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Altis Labs

AI endpoint platform for oncology trials

Overview

Altis Labs provides AI-powered endpoints for oncology trials, helping sponsors read imaging with its IPRO model trained on a multimodal, longitudinal dataset to generate survival predictions from routine radiology scans and detect treatment effects earlier across Phase 1–4 studies. IPRO analyzes radiology images along with longitudinal imaging, molecular, clinical and outcomes data to output survival predictions and early signals, enabling sponsors to see benefits sooner than traditional endpoints. It differentiates itself by using a large multimodal dataset and a model that directly predicts survival from standard imaging, demonstrated to reveal treatment effects earlier than standard endpoints in independent analyses. The goal is to establish AI-derived clinical endpoints as a standard in oncology trials, expand IPRO to more cancer types, and scale deployments with global biopharma partners.

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About Altis Labs

Simplify's Rating
Why Altis Labs is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & AnalyticsAI & Machine LearningBiotechnologyHealthcare

Company Size

11-50

Company Stage

Series A

Total Funding

$31M

Headquarters

Toronto, Canada

Founded

2019

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What believers are saying

  • OrbiMed and Qiming led Altis' US$25 million Series A on September 17, 2026.
  • Altis says top-20 biopharma users already rely on IPRO across phase 1-4 studies.
  • Digital twins and additional cancer-type expansion could widen adoption with AstraZeneca, Bayer, and J&J.

What critics are saying

  • MARIPOSA was post-hoc; regulators can reject retrospective endpoints without prospective validation by 2027.
  • Twenty-four employees cannot support global biopharma deployments, FDA engagement, and model expansion simultaneously.
  • J&J and other pharma can internalize imaging analytics, compressing Altis' pricing power.

What makes Altis Labs unique

  • Altis Labs turned MARIPOSA, presented September 13, 2026, into survival-linked AI endpoint evidence.
  • Its IPRO model spans 500,000 patient-years across imaging, molecular, clinical, and outcomes data.
  • Toronto-based access to centralized cancer imaging data gives Altis a durable dataset advantage.

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Funding

Total Funding

$31M

Above

Industry Average

Funded Over

2 Rounds

Series A funding typically happens when a startup has a product and some customers, and now needs funding to scale. This money is usually used to grow the team, expand marketing, and improve the product. Venture capital firms are frequently the main investors here.
Series A Funding Comparison
Above Average

Industry standards

$15M
$8.2M
$15M
$25M
$30M

Benefits

  • Health Insurance
  • Vision Insurance
  • Dental Insurance
  • Paid Vacation
  • Company Equity

Company News

Pharmacally
Sep 18th, 2026
Altis Labs Raises $25M to advance AI Endpoints in oncology.

Altis Labs Raises $25M to advance AI Endpoints in oncology. Altis Labs has raised US$25 million in Series A financing to expand its AI-based oncology endpoints, which use routinely collected medical imaging to generate earlier predictions of long-term clinical outcomes. AI models link imaging with survival outcomes. Oncology trials commonly use measures such as objective response rate (ORR) and progression-free survival (PFS) to assess whether an investigational therapy is working. These endpoints can provide earlier signals than overall survival, but their ability to predict long-term clinical benefit varies across therapies and tumor types. Altis built its platform around AI models trained on longitudinal datasets that connect radiology images with patient outcomes. Its flagship model, IPRO, analyzes routinely acquired radiology scans and generates survival predictions. The company's AI endpoint, IPRO Response Rate, provides an earlier measure of treatment effect than conventional imaging-based response assessments. MARIPOSA analysis provides Phase 3 evidence for AI endpoint. Evidence presented at the 2026 World Conference on Lung Cancer came from an independent post-hoc analysis of Johnson & Johnson's Phase 3 MARIPOSA trial. In the analysis, IPRO Response Rate detected a statistically significant treatment effect 11 months before the trial's primary PFS readout and 26 months before the final overall survival readout. By comparison, conventional ORR did not predict the significant survival benefit observed in the trial. The findings indicate that AI-derived imaging endpoints may provide earlier information about whether a treatment is translating into meaningful clinical benefit. However, the MARIPOSA analysis was post-hoc, making broader prospective validation across cancer types, trials and treatment settings important for wider adoption. Investors back expansion of ai-based clinical endpoints. Felix Baldauf-Lenschen, founder and CEO of Altis Labs, said faster and more accurate assessment of treatment benefit could accelerate clinical development and improve decision-making during trials. Tal Zaks, partner at OrbiMed and a former oncology drug developer, highlighted the importance of early efficacy signals that reliably predict patient outcomes. He said Altis has built a longitudinal oncology dataset linking imaging with clinical outcomes and translated it into an AI-derived outcome measure supported by Phase 3 data. Qiming Venture Partners USA managing partner Anna French said earlier efficacy measurement could address some of the costs, timelines and late-stage failure risks associated with oncology drug development. $25 Million round to Fund platform expansion. The Series A was co-led by OrbiMed and Qiming Venture Partners USA, with participation from Innovation Endeavors, Benchstrength, Fusion Fund, the Cancer Breakthrough Fund and other investors. Altis will use the financing to expand its AI models across additional cancer types, increase commercial deployment with global biopharmaceutical partners and further develop AI-derived endpoints for oncology clinical trials. The financing comes as drug developers continue to rely heavily on imaging-based measures for early efficacy decisions, despite limitations in predicting long-term patient outcomes. Next Phase: broader oncology validation. Altis plans to extend its AI models into additional cancer types and expand deployment through partnerships with global biopharmaceutical companies. Further prospective validation and regulatory engagement will be important to establish how AI-derived imaging endpoints can complement or potentially supplement conventional measures in oncology trials. Their broader use could provide drug developers with earlier evidence to inform trial design, efficacy assessment and development decisions. Reference. Altis Labs Raises US$25 Million Series A Co-Led by OrbiMed and Qiming Venture Partners USA to Accelerate Clinical Development with AI Endpoints, Altis Labs, 17 September 2026 About the Writer Khushi Patel is a Pharm.D (Linkedin) professional with a strong foundation in clinical pharmacy, patient-centered care, regulatory affairs, and pharmacovigilance, with published work on Brugada syndrome. Her interests include regulatory affairs, pharmacovigilance, guideline integration, multimodal therapy, pharmacogenomics, and antibiogram utilization, with a focus on evidence-based clinical decision-making and medication safety. As a Pharmacally healthcare writer, she translates clinical and scientific evidence into clear, accurate, and clinically relevant healthcare content, while continuously developing her expertise in evolving pharmacy practice.

Lumira Ventures
Sep 17th, 2026
Altis Labs AI imaging endpoint predicts Overall Survival benefit in Phase 3 Lung Cancer trial.

Altis Labs AI imaging endpoint predicts Overall Survival benefit in Phase 3 Lung Cancer trial. IPRO Response Rate detected treatment effects missed by ORR, eleven months before primary PFS readout and 26 months before final OS readout in a post hoc analysis. TORONTO, CANADA - September 17, 2026 - Altis Labs, Inc. ("Altis"), the AI endpoint company accelerating clinical trials, today announced findings from an independent post-hoc analysis evaluating its AI-powered imaging endpoint, IPRO, in the MARIPOSA Phase 3 trial.[1] The findings, which were presented at the World Conference on Lung Cancer (WCLC) 2026 in Seoul, Republic of Korea, show that Altis' IPRO Response Rate detected an early, notable treatment effect, while RECIST-based objective response rate (ORR) failed to anticipate the investigational treatment's 12+ month median overall survival (OS) benefit. "This readout proves that AI can anticipate meaningful clinical benefit that traditional imaging endpoints like ORR may fail to detect." IPRO Response Rate provides early efficacy signal in EGFR-mutated NSCLC In a post-hoc analysis performed by the trial sponsor, IPRO demonstrated its value as an early endpoint in the trial, which compared treatments in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC). The IPRO AI model automatically analyzed approximately 10,000 radiology scans, generating prognostic outcome measures for each patient at baseline and on-treatment assessments. IPRO Response was defined as a >=50% improvement in the IPRO-α score relative to baseline, and the treatment effect was estimated as the IPRO Response Rate ratio for the investigational treatment versus control arm treatment at landmark early imaging assessments. Key findings include: * IPRO Response Rate favored the investigational treatment beginning at Week 16 (IPRO Response Rate Ratio, 1.33; 95% CI, 1.03-1.71) and throughout subsequent time points, while ORR failed to anticipate the significant OS benefit throughout. * When evaluating pooled, patient-level IPRO trajectories over time, IPRO deterioration was consistently associated with OS detriment, while IPRO improvement was consistently associated with OS benefit. * IPRO scores for the entire trial were generated automatically from routinely acquired CT imaging, providing an objective, reproducible measure of efficacy. "This readout proves that AI can anticipate meaningful clinical benefit that traditional imaging endpoints like ORR may fail to detect," said Felix Baldauf-Lenschen, Founder and CEO of Altis Labs. "We're focused on supporting our biopharma partners and ultimately patients by bringing this level of precision into clinical trials so that efficacy can be detected earlier." The results were presented on September 13th, 2026, at WCLC, Abstract/Poster: P1.046: IPRO-a Response Rate as a Potential Early Endpoint for Overall Survival in MARIPOSA, a Phase 3 Trial in EGFR-Mutated NSCLC. Abstract can be viewed at: https://cattendee.abstractsonline.com/meeting/21487/Presentation/3918 About IPRO IPRO is a fully automated AI system that predicts patient survival directly from the CT scans already acquired in clinical trials. Rather than automating RECIST, IPRO goes beyond measuring target lesion size by analyzing the entire three-dimensional scan to quantify thousands of prognostic imaging biomarkers spanning tumor burden, body composition, and organ health that contribute to multifactorial survival outcomes. At the patient-level, improvements in IPRO (i.e. IPRO Response) are associated with survival benefit, while IPRO deterioration is associated with survival detriment. Clinical trial sponsors use IPRO Response Rate as a novel, survival-linked endpoint to detect early efficacy signals and navigate go/no-go decisions with greater confidence. About Non-Small Cell Lung Cancer (NSCLC) NSCLC accounts for up to 85% of all lung cancer cases worldwide and is the leading cause of cancer death. Epidermal growth factor receptor (EGFR) alterations represent one of the most common driver mutations, found in 10% to 15% of Western patients and up to 40% to 50% of Asian patients with adenocarcinoma histology. Despite advances in targeted therapies, the five-year survival rate for patients with advanced EGFR-mutated NSCLC treated with standard-of-care remains under 20%. About Altis Labs Altis Labs is the AI endpoint company accelerating clinical trials. Altis was founded on the premise that AI's greatest potential lies in generating better evidence, faster. In close partnership with leading cancer centers, Altis has trained a prognostic AI model, IPRO, on the industry's largest multimodal oncology database comprising longitudinal imaging, molecular, clinical, and outcomes data spanning over 500,000 patient years. Top 20 biopharma companies use IPRO to more confidently analyze data from phase 1-4 clinical trials so that they can bring the most effective novel treatments to patients sooner.

Axios
Sep 17th, 2026
Altis Labs raises $25M Series A to speed clinical trials with AI

Altis Labs, an AI software company for drug development, has raised $25 million in Series A funding, CEO Felix Baldauf-Lenschen announced. The company focuses on clinical trial endpoints. AI technology has demonstrated greater advancement in identifying drug candidates than in validating their effectiveness in patients. This creates opportunities for tools that could accelerate clinical development processes. The funding round highlights growing investor interest in AI applications that address later stages of drug development, particularly in streamlining clinical trials.

HealthTech HotSpot
Feb 12th, 2026
INOVAIT Announces Recipients of the 2025/26 INOVAIT Awards, Canadian Health Innovation Ecosystem Awards

INOVAIT announces recipients of the 2025/26 INOVAIT Awards, Canadian health innovation ecosystem Awards. OTTAWA, Ontario - (BUSINESS WIRE) - INOVAIT, Canada's image-guided therapy and artificial intelligence network, presented the 2025/26 INOVAIT Awards at its annual meeting in Ottawa yesterday (February 10, 2026). The INOVAIT Awards recognize industry and academic members of the INOVAIT Network who are developing breakthrough innovations in healthcare and spearheading economic development for Canada. "Through the INOVAIT Awards, we are spotlighting those who are not only advancing breakthrough medical technologies, but also strengthening Canada's health innovation ecosystem," said Kullervo Hynynen, Co-Executive Director of INOVAIT. "The 2025/26 award recipients exemplify the leadership, rigour, and real-world impact that define Canadian medtech." The 2025/26 INOVAIT Awards were granted to the following recipients: Altis Labs received the 2025/26 Maple Leaf Award. The Maple Leaf Award recognizes an industry member who has strengthened working relationships and partnerships with other companies and institutions across Canada. Altis Labs has three INOVAIT R&D projects that have established research collaborations with BC Cancer, Alberta Health Services, Hamilton Health Sciences, Sunnybrook Research Institute, Trillium Health Partners, the University Health Network, and the University of Calgary. Altis brings together Canada's unique AI talent and clinical research excellence to develop prognostic imaging AI models that accelerate drug development. "INOVAIT's support has been vital in bridging the gap between AI research and commercialization," says Duoaud Shah, Head of Clinical Partnerships at Altis Labs. "Together with our pan-Canadian partners, we are ensuring Canadian innovation leads the global advancement of medicine." Nova Scotia Health received the 2025/26 Aurora Borealis Award. The Aurora Borealis Award celebrates academic institutions and their administrative teams who foster synergetic relationships between industry and academia to drive healthcare innovation. Over the last five years, Nova Scotia Health has partnered on five pan-Canadian R&D projects. Nova Scotia Health also enabled the second Medventions site across Canada, and this year supported the launch of Medventions Atlantic NL in Newfoundland & Labrador. Nova Scotia Health actively champions innovation opportunities and enables the next generation of innovators in Eastern Canada to acquire the skills they need to succeed in medtech. "We're honoured to receive the Aurora Borealis Award from INOVAIT, said Margaret Palmeter, Senior Director of Innovation at Nova Scotia Health. "This recognition reflects the dedication of our teams and partners who work every day to move innovation from idea to impact - quickly, thoughtfully, and in ways that truly support patient care and system needs. At Nova Scotia Health, we're committed to creating the conditions for meaningful collaboration and accelerating projects that improve health outcomes for Nova Scotians." Profound Medical received the 2025/26 Mount Logan Award. This award acknowledges the INOVAIT member who has achieved their project milestones and reached new heights for their company, demonstrating Canada's greatness on the world stage. Profound Medical has achieved significant milestones and international acclaim over the last year, including treating their 4,000th TULSA-PRO patient, securing new U.S. reimbursement codes from Medicare, and establishing strategic partnerships to expand patient access globally. "We are incredibly honoured to receive this award and sincerely thank INOVAIT for supporting AI development of TULSA-PRO as we work to drive widespread global commercialization of this home-grown Canadian medical innovation," said Arun Menawat, Profound Medical's CEO and Chairman. "Toronto's renowned Sunnybrook Health Sciences Centre was the original innovator of the TULSA-PRO technology, and to date, more than 4,000 men around the world have undergone the TULSA Procedure for prostate cancer and/or BPH." Through the INOVAIT Awards, the network continues to amplify the Canadian medtech companies and healthcare institutions that are transforming patient care and advancing medical innovation globally. INOVAIT is supported by the Government of Canada through the Strategic Response Fund.

Colby College
Nov 21st, 2025
Revolutionizing the Technology Behind Drug Development

Revolutionizing the technology behind drug development. Felix Baldauf-Lenschen '14 launched a company devoted to accelerating development of new and effective cancer drugs. The next time you talk to someone who becomes an excitable student of life when a favorite passion is brought up, look in their eyes. The eyes say it all. In a conversation with Felix Baldauf-Lenschen '14, his eyes light up when he discusses AI-enabled medical imaging, which has become the cornerstone innovation for his startup, Altis Labs, a biotechnology company based in Toronto, Ontario. "The earlier you can find out how well a drug is working, the quicker you can get to the next stage of its development," Baldauf-Lenschen said in an interview at his office in the heart of Toronto's MaRS Centre innovation hub. Altis creates software for images taken during a drug's clinical trial so it can optimize them to speed up what researchers need to know: Is the drug helping, or not, to, say, help patients live longer? His eyes dance again when he talks about why he's neck-deep in a sector the economics major never thought he'd dive into. The earlier you know that a drug actually can work, the faster you can get to that phase-three step it needs. "And that means more time on patent, more revenue, more lives saved, more lives prolonged," he said. Known for having one of the world's largest cancer-imaging databases, Altis Labs developed an AI model that analyzes CT scans by quantifying tumors, muscle, fat, and the cardiovascular health of the patient. The system forecasts a score, which ultimately becomes survival-prediction for that patient based on that scan. As clinical trial patients undergo multiple scans during treatment, their score might increase, suggesting treatment response, or decrease, suggesting deterioration. The company primarily focuses on drugs treating lung, breast, prostate, and colorectal cancers. During drug trials on cancer patients, radiologists follow criteria established 25 years ago to make measurements that attempt to anticipate whether the drugs will work, but they can often disagree about the data. With AI technology, there is less opinion and more hard data to predict, for example, if a drug is affecting tumors in some way. "An X-ray is only a 2D image of many vital organs of the chest, so there can be very nuanced findings that on one day a radiologist might see or suspect something, and on another day they might not," Baldauf-Lenschen said. The startup's client list is a who's who of Big Pharma: Johnson & Johnson, AstraZeneca, Bayer, and Debiopharm. In June 2023, four years after it launched, Altis Labs secured $6 million in seed funding. "What really gets me excited about Altis Labs is understanding how to bring down the cost for a company to introduce a new drug to market, which should help everyone," Baldauf-Lenschen said. "And we can even help drug companies fail faster, because the quicker they know their drug isn't working, the faster they can start trials with another drug. That could bring down drug prices, too." He's got a point: Up to 90 percent of all drug trials fail, according to a 2022 paper. Meeting clients in Toronto and on Zoom to talk about medical imaging is a far cry from the life Baldauf-Lenschen, who was born in Germany and raised in Zurich, led years ago, when he dreamed of skiing for a living. Soccer and skiing had long been family pastimes, and Colby caught his eye thanks to its success in skiing, and he thought he could also walk onto the soccer team. "To be part of a small community where athletics was central, that was appealing to me," he recalled. When he arrived on Mayflower Hill, he soon realized skiing was out of the question. "These skiers were very serious, and I couldn't commit in that way," he said, adding that a few injuries also set back his midfielder ambitions. He majored in economics, and Colby's interdisciplinary approach meshed well with his wide-ranging interests. "What I loved about Colby is the opportunity to take classes across so many disciplines," Baldauf-Lenschen said, "from philosophy to music to dance. And back then, no, I never thought I'd start my own company in the medical field." Soon after graduating, he moved to Boston to work as a financial analyst for a company advising commercial banks, delving into predicting the default rate companies might see in their portfolios. The investment firm Cambridge Associates pulled him away from Boston to San Francisco, and he recalled attending many fascinating conferences with healthcare companies focused on digital innovation. A high school classmate from his Zurich days had a neighbor on the board of a medical imaging company that used AI technology to help radiologists be more efficient in diagnosing patients and reviewing scans. When that board member, Sally Daub, stepped in as CEO of Enlitic, she brought on Baldauf-Lenschen as vice president of business development. "That was really exciting to me, to be part of that cutting edge of AI research," he said, eyes aglow again. "We were working on AI models that were detecting lung cancer a year or two prior to a radiologist being able to do the same." Being immersed in radiology gave him an idea. Radiology yields the most comprehensive data in healthcare, but that data was poorly used to predict survival differences, he said. He wondered: Is there a better way to understand how well new drugs are working? In 2019, he cofounded Altis with Daub and moved to Toronto, a city known for its startup community and for nurturing AI talent while also boasting a single-payer healthcare system that centralizes historical imaging data - something that is widely fragmented in the United States. Canadians' easy access to healthcare created a pipeline to fuel Altis Lab's value proposition. When the company analyzes CT scans during drug trials, it outputs IPRO (Imaging-Based Prognostication) scores, which predict if a certain treatment is effective. These scores can inform drug companies whether to progress or stop development of a new treatment that has yet to reach Federal Drug Administration approval. A major test of Altis Labs' promise came when a global pharmaceutical company invited the lab to analyze the efficacy of its new drug approved by the FDA. The company asked back-test Altis' AI model, meaning it re-analyzed the clinical trial using IPRO scores. "We got five million images, did the test within a weekend, and later got a call from the company saying how well we performed and asking if we could begin working on additional cancer drugs they were trialling," Baldauf-Lenschen said. The lab has scanned medical images and found a drug prolonged survival 10 months earlier than traditional radiological interpretation. It's that kind of rich data, delivered at a fraction of the time of manual analysis, that is so attractive to drug companies, he said. Down the road, if IPRO is accepted by regulators, drug developers would be able to get accelerated drug approval months earlier using the lab's software. This space is growing quickly: Cancer medicine spending at list prices surged to $252 billion globally in 2024 and is expected to reach $441 billion by 2029. It's appealing to Baldauf-Lenschen that he can be part of a cresting wave of health-tech breakthroughs, while also learning on the job. "I love how I get to work with our engineering and product teams and recognize how much we have to do to have a model trained with so much data, to have these massive historical data sets," he said. Even their company name is proof of its direction. "In Latin, altis means high or deep, depending on the context, and since we use deep-learning in our AI systems, well, it just felt right," he said with a wide smile and beaming eyes. "And I wanted something short and easy to pronounce."

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