Full-Time
Detects low-abundance biomarkers with qPCR assays
$160k/yr
Woburn, MA, USA
In Person
Approximately 30% travel to customer sites, primarily on the East Coast, with occasional international travel; otherwise onsite at the Woburn headquarters.
PhD
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Spear Bio develops highly sensitive biomarker detection technology that can identify disease indicators even when present at very low levels, including single-digit protein counts. It uses a proprietary 2-factor authentication detection method with sub-microliter samples, enabling minimally invasive collection and testing on non-proprietary qPCR instruments for easy automation. The platform is designed to integrate into existing lab workflows, offering open-system compatibility and scalable testing for large groups. The goal is to provide labs and healthcare providers with precise, scalable biomarker detection to support broad screening and diagnostics.
Company Size
51-200
Company Stage
Series A
Total Funding
$52.3M
Headquarters
Woburn, Massachusetts
Founded
2021
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Spear Bio's SPEAR UltraDetect(TM) BD-pTau 217 Assay named a 2026 R&D 100 Award winner. Published on: August 11, 2026 Prestigious R&D 100 Award recognizes Spear Bio's innovation in ultra-sensitive measurement of brain-derived pTau 217 in plasma WOBURN, Mass.-(BUSINESS WIRE)- Spear Bio, a biotechnology company pioneering wash-free ultrasensitive immunoassay technology, today announced that its SPEAR UltraDetect(TM) BD-pTau 217 Assay has received a 2026 R&D 100 Award. Presented annually by R&D World, the awards recognize 100 of the year's most technologically significant new products and advancements from organizations around the world. For more than six decades, the R&D 100 Awards have recognized excellence in research and development across industry, academia, and government. The 2026 winners were selected from 149 finalists by a judging panel comprising more than 50 industry professionals from around the world. Brain-derived pTau 217 represents a central nervous system-specific subset of circulating pTau 217 and is present at substantially lower concentrations than total plasma pTau 217, making reliable measurement, particularly in healthy individuals and early-stage populations, a significant analytical challenge. The SPEAR UltraDetect(TM) BD-pTau 217 Assay addresses this challenge with a functional lower limit of quantification of 25 fg/mL while requiring just 1 μL of diluted plasma. Across the evaluated healthy-control and Alzheimer's disease plasma samples, the assay achieved 100% quantifiability. In PET-confirmed research cohorts, BD-pTau 217 measurements demonstrated strong differentiation between amyloid-negative and amyloid-positive groups, illustrating how greater analytical sensitivity can translate into more informative biological insight. "Brain-derived pTau 217 has historically been difficult to measure reliably because of the exceptionally low concentrations present in plasma," said Feng Xuan, PhD, Founder and CEO of Spear Bio. "This award recognizes the technical ingenuity of our team in developing the most sensitive BD-pTau 217 assay with the lowest sample-volume requirement. By overcoming a fundamental measurement challenge, we are giving researchers access to brain-derived tau biology across a broader biological range and enabling new opportunities for early-stage, longitudinal, and therapeutic research in Alzheimer's disease." "Breakthrough analytical performance alone is not enough, it has to be translated into a robust and reproducible product that researchers can use with confidence," said Zidong Wang, COO of Spear Bio. "Bringing this assay to market required close collaboration across assay development, technology transfer, operations, quality, and manufacturing. This award recognizes both the scientific innovation behind BD-pTau 217, and the disciplined cross-functional execution required to translate that innovation into a high-performance research tool." The assay is powered by Successive Proximity Extension Amplification Reaction (SPEAR) technology. Its two-factor authentication mechanism and homogeneous, wash-free format enable sensitive and precise protein measurement without solid-surface capture or washing, with results read using standard qPCR instrumentation. To learn more about the assay and review the supporting data, visit the SPEAR UltraDetect(TM) BD-pTau 217 Assay Kit product page: https://spear.bio/products/bd-ptau-217/ About Spear Bio Spear Bio, founded in 2021 and headquartered in Woburn, Massachusetts, is a biotechnology company pioneering wash-free ultrasensitive immunoassay technology. Its SPEAR UltraDetect(TM) assay platform delivers attomolar sensitivity from 1 μL of diluted sample and superior specificity of a homogeneous, wash-free format with readout on standard qPCR instruments. Built on an ultra-performance approach that integrates sensitivity, specificity, precision, and assay robustness, Spear Bio enables researchers and clinicians to reveal true biology with confidence. By combining exceptional analytical performance with simplified workflows and widely available laboratory infrastructure, the company is expanding access to high-quality protein biomarker insights and accelerating the translation of discoveries into clinical applications. Media Contact Courtney Shirley [email protected]
Spear Bio to unveil novel Alzheimer's disease immunoassays and fully automated instrument platform at AAIC 2026. July 7, 2026 san francisco biotechnology network news news, syndication comments off on spear Bio to unveil novel Alzheimer's disease immunoassays and fully automated instrument platform at AAIC 2026. WOBURN, Mass.-(BUSINESS WIRE)-Spear Bio, an innovator in ultrasensitive protein biomarker detection, today announced plans to unveil new SPEAR immunoassay and instrument innovations at the Alzheimer's Association International Conference(R) 2026, taking place July 12-15 in London, UK. The launches include the first commercially available singleplex immunoassay for eMTBR-Tau, a novel epTau 217 assay for measuring pTau 217 across venous and capillary blood, and an instrument platform to fully aut Click here to view original post Discover more Pharmaceuticals & Biotech
Spear Bio will unveil new Alzheimer's disease immunoassays and a fully automated instrument platform at the Alzheimer's Association International Conference 2026 in London this month. The launches include the first commercially available singleplex immunoassay for eMTBR-Tau and a novel epTau 217 assay for measuring pTau 217 across venous and capillary blood. Both assays use Spear Bio's proprietary Successive Proximity Extension Amplification Reaction technology, which requires just 1 µL of diluted plasma. The new instrument platform will automate SPEAR workflows from sample to qPCR-ready plate, reducing manual handling and supporting more consistent execution of biomarker assays. The Massachusetts-based biotechnology company, founded in 2021, aims to provide researchers with tools to measure complex Alzheimer's disease biology and support neurodegenerative disease research.
Meet Spear Bio at the 5th ALS Drug Development Summit. Event Date: June 2, 2026 Spear Bio is attending the 5th ALS Drug Development Summit, taking place June 2-4, 2026 in Boston, MA, where leaders across biotech, pharma, academia, clinical development, regulatory science, and patient advocacy will come together to accelerate the next generation of ALS and FTD therapeutics. As ALS and FTD programs increasingly rely on more predictive translational strategies, patient stratification, longitudinal monitoring, and blood-based biomarker insights, Spear Bio is helping researchers detect low-abundance protein biomarkers with exceptional sensitivity from ultra-small sample volumes. Featured presentation. SPEAR Immunoassays for Neurodegenerative Biomarker Detection Wednesday, June 3, 2026 | 9:00 am ET * A novel immunoassay platform enabling ultra-sensitive detection of low-abundance neurological biomarkers in blood * Advancing translational and clinical research through high sensitivity, specificity, and precision across challenging neurodegenerative biomarkers * Expanding beyond established biomarkers with custom assay development to support biomarker-driven therapeutic development Feng Xuan, PhD Founder & CEO, Spear Bio Let's talk biomarkers in Boston. Whether you are building an ALS translational strategy, evaluating blood-based biomarkers, developing assays for low-abundance targets, or looking for more sensitive tools to support neurodegenerative research, its team would welcome the opportunity to connect.
Spear Bio launches ultrasensitive assays to advance Parkinson's disease biomarker testing. Published: 21 May 2026 In March 2026, Spear Bio introduced three new ultrasensitive immunoassays that are specifically designed to advance blood-based biomarker testing for Alzheimer's disease and Parkinson's disease, and debuted the products at the International Conference on Alzheimer's & Parkinson's Diseases in Copenhagen. The new SPEAR UltraDetect immunoassays target brain-derived phosphorylated tau 217 (BD-pTau 217), α-synuclein (α-syn), and phospho-Ser129-α-synuclein (pS129-α-syn) protein biomarkers associated with neurodegenerative proteinopathies. The product launches align with the company's establishment of direct-to-consumer operations in North America and Europe, based in Woburn, Massachusetts. BD-pTau 217: detecting Alzheimer's at the preclinical stage. The SPEAR UltraDetect BD-pTau 217 Assay was first released to early adopters last month and is described by the company as the only brain-derived pTau 217 test to achieve 100% quantifiability in both healthy and diseased plasma samples. Operating in a homogeneous, wash-free format, the assay requires just 1 μL of diluted plasma, achieves a functional lower limit of quantification of 25 fg/mL, and an average intra-plate coefficient of variation of 5.7%. According to the company, these performance characteristics enable investigators to detect Alzheimer's disease-related tau changes at the preclinical stage while conserving sample volume for longitudinal studies, a critical consideration for researchers managing limited biobanked specimens. "Our goal is to place the most sensitive protein biomarker tools in the hands of scientists tackling complex neurodegenerative diseases," stated Feng Xuan, founder and chief executive officer of Spear Bio. "By expanding our assay portfolio and transitioning to direct customer engagement, we are empowering researchers to generate higher-quality data with greater efficiency, accelerating the path from discovery to clinical impact." According to Precedence Research, the parkinsons disease biomarkers market size was USD 1.35 billion in 2025 and is projected to increase from USD 1.54 billion in 2026 to approximately USD 4.88 billion by 2035, expanding at a CAGR of 13.80% from 2026 to 2035, driven by the growing need for early diagnosis, rising shift to blood-based diagnostics, increasing global cases of Parkinson's diseases, rapid advancements in alpha-synuclein assays, and increasing investments in clinical trials for disease-modifying therapies.