Full-Time

Associate Director

Finance

Orchard Therapeutics

Orchard Therapeutics

201-500 employees

Autologous gene therapies for rare diseases.

No salary listed

London, UK

Hybrid

Hybrid work arrangement in London.

Bachelor's, Master's, MBA

Category
Finance & Banking (1)
Required Skills
NetSuite
ERP
Forecasting
Excel/Numbers/Sheets

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Requirements
  • The candidate must have 7+ years of progressive experience in finance, accounting, or related roles, including leadership responsibilities across financial reporting and financial planning and analysis.
  • The candidate must have strong technical accounting expertise and experience navigating complex technical accounting issues.
  • The candidate must have demonstrated experience in financial planning, forecasting, and business partnering with senior stakeholders.
  • The candidate must have experience with enterprise resource planning and planning systems, ideally NetSuite and Adaptive Planning, and advanced proficiency in Excel.
  • The candidate must have strong organizational and prioritization skills and the ability to manage multiple deadlines in a fast-paced environment.
  • The candidate must have excellent communication skills and the ability to translate complex financial information for non-financial stakeholders and influence decision-making.
  • The candidate must be able to build relationships and partner effectively with cross-functional teams and senior leadership.
  • The candidate must have a bachelor's degree in finance or accounting.
Responsibilities
  • Maintain a strong financial reporting and control environment.
  • Lead the month-end close process, ensuring the accuracy, timeliness, and completeness of financial results, including performing detailed account analysis, recording journal entries, and preparing and reviewing account reconciliations.
  • Maintain the company's internal control framework to ensure compliance with regulatory requirements and company policies.
  • Provide technical accounting leadership, including resolving complex accounting transactions.
  • Implement new accounting standards, including issuing and updating corporate accounting policies and procedures.
  • Act as a strategic finance business partner by providing monthly results and financial analysis.
  • Support the business with the annual planning cycle and quarterly forecasting activities.
  • Collaborate with the parent company and affiliates by responding to ad hoc questions and requests.
  • Support corporate financial planning, forecasting, and budgeting processes across departments.
  • Manage staff and all aspects of accounts payable and the employee expense reporting process.
Desired Qualifications
  • Industry-specific experience in biotechnology or healthcare is preferred, ideally including experience at a public accounting firm.
  • The candidate should have a master's degree in business administration or finance, or a related field.
  • A Chartered Accountant, Certified Public Accountant, or similar professional designation is strongly preferred.

Orchard Therapeutics develops autologous ex vivo gene therapies to treat rare, life-threatening genetic diseases. Its approach collects a patient’s hematopoietic stem cells, edits a functional gene outside the body, and reinserts the corrected cells to rebuild the blood and immune system. The company differentiates itself by delivering single-dose, patient-specific cures that aim to address the disease at its source, with Libmeldy/Lenmeldy as its approved product and a clinical-stage pipeline for other conditions. Orchard’s goal is to provide safe, one-time therapies for children with severe genetic disorders and to expand a portfolio of approved and investigational gene therapies through its Kyowa Kirin ownership.

Company Size

201-500

Company Stage

IPO

Headquarters

London, United Kingdom

Founded

2015

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Simplify Jobs

Simplify's Take

What believers are saying

  • Kyowa Kirin’s February 3, 2026 £11 million UK investment funds Orchard’s development base.
  • OTL-203 finished enrollment nearly one year early on July 7, 2025, accelerating value inflection.
  • Lenmeldy reimbursement keeps expanding, including Beneluxa access and U.K. NHS availability.

What critics are saying

  • Revenue still hinges on Lenmeldy and Libmeldy; one launch failure cripples Kyowa Kirin’s rare-disease bet.
  • OTL-201 remains unapproved; a proof-of-concept stumble would freeze Orchard’s next-product story.
  • Bluebird, academic transplant centers, and newborn screening programs keep pressuring MLD adoption through 2027.

What makes Orchard Therapeutics unique

  • Libmeldy and Lenmeldy are the first approved ex vivo HSC gene therapies for early-onset MLD.
  • Orchard’s 2026 OTL-201 ILAP designation shows UK regulators still back its HSC platform.
  • OTL-203’s July 7, 2025 registrational trial beat standard allogeneic HSCT head-to-head.

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Benefits

Hybrid Work Options

Growth & Insights and Company News

Headcount

6 month growth

2%

1 year growth

1%

2 year growth

2%
BioPharm International
Apr 8th, 2026
Orchard Therapeutics announces new gene therapy manufacturing facility.

Orchard Therapeutics announces new gene therapy manufacturing facility. A new facility in California will expand Orchard Therapeutic's capacity to develop and deliver lentiviral vector and gene-corrected hematopoetic stem cells. Orchard Therapeutics announced in a Dec. 13, 2018 press release that it signed a long-term lease agreement to build out a gene therapy manufacturing facility in Fremont, CA. The new 150,000-ft[2] facility adds to the Foster City and Menlo Park, CA sites, which oversee the ongoing development and validation of the manufacture of Orchard's ex vivo gene therapy product candidates. Once operational, the new site will provide cGMP manufacturing capacity for both lentiviral vector and cryopreserved cell therapy products, enhancing Orchard's ability to manufacture and deliver gene-corrected hematopoetic stem cells for a range of diseases on a global basis. In addition to this expanded capacity, the company also plans to continue its collaborations with its contract manufacturing partners. "The expansion of our California operations to now include a manufacturing facility is a critical step in advancing Orchard's capabilities to supply products for our ex vivo gene therapy programs," said Stewart Craig, chief manufacturing officer of Orchard Therapeutics, in the press release. "We believe that this new facility, as an early investment in our own manufacturing, will not only drive efficiencies and scalability in terms of lentiviral vector and drug product development, it will also complement the capabilities of our existing vector and drug product manufacturing partners to support the potential launch of our gene therapy clinical product candidates." The build-out of Orchard's new manufacturing facility is expected to begin in 2019, and the company expects to hire more than 100 full-time employees over the next few years to support in-house manufacturing efforts. Stay at the forefront of biopharmaceutical innovation - subscribe to BioPharm International for expert insights on drug development, manufacturing, compliance, and more.

Marcom Globe Italy
Oct 7th, 2024
Orchard Therapeutics and Er-Kim Announce Partnership to Broaden Access to Libmeldy to Eligible Patients in Turkey and Certain Eurasian Countries

Er-Kim will collaborate with Orchard Therapeutics to refer eligible children with early-onset MLD identified in these countries to an established European-based qualified treatment center.

UnLimited Media
Mar 29th, 2024
French indie label body UPFI calls on French government to intervene in potential Warner Music Group takeover of Believe

Believe "embodies a model of success and resistance to the worrying phenomenon of consolidation at work in the sector that has seen the successive acquisition of many significant distributors", it adds, highlighting Sony Music's acquisition of The Orchard and AWAL.

BioSpace
Mar 19th, 2024
Orchard Wins Fda Approval For First Gene Therapy For Rare Pediatric Disease

Pictured: FDA signage at its headquarters in Maryland/iStock, hapabapaThe FDA on Monday approved Orchard Therapeutics’ autologous gene therapy atidarsagene autotemcel, which will now be marketed as Lenmeldy, for the treatment of metachromatic leukodystrophy in pediatric patients.Lenmeldy is the first authorized gene therapy for children with pre-symptomatic late infantile or early juvenile metachromatic leukodystrophy (MLD), according to the FDA’s press release on the approval. Lenmeldy is also the first approved therapy for early juvenile or early symptomatic forms of the disease.Orchard CEO Bobby Gaspar in a statement said that Lenmeldy’s approval “opens up tremendous new possibilities” for children suffering from these early-onset forms of MLD, “who previously had no treatment options beyond supportive and end-of-life care.”The company on Monday did not provide specific launch details for Lenmeldy but promises to do so within the week.MLD is a rare and heritable metabolic disease that affects one in every 100,000 live births. It is characterized by a pathological build-up of sulfatides in the brain, liver, kidneys, spleen and other body parts, which over time can cause organ damage and neurological issues. Those with MLD often suffer from motor, behavioral and cognitive problems, as well as seizures. Patients also slowly lose the ability to move, talk, swallow and eat.Children with MLD often degenerate to a vegetative state and require round-the-clock care. Most patients die within five years of disease onset.MLD is caused by a mutation in the arylsulfatase-A (ARSA) gene, which under healthy circumstances produces an enzyme that breaks down sulfatides

Ochre Digi Media Pvt Ltd.
Jan 26th, 2024
Orchard Therapeutics Enters Agreement with Beneluxa Consortium to Facilitate Reimbursed Access to Libmeldy

Orchard Therapeutics enters agreement with Beneluxa consortium to facilitate reimbursed access to Libmeldy.