Khona Scientific and EVEXIAS execute Letter of Intent to explore next-generation steroid hormone supply chain. July 30, 2026 Khona Scientific to deploy biomanufacturing tech to produce bioidentical steroid hormones compatible with EVEXIAS' market-leading hormone therapy modalities. BOULDER, CO, UNITED STATES, July 30, 2026 /EINPresswire.com/ - Khona Scientific, a pioneer of biomanufacturing solutions for complex natural product compounds, is excited to announce the signature of a Letter of Intent (LOI) with EVEXIAS, a preeminent provider of hormone replacement and hormone optimization therapies. Through thoughtful planning and rigorous validation, the Companies endeavor to establish the steroid hormone supply chain of tomorrow, today. Steroid hormones are among the most influential chemical messengers in the human body. These molecules impact the function of nearly all organ systems and physiological processes, with critical roles in metabolism, aging, immunity, reproductive systems, bone structure, heart health, and brain function. Accordingly, deficiencies in steroid hormone levels have far-reaching health impacts that can be remedied by treatment with personalized hormone therapies such as those offered by EVEXIAS. Similar to how deficiencies in steroid hormone levels can lead to detrimental effects in patient populations, deficiencies in supply chains for steroid hormones can likewise result in negative impacts for treatment providers like EVEXIAS. These supply issues can be resolved through innovations in steroid hormone manufacturing. Today, such compounds are sourced almost exclusively from India and China. Khona Scientific's expansion into steroid hormones is motivated by the desire to provide partners like EVEXIAS with more choices when sourcing APIs to meet the growing demand from patients and physicians. Establishing resiliency through redundancy is the fundamental objective of the collaboration between Khona Scientific and EVEXIAS. The endeavor centers on the use of Khona Scientific's BiDS(TM) technology to produce bioidentical steroid hormones for integration into EVEXIAS' hormone therapy formulations following rigorous validation. BiDS(TM) is a modular, versatile platform for producing complex active pharmaceutical ingredients (APIs) using abundant, inexpensive, and renewable sugars as feedstocks. The technology is akin to a 'molecular assembly line' - it enhances yield, quality, throughput, and efficiency by physically organizing enzymes from multiple pathways in the optimal sequence within a host cell to produce the target product. This design maximizes the productivity and overcomes the bottlenecks inherent to legacy systems. In turn, this enables scalable, low-cost, on-demand API production that is not beholden to specialized inputs. By decoupling steroid hormone API production from agricultural supply chains, Khona Scientific's BiDS(TM) technology can help EVEXIAS ensure the continuity and consistency of care for patients receiving its personalized hormone therapy regimens. "Our mission has always been to provide patients and physicians with safe, effective, and dependable treatment options" said Dan DeNeui, CEO of EVEXIAS. "We look forward to exploring how Khona Scientific can contribute to this mission by facilitating supply chain diversification for our hormone therapy offerings." Paul Orlady, CEO of Khona Scientific, says, "We are eager to showcase the capabilities of Khona Scientific's technology by delivering a purpose-built production pipeline that will enhance the supply chain for EVEXIAS' industry-leading hormone therapy segment. This constitutes an important first step for the Companies' mutual objective of ensuring better health outcomes for patients seeking relief from a number of conditions." Multiple steroid hormones are encompassed by the LOI, including progesterone, estradiol, estrone, and estriol. Estradiol is a mainstay in the treatment of menopause symptoms such as hot flashes and night sweats and for the prevention of bone deterioration (osteoporosis). Progesterone is frequently combined with estradiol in hormone therapy regimens to treat menopausal symptoms and promote endometrial protection during treatment. Estradiol and progesterone can also be administered in non-menopausal settings including the treatment of infertility, the management of polycystic ovarian syndrome (PCOS), and the application of assisted reproductive technologies.

The Skin Care Center now offering hormone replacement therapy. Kaleigh Gordon, APRN, FNP-C, is now offering hormone replacement therapy for both men and women at The Skin Care Center at Gulf Coast Plastic Surgery. Kaleigh is a personalized hormone and wellness nurse practitioner who will begin seeing patients August 17, 2026. The Skin Care Center partnered with Evexias Healthcare to offer Evexipel pellet insertion, patches, creams, and oral HRT therapy, as well as a full compliment of nutraceuticals to balance hormones, restore energy, and regain confidence. A hormonal imbalance can subtly disrupt every facet of your well-being, affecting your energy levels, mood, metabolism, sleep quality, mental clarity, and libido. For millions of individuals, these pervasive symptoms are often dismissed, misdiagnosed, or ineffectively managed with temporary solutions. The advantage of receiving hormone replacement therapy services at The Skin Care Center is the efficiency of receiving your labs and treatment. Patients are offered the option of having lab work completed prior to the first appointment, so treatment can begin immediately after seeing the provider. The Skin Care Center has created a streamlined process to reduce the need for back-and-forth appointments just to get treatment. Many people prefer Evexipel because of its patented pellet formulation, which integrates a micro-dose of the anti-inflammatory steroid triamcinolone. This unique feature is specifically designed to reduce post-insertion inflammation, prevent the buildup of scar tissue, and decrease the rate of pellet extrusion. Key factors contributing to the preference for EvexiPEL include: Proprietary Formulation: EvexiPEL uses a methylcellulose binding base rather than stearic acid, which allows for a smoother, highly consistent hormone release profile over the pellet's 3-to-6-month lifespan. Minimized Scarring: The addition of triamcinolone and the use of blunt-tipped trocars during insertion trauma-proofs the procedure, minimizing tissue damage and preserving the insertion site for future treatments. Integrated Pharmacy: EvexiPEL pellets are manufactured at FarmaKeio, a dedicated, highly regulated 503B outsourcing facility, which gives the company tight, centralized control over the manufacturing and purity standards of its product. Holistic Philosophy: EvexiPEL focuses heavily on a whole-body wellness approach - utilizing proprietary testing algorithms that pair extensive symptomatology with precise lab work - to offer highly customized hormone dosing. To schedule Midlife & Metabolic services with Nurse Practitioner Kaleigh Gordon, call or text 850-474-0155. Nurse Practitioner Natalie Mabire, APRN, FNP-C, FNP-BC is available for weight loss and wellness consultations and treatment. The Skin Care Center offers a full compliment of vitamin and peptide therapy for recovery and general wellness. Have an injury and need accelerated recovery? Natalie has NAD+. Feeling rundown after a weekend of playing in the sun? There's an IV for that, too! Running low on B12? Come in for a quick and affordable injection. Natalie will provide a full body composition assessment using its brand new Inbody machine, that will assess your overall weight, including details for muscle mass, bone density, water weight, etc. Based on those results, Natalie will work with you to map out a plan to optimize your health. The Skin Care Center also uses VO2 max testing, which measures the maximum amount of oxygen your body uses during intense exercise. It is the gold standard for assessing cardiorespiratory fitness, guiding tailored training programs, and predicting both cardiovascular health and long-term life expectancy. In addition to providing athletes optimized planning, it offers everyone insights on disease prevention. A higher VO2 max is strongly correlated with a reduced risk of cardiovascular disease. Multiple medical studies identify VO2 max as one of the strongest independent predictors of future life expectancy and overall longevity. The V stands for volume and the O2 stands for oxygen. So, in short, in quantifies how much oxygen your body is using while exercising. When you breathe, your lungs absorb oxygen and transport it your red blood cells, which carry the oxygen to all of your body's organs and muscles. Your muscle cells need oxygen to generate adenosine triphosphate (ATP). ATP provides the main energy your muscles need to work. The more oxygen you can breathe in, the more ATP your muscles produce, creating the energy to fuel your muscles. When your VO2 max score is high, that means your heart and lungs are more effectively supplying blood to your muscles. When your VO2 max score is low, it means you need to mix up your workout routine, get more aerobic exercise (consider a HIIT routine). Another way to improve your VO2 max score is by losing weight. While this often seems like a daunting task, its weight loss services with GLP-1 management are an effective way to improve your VO2 max score and add years to your life. You can schedule a consultation with Natalie Mabire by clicking here: Schedule a Wellness Appointment with Natalie. You can also call The Skin Care Center at 850-474-0155. Peter Butler, MD, receives a full InBody evaluation to determine his body composition in a consultation at The Skin Care Center at Gulf Coast Plastic