Alpaca VC provides early-stage funding and hands-on support for startups in real estate, fintech, commerce, supply chain, and vertical SaaS. Their approach combines investing with deep, research-driven field studies to understand markets and opportunities, drawing on the founders' own experience as former operators. How it works: they assess and back promising teams, then use practical, field-based insights to help portfolio companies navigate challenges and scale. How they differ: the team consists of former founders and operators who bring real-world experience, and they rely on a rigorous, field-study process to deepen sector expertise across a focused set of industries. Their goal is to help shape a future where everyday life is more seamless, efficient, and accessible by backing the next wave of impactful startups.
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Industries
Company Size
11-50
Company Stage
N/A
Total Funding
$1.2B
Headquarters
New York City, New York
Founded
2012
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Total Funding
$1.2B
Above
Industry Average
Funded Over
0 Rounds
Autopoiesis Sciences, a San Francisco startup building AI tools for scientific research, has raised $11 million in seed funding led by Threshold Ventures. Informed Ventures, Alpaca VC, VitalStage Ventures, Correlation Ventures, and Darkmode Ventures also participated in the round announced on 30 September. The capital will fund development of Aristotle, an AI system designed to assist researchers with literature reviews, hypothesis generation, and experimental design. Threshold claims the tool reaches thousands of researchers at organisations including Pfizer, the FDA, Harvard, GlaxoSmithKline, Merck, and MIT. The company's underlying technology uses what it calls Metacognitive Steering to adjust how AI models reason through complex investigations. CEO Joseph Reth leads the effort alongside co-founders Dr Eike Gerhardt and Dr Lawrence Callahan.
Mainstay, a San Francisco-based provider of an intelligent system of record for residential real estate, has raised over $18 million in funding. Backers included Parker89, Stackpoint, Alpaca VC, FJ Labs, Khosla Ventures, Era Ventures, and Clocktower Technology Ventures. The company will use the funds to expand operations and development efforts. Led by chief executive officer Dod Fraser, Mainstay provides an agentic platform connecting data, decisions, and execution across the residential asset lifecycle. The solution combines proprietary and external data sources into a single record for every property, using agentic automation to handle workflows across transaction execution, property taxes, HOA management, and payments.
Calgary-based Ultimarii has raised $13 million in combined equity and debt financing. BDC Capital's Industrial Innovation Venture Fund led the round, with participation from Mistral Venture Partners, Staircase Ventures and Alpaca VC. The National Research Council of Canada's Industrial Research Assistance Program is also providing funding. The startup develops AI tools that help regulatory agencies, law firms and companies in power, mining and energy industries manage regulatory and permitting applications. The system uses datasets from past government processes and human expertise. Doug Schweitzer, Alberta's former justice and innovation minister, founded Ultimarii in January 2024 with Josh Malate. The company plans to expand internationally, starting with US datasets.
Applied Atomics, a developer of full-stack nuclear power plants, has raised $8.3 million in an oversubscribed seed round. The Los Angeles-based company is designing 100MW to 1GW nuclear power plants co-located with large infrastructure campuses, using light-water reactor architecture. The startup plans to own and operate its plants, delivering electricity under long-term power purchase agreements. It's working with early customers to secure locations for 10GW of planned capacity. The funding will support testing and integration, supply chain development, and engineering integration. Applied Atomics has completed initial systems validation milestones on its SimBox digital twin platform, testing plant control logic and safety responses with supply chain components. The round was co-led by Transition, with participation from Alpaca VC. The company aims to address nuclear deployment challenges through integrated delivery rather than fragmented project models.
Calgary-based AgTech startup Brilliant Harvest has raised $4 million in seed funding to scale its AI-driven customer experience platform for the heavy equipment industry. The round was led by returning investors Builders VC and AltaML, with participation from FTW Ventures, Alpaca VC, Automotive Ventures, SVG Ventures and NYA Ventures. The platform ingests technical manuals, work orders and conversational data to provide fast answers for service, parts and aftermarket teams. Brilliant Harvest now supports dealerships representing over 50 per cent of CNH Industrial's larger dealer stores, with customers including Rocky Mountain Equipment and Titan Machinery. The funding will accelerate platform development and market expansion. The company plans to enter the construction industry in mid-2026 and expand into after-sales processes.
Find jobs on Simplify and start your career today
Industries
Company Size
11-50
Company Stage
N/A
Total Funding
$1.2B
Headquarters
New York City, New York
Founded
2012
Find jobs on Simplify and start your career today