AA-Alpha Bio helps drug developers accelerate discovery of biologics, which are therapeutic proteins. Its platform rapidly and quantitatively measures millions of protein–protein binding affinities, enabling simultaneous characterization of how a library of proteins binds to many targets. This allows screening antagonists across full interaction networks and identifying biologics with specificity to multiple targets. Revenue comes from service contracts, licenses, and collaborative partnerships with pharmaceutical and biotech firms. The company differentiates itself by providing a scalable, quantitative binding-measurement platform that can profile binding across large target networks, supporting fast, targeted discovery. Its goal is to advance drug discovery by delivering high-precision binding data to enable the design of specific, effective biologics.
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Company Size
11-50
Company Stage
Grant
Total Funding
$63.2M
Headquarters
Seattle, WA
Founded
2017
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Total Funding
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Startup Spotlight: ScopeSys gives drugmakers a closer look inside genomic medicines. Medical researchers need cutting-edge tools to create new treatments, and Vancouver, BC startup ScopeSys wants to provide them. Founded in 2017 and tracing its roots to research from University of British Columbia biophysicist Sabrina Leslie, ScopeSys uses physics to make testing new medicines quicker and cheaper. The 7-person company, which recently closed a $1.1 million seed funding round, is developing tools that let drugmakers observe individual RNA and DNA molecules, giving researchers a more precise way to design new forms of medicines. We caught up with ScopeSys CEO Padma Kodukula - a longtime biotech leader who most recently served as chief business officer at A-Alpha Bio - for this installment of GeekWire's Startup Spotlight. In 50 words or less, give us your startup's elevator pitch. ScopeSys is developing next-generation analytical instruments that reveal the size, payload, structure, and dynamic behavior of individual nanoparticles and biomolecules. Our proprietary Convex Lens-induced Confinement (CLiC) technology helps pharmaceutical and biotechnology companies design better genomic medicines, accelerate formulation development, improve scale-up, and strengthen manufacturing control. What problem are you obsessed with solving? I am obsessed with improving how genomic medicines are characterized. These therapies are complex and highly heterogeneous, yet many existing analytical methods report only population averages. We want to give scientists particle-by-particle and molecule-by-molecule insight so they can better understand what they are making, why it works, and how to manufacture it consistently. What surprised you after talking to customers? I was surprised by how actively customers seek technologies that can give them a meaningful competitive advantage. Pharmaceutical and biotechnology teams are highly sophisticated, but they still face major analytical gaps. They are willing to explore cutting-edge tools when technology can answer important questions that existing methods cannot and provide actionable data. How has AI changed the way you build your company? AI has multiplied our efficiency across nearly every part of the company. We use it to accelerate scientific research, analyze market and competitive information, refine product positioning, develop customer materials, support sales outreach, and improve internal decision-making. It allows a small team to operate with the speed and breadth of a much larger organization. What is one thing people misunderstand about your startup? Some people assume we are still an academic research project because our technology originated at the University of British Columbia. In reality, ScopeSys is a commercial, revenue-generating company. We are translating years of scientific innovation into robust instruments, consumables, AI datasets, and analytical services designed for pharmaceutical, biotechnology, and research laboratories. What is the toughest decision you have made in the past year? The toughest decision has been balancing near-term service revenue with the long-term investment required to commercialize our instrument platform. Services generate important customer validation and cash flow, but building a scalable product company requires disciplined choices about hiring, capital allocation, product development, and which opportunities to prioritize. What is the one piece of advice you give to other entrepreneurs? There will be many hurdles throughout the entrepreneurial journey, and some will feel overwhelming in the moment. Keep moving forward. Most challenges eventually pass, especially when you remain focused, adaptable, and persistent. Perseverance does not mean ignoring problems; it means continuing to solve them one at a time. We will know our company has made it when... Our technology and instruments are routinely used across pharmaceutical, biotechnology, and academic laboratories as a standard tool for developing genomic medicines - helping scientists build better formulations, accelerate process scale-up, understand product heterogeneity, and support manufacturing and quality control.
Exclusive: A David Baker spinout launches AI antibody data consortium with GSK, Boltz and others. July 28, 2026 WOBN news, syndication comments off on exclusive: A David Baker spinout launches AI antibody data consortium with GSK, Boltz and others. A-Alpha Bio, a startup spun out of David Baker's lab, led by David Younger, has launched a first-of-its-kind AI antibody data consortium with GSK, Boltz Bio, Dyno Therapeutics, and Cradle. The initiative aims to accelerate AI-driven antibody discovery by generating and sharing large-scale experimental data among members.
A-Alpha Bio has launched Atlas, a web platform designed to provide researchers with large-scale antibody-antigen affinity and structural data for AI-driven protein engineering. The platform addresses a critical data shortage in AI-enabled drug discovery, offering access to 450 million affinity measurements and over 7,000 lab-validated antibody-antigen pseudo-structures. Atlas enables researchers to either license existing datasets organised into application-specific "Data Blocks" or generate custom data using A-Alpha Bio's AlphaSeq platform. The company also introduced the Atlas Consortium, which aggregates and distributes datasets quarterly to subscribers. CEO David Younger noted that whilst the Protein Data Bank contains fewer than 10,000 antibody-antigen structures, generalizable AI models require significantly more data. The Seattle-based biotechnology company, founded in 2017, aims to establish Atlas as the experimental data layer for AI-native protein engineering.
Overland AI raises $100M to meet military demand. GeekWire. * Keep track of the latest startup funding news with our handy list. Tech Moves: Qualtrics taps former Oracle exec Jason Maynard as its CEO; Microsoft 's accessibility leader Jenny Lay-Flurrie takes a new role; and more key personnel changes. * Bellevue telecom giant T-Mobile is cutting 393 jobs in Washington state. * Amazon is laying off nearly 2,200 employees, mostly in Seattle and Bellevue - and software engineers account for the largest share of the cuts. * We're keeping a list of recent workforce reductions here. Who will buy the Seattle Seahawks? Deep passes might be a focus on Super Bowl Sunday, but deep pockets are going to be needed when the team eventually goes up for sale. We put together a list of tech execs and other billionaires who could step up for the 12s. * In a new annual letter, Gates Foundation CEO Mark Suzman lays out an ambitious roadmap for the nonprofit's next 20 years. (Gates Foundation) * Amazon grew the number of items delivered in less than a day by 70% in 2025. (Amazon News) * Melinda French Gates said she feels "unbelievable sadness" when she reads the latest claims against her ex-husband Bill Gates in the Epstein files. (NPR via YouTube) * A proposed statewide payroll tax on big businesses in Washington has little political support and is unlikely to advance this session, the senate majority leader says. (Washington State Standard) * Jeff Bezos said it was a "huge honor" to host Defense Secretary Pete Hegseth at Blue Origin's facilities in Florida. (X) * The original Nintendo Switch is Nintendo's best-selling hardware of all time. (IGN) * Seattle startup RevealDX announced FDA clearance for its lung nodule risk assessment software. (RevealDX) * Seattle biotech startup A-Alpha Bio is partnering with Novo Nordisk to boost drug discovery using AI. (A-Alpha Bio) SPONSOR MESSAGE: Seattle Kraken Single-Game Tickets. There's nothing like a night of Kraken hockey in The Deep. From puck drop to the final horn, feel every hit, goal, and crowd surge live at Climate Pledge Arena. Single-game tickets are available now!
A-Alpha Bio appoints Troy Lionberger as new Chief Business Officer to drive next phase of growth.
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Industries
Company Size
11-50
Company Stage
Grant
Total Funding
$63.2M
Headquarters
Seattle, WA
Founded
2017
Find jobs on Simplify and start your career today
Don't see your dream role? Check out thousands of other roles on Simplify.Browse all jobs