalytical scientists, biologics discovery, toxicology, clinical. pharmacology, and regulatory teams to optimize leads, to select candidates for clinical evaluation, and contribute to regulatory filings.
  • Analyze, interpret, summarize, and present PK and disposition data to internal project teams, senior management, and to global health authorities.
  • Prepare study protocols and coordinate execution of nonclinical PK or PK/PD studies to answer translational questions in support of project deliverables and first-in-human dose predictions.
  • Contribute to the design and TK analysis for non-GLP and GLP toxicology studies.
  • Work closely with project teams, line management and CROs to assure high quality and timely delivery of written reports for regulatory submissions.
  • Write, review, and finalize nonclinical PK sections of regulatory (IND/CTA) filings and contribute to clinical protocol development.

Company Stage


Total Funding



South San Francisco, California



Growth & Insights

6 month growth


1 year growth


2 year growth