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Full-Time

Senior Scientist

Chemistry

Confirmed live in the last 24 hours

Sarepta

Sarepta

Compensation Overview

$120k - $150kAnnually

Senior, Expert

Cambridge, MA, USA

Requires on-site work at Sarepta’s facilities in the United States.

Category
Computational Biology
Genomics
Public Health
Biology & Biotech
Requirements
  • PhD in organic chemistry, biochemistry, or related fields with 4+ years of relevant post-doctoral or industry experience; or M.S. with 8+ years of experience.
  • Strong experience in organic chemistry and multi-step organic synthesis is a must.
  • Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.
  • Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.
  • Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.
  • Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.
  • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.
Responsibilities
  • Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.
  • Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships.
  • Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data.
  • Serves as an in-house oligonucleotide and delivery chemistry expert.
  • Drive the writing of technical reports to support patent applications and manuscript preparations.
  • Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs.
  • Organize workstreams and complete individual and team objectives to maintain project timelines.
  • Supervise and mentor junior staff.

Company Stage

N/A

Total Funding

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Headquarters

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