RegCell has secured $44 million in Series A funding to advance regulatory T cell therapies into clinical trials. The biotech was founded by Nobel laureate Shimon Sakaguchi, who has spent nearly 50 years researching how regulatory T cells help the immune system govern itself. RegCell is now a decade old and preparing to move its treatments based on Sakaguchi's work into clinical development. The funding will support the company's efforts to translate research on these immune cells into potential therapies for patients.

Global Brain's Fund No. 9 has invested in 10pct., a Tokyo-based company that operates and manages hotels and inns using AI and data analytics. Global Brain served as lead investor in the round, though no funding amount was disclosed. 10pct. addresses challenges in Japan's tourism industry, including overtourism in major cities and labour shortages, whilst regional areas with tourism potential struggle with ageing infrastructure and insufficient management expertise. The company operates hotels and inns across locations including Kyoto, Hakuba, and Minakami Onsen. It has developed a hotel management DX platform featuring AI-driven demand forecasting, automated pricing adjustments, and direct booking optimisation. 10pct. also provides M&A advisory services for accommodation facilities and works with local governments and destination marketing organisations on area branding and promotion initiatives. Founded in July 2023, the company is led by CEO Tomoyoshi Nakahori.

Reframe Systems, a physical AI company industrialising homebuilding, has raised $40 million in venture-backed equity financing. The round was led by Energy Impact Partners, with participation from Counterpart Ventures, E12 Ventures, Global Brain, Thin Line Capital, Up Partners, LACI Impact Fund, and existing investors including Eclipse and VoLo Earth. The company builds small, highly automated microfactories near communities requiring housing. Its technology delivers homes three times faster and at 35% lower cost than traditional construction. Reframe has completed 10 homes and expects to deliver 114 additional units over the next year. The funding will support expansion of Reframe's microfactory network across North America. The company's new Massachusetts facility, FAB1, is designed to produce up to 500 multifamily units or 250 single-family homes annually with less than $5 million in equipment.