Generation Bio

Generation Bio

Develops redosable non-viral genetic medicines

Overview

Generation Bio develops genetic medicines using a non-viral platform to treat rare and common diseases. Its core technology combines iqDNA, an immune-quiet DNA, with ctLNP, a cell-targeted lipid nanoparticle delivery system, to deliver genetic payloads to specific tissues. A key part of its approach is rapid enzymatic synthesis (RES), a scalable capsid-free manufacturing process that can produce iqDNA and enable multi-year durability from a single dose while allowing titration and redosing to adjust expression levels. The company aims to scale production to hundreds of millions of doses, expanding access to genetic medicines beyond a small patient population. Unlike many rivals that rely on viral vectors, Generation Bio focuses on non-viral delivery, tissue-specific targeting, and dose-adjustable treatment, with the goal of making durable genetic therapies broadly accessible."} ےOops: user asked to avoid

Significant Headcount Growth

About Generation Bio

Simplify's Rating
Why Generation Bio is rated
D+
Rated C on Competitive Edge
Rated D+ on Growth Potential
Rated D+ on Differentiation

Industries

Biotechnology

Healthcare

Company Size

11-50

Company Stage

IPO

Headquarters

Cambridge, Massachusetts

Founded

2016

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Simplify's Take

What believers are saying

  • XOMA Royalty acquired Generation Bio February 9, 2026, for $4.2913 per share plus CVR.
  • CVR captures 90% Moderna milestones, 70% ctLNP sale proceeds.
  • 90% workforce cut August 2025 and lease end extend cash runway.

What critics are saying

  • XOMA Royalty shelves platforms to monetize assets within 6-12 months.
  • 90% staff loss eliminates R&D expertise for program execution.
  • Moderna terminates ctLNP collaboration, cutting primary CVR revenue.

What makes Generation Bio unique

  • Proprietary iqDNA evades immune detection like mRNA in mice and NHPs.
  • ctLNP enables targeted delivery to extrahepatic tissues beyond liver.
  • RES manufacturing scales to hundreds of millions of doses capsid-free.

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Funding

Total Funding

$521.4M

Above

Industry Average

Funded Over

6 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison
Coming Soon

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

4%

1 year growth

20%

2 year growth

17%
GlobeNewswire
Feb 9th, 2026
XOMA Royalty Announces Closing of Tender Offer and Completed Acquisition of Generation Bio, Inc.

XOMA Royalty announces closing of tender offer and completed acquisition of Generation Bio, inc. Generation Bio stockholders received $4.2913 per share in cash plus a contingent value right. February 09, 2026 09:53 ET | Source: XOMA Royalty Corporation EMERYVILLE, Calif., Feb. 09, 2026 (GLOBE NEWSWIRE) - XOMA Royalty Corporation (NASDAQ: XOMA) ("XOMA Royalty" or the "Company"), a biotechnology royalty aggregator playing a distinctive role in helping biotech companies achieve their goal of improving human health, today announced the Company successfully completed its previously announced tender offer to acquire all outstanding shares of Generation Bio Co. (NASDAQ: GBIO) ("Generation Bio") common stock for a price per share of $4.2913 in cash (the "Cash Amount"), plus one non-tradeable contingent value right ("CVR") (together with the Cash Amount, the "Offer Price") and successfully completed its acquisition of Generation Bio. The tender offer and related withdrawal rights expired one minute after 11:59 p.m. Eastern Time on Friday, February 6, 2026 (the "Expiration Date"). As of the Expiration Date, a total of 4,722,533 shares of Generation Bio common stock were validly tendered, and not validly withdrawn, representing approximately 70% of the outstanding shares of Generation Bio common stock as of the Expiration Date. As of the Expiration Date, the number of shares validly tendered in accordance with the terms of the tender offer and not validly withdrawn satisfied the minimum tender condition, and all other conditions to the tender offer were satisfied or waived. After the Expiration Date, XOMA Royalty irrevocably accepted for payment all shares validly tendered and not validly withdrawn and expects to promptly pay for such shares. Following the closing of the tender offer, a subsidiary of the Company, XRA 7 Corp., merged with and into Generation Bio (the "Merger"), and all shares of Generation Bio common stock that had not been validly tendered and irrevocably accepted for purchase were converted into the right to receive the Offer Price without interest. As a result of the Merger, Generation Bio became a wholly owned subsidiary of XOMA Royalty. Following the closing of trading on The Nasdaq Stock Market LLC ("Nasdaq") on February 6, all shares of Generation Bio common stock ceased trading on Nasdaq, and the Company and Generation Bio intend promptly to cause such shares to be delisted from Nasdaq and deregistered under the Securities Exchange Act of 1934, as amended. Advisors XOMA Royalty was represented by Gibson, Dunn & Crutcher LLP. TD Cowen served as financial advisor, and Wilmer Cutler Pickering Hale and Dorr LLP served as legal counsel to Generation Bio. About XOMA Royalty Corporation XOMA Royalty is a biotechnology royalty aggregator playing a distinctive role in helping biotech companies achieve their goal of improving human health. XOMA Royalty acquires the potential future economics associated with pre-commercial and commercial therapeutic candidates that have been licensed to pharmaceutical or biotechnology companies. When XOMA Royalty acquires the future economics, the seller receives non-dilutive, non-recourse funding they can use to advance their internal drug candidate(s) or for general corporate purposes. XOMA Royalty has an extensive and growing portfolio of assets (asset defined as the right to receive potential future economics associated with the advancement of an underlying therapeutic candidate). For more information about XOMA Royalty and its portfolio, please visit www.xoma.com or follow XOMA Royalty Corporation on LinkedIn. Forward-Looking Statements/Explanatory Notes Certain statements contained in this press release are forward-looking statements, including statements regarding the payment and expected timing of payment of the tender offer, the delisting and deregistration of Generation Bio common stock, the ability of XOMA Royalty to monetize Generation Bio's delivery platform for the benefit of XOMA Royalty and Generation Bio stockholders, and the ability to achieve any dispositions within the disposition period under the CVR Agreement. In some cases, you can identify such forward-looking statements by terminology such as "anticipate," "approximately," "look to," "plan," "expect," "may," "will," "could" or "should," the negative of these terms or similar expressions. These forward-looking statements are not a guarantee of XOMA Royalty's performance, and you should not place undue reliance on such statements. These statements are based on assumptions that may not prove accurate, and actual results could differ materially from those anticipated due to certain risks including the risk that XOMA Royalty does not achieve anticipated net cash after winding down Generation Bio's operations and concluding remaining activities, and the risk that XOMA Royalty is unable to develop or otherwise enter into dispositions related to the Generation Bio programs. Other potential risks to XOMA Royalty meeting these expectations are described in more detail in XOMA Royalty's most recent filing on Form 10-Q and in other filings with the Securities and Exchange Commission. Any forward-looking statement in this press release represents XOMA Royalty's beliefs and assumptions only as of the date of this press release and should not be relied upon as representing its views as of any subsequent date. XOMA Royalty disclaims any obligation to update any forward-looking statement, except as required by applicable law. EXPLANATORY NOTE: Any references to "portfolio" in this press release refer strictly to milestone and/or royalty rights associated with a basket of drug products in development. Any references to "assets" in this press release refer strictly to milestone and/or royalty rights associated with individual drug products in development. | XOMA Royalty Investor Contact Juliane Snowden XOMA Royalty Corporation +1-646-468-9754 [email protected] | / | XOMA Royalty Media Contact Kathy Vincent KV Consulting & Management [email protected] |

XOMA Royalty Corporation
Dec 16th, 2025
XOMA Royalty Enters into Agreement to Acquire Generation Bio

XOMA Royalty has built a significant portfolio of products that are licensed to and being developed by other biotechnology and pharmaceutical companies.  The Company’s portfolio of partner-funded programs spans multiple stages of the…

Stock Titan
Dec 15th, 2025
XOMA Royalty to acquire Generation Bio for $4.29 per share plus CVR tied to Moderna milestones

XOMA Royalty has agreed to acquire Generation Bio for $4.2913 per share in cash plus one contingent value right per share. The CVR entitles holders to pro rata payments from net cash exceeding $29 million, 90–100% of Cambridge office lease savings, up to 90% of proceeds from Generation Bio's Moderna licence milestones and royalties, and up to 70% of proceeds from any out-licence or sale of Generation Bio's ctLNP delivery platform. The transaction will begin with a tender offer within 15 business days and requires a majority tender to close. Approximately 15% of shares are under support agreements to tender. The acquisition is expected to complete in February 2026. The deal follows Generation Bio's strategic review, which included a 90% workforce reduction announced in August 2025.

BioSpace
Feb 27th, 2025
Generation Bio To Present At The Td Cowen 45Th Annual Health Care Conference

CAMBRIDGE, Mass., Feb. 24, 2025 (GLOBE NEWSWIRE) -- Generation Bio Co. (Nasdaq:GBIO), a biotechnology company working to change what’s possible for people living with T cell-driven autoimmune diseases, announced that Geoff McDonough, M.D., president and chief executive officer, will present at the TD Cowen 45th Annual Health Care Conference on Monday, March 3, 2025 at 9:10 a.m. ET in Boston. A live webcast of the presentation will be available on the investor section of the company’s website at investors.generationbio.com. A replay will be available there for 30 days following the event

BioSpace
Apr 2nd, 2024
Generation Bio To Present At The 23Rd Annual Needham Virtual Healthcare Conference

CAMBRIDGE, Mass., April 02, 2024 (GLOBE NEWSWIRE) -- Generation Bio Co. (Nasdaq:GBIO) a biotechnology company innovating genetic medicines for people living with rare and prevalent diseases, announced that Geoff McDonough, M.D., president and chief executive officer, will participate in a fireside chat at the 23rd Annual Needham Virtual Healthcare Conference on Tuesday, April 9, 2024 at 12:45 p.m. ET.A live webcast of the presentation will be available on the investor section of the company’s website at investors.generationbio.com. A replay will be available there for 30 days following the event.About Generation BioGeneration Bio is innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases. The company is developing two distinct and complementary platforms: a potent, highly selective cell-targeted lipid nanoparticle (ctLNP) delivery system and a novel immune-quiet DNA (iqDNA) cargo produced by a scalable capsid-free manufacturing process that uses proprietary cell-free rapid enzymatic synthesis (RES). With these platforms, Generation Bio aims to develop the next wave of non-viral genetic medicines to support its mission to extend the reach of genetic medicine to more people living with more diseases, around the world.For more information, please visit www.generationbio.com.Investors and Media Contact

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