Helical

Helical

Open-source platform enabling bio foundation models

Overview

Helical AI provides an open-source platform to accelerate drug development using bio foundation models for researchers, biologists, and developers. The platform lets users explore, fine-tune models on proprietary data, and build predictive applications that stay biologically relevant. It serves pharmaceutical and biotech customers with turnkey applications, customized data fine-tuning, and guided predictions, charging enterprise subscriptions, early access, and tailored solutions. Its advantage comes from combining an open-source base with enterprise-ready features so non-AI teams can apply advanced bio models without building everything from scratch, speeding up drug discovery.

About Helical

Simplify's Rating
Why Helical is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Enterprise Software

AI & Machine Learning

Biotechnology

Healthcare

Company Size

11-50

Company Stage

Seed

Total Funding

$12.4M

Headquarters

Luxembourg, Luxembourg

Founded

2023

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Simplify's Take

What believers are saying

  • May 2026 Pfizer collaboration moved Helical into production biomarker discovery.
  • April 2026 seed funding from redalpine, Gradient, BoxGroup, and Frst finances expansion.
  • LinkedIn and job boards show active hiring for platform, ML, and scientific roles.

What critics are saying

  • Recursion, Sanofi, and Roche own deeper data moats and clinical validation by 2026.
  • Helical's 11-50 person team risks services-heavy scaling before product standardization hardens.
  • If top-20 pharma pilots fail to convert into multi-year contracts, revenue disappears quickly.

What makes Helical unique

  • Helical sells a virtual AI lab, not another model wrapper, for pharma workflows.
  • Its evidence layer makes in-silico experiments reproducible, auditable, and biologically grounded.
  • Pfizer collaboration and top-20 pharma deployments prove enterprise-grade integration, not demos.

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Funding

Total Funding

$12.4M

Above

Industry Average

Funded Over

2 Rounds

Notable Investors:
Seed funding is usually the first official round after pre-seed, when a startup has a prototype or concept. It’s typically used to develop the product, test the market, and start building the team. Investors here are often angel investors or early-stage venture capitalists.
Seed Funding Comparison
Above Average

Industry standards

$3.3M
$2M
Netflix
$2.3M
Instacart
$3M
Robinhood
$10M
Helical

Benefits

Company Equity

Growth & Insights and Company News

Headcount

6 month growth

-7%

1 year growth

-7%

2 year growth

41%
Vestbee
Apr 15th, 2026
UK's biotech startup Helical raises $10M to build a virtual AI lab for drug discovery.

UK's biotech startup Helical raises $10M to build a virtual AI lab for drug discovery. UK-based biotech startup Helical, which builds a virtual AI lab for faster AI-driven drug discovery, has raised $10 million in seed funding led by redalpine to scale its platform for pharmaceutical research. * Founded in 2024 by Rick Schneider, Maxime Allard, and Mathieu Klop, Helical builds a virtual AI lab that turns biological foundation models into reproducible drug discovery workflows used by pharmaceutical R&D teams. * Instead of relying on traditional lab-only experimentation, Helical lets researchers run in-silico experiments, meaning they can test biological hypotheses computationally at scale before validating them in the physical lab. Its platform is split into two core systems: a "Virtual Lab" for biologists to design and evaluate experiments, and a "Model Factory" for ML engineers to train, personalise, and deploy biology-focused AI models. * The system works by connecting large biological foundation models with structured experimental workflows, allowing predictions to be tested, tracked, and validated against real biological evidence so teams can move from hypothesis to decision faster and more reproducibly. Details of the deal. * The round was led by redalpine, with participation from Gradient, BoxGroup, Frst, and several angel investors including Aidan Gomez, Clément Delangue, Ivan Zhang, and Mario Götze. "Helical is already working with a number of top-20 pharma companies, including a public collaboration with Pfizer on predictive safety biomarkers that compresses discovery timelines from years to weeks. The funding will accelerate their expansion to additional top-20 pharma organizations. Congratulations to Rick, Maxime, Mathieu, and the whole Helical team," redalpine's team, commented on LinkedIn. * The new capital will be used to expand Helical's platform across pharmaceutical clients, deepen deployments in drug discovery use cases, and further develop its "evidence layer" to make in-silico experiments more reliable, reproducible, and scalable across diseases and therapeutic areas.

The Next Web
Apr 14th, 2026
Helical closes $10M seed to turn bio foundation models into systems.

Helical closes $10M seed to turn bio foundation models into systems. April 14, 2026 - 12:00 pm The Luxembourg-founded startup is already in production with multiple top-20 global pharma companies, including a public collaboration with Pfizer. Its $10M seed round is led by redalpine, with the CEOs of Cohere and HuggingFace among the angel investors. Helical, a London-based pharma AI startup founded by three Luxembourgish childhood friends, has raised $10 million in a seed round led by redalpine, with participation from Gradient, BoxGroup, and Frst. Notable angel investors include Aidan Gomez, CEO of Cohere; Clément Delangue, CEO of HuggingFace; and Mario Goetze, a professional footballer. The funding will support expansion across more top-20 pharma programmes and growth of Helical's deployed science and engineering team. The company was founded by Rick Schneider, Maxime Allard, and Mathieu Klop, three school friends who took divergent paths into the same problem. Schneider built technology at Amazon before helping the German enterprise software company Celonis scale operations in France and Japan. Allard led data science teams at IBM before pursuing a PhD focused on reinforcement learning and robotics. Klop became a cardiologist and genomics researcher. When biological foundation models began emerging, the trio identified the same gap: models capable of transforming how pharma discovers drugs were arriving faster than the application infrastructure needed to make them usable at scale. Helical's thesis is that bio foundation models, AI systems trained on vast genomic, transcriptomic, and proteomic datasets, have already crossed a quality threshold that makes computational hypothesis-testing meaningful in pharma research. What has not kept pace is the layer between a model's output and a scientific decision. In practice, this means bench scientists and ML engineers working in separate environments, teams recreating one-off notebooks for each programme, and analysis that is difficult to reproduce or transfer across disease areas. Helical builds the infrastructure that closes that gap. Its platform has two surfaces: a Virtual Lab for biologists and translational scientists, and a Model Factory for ML engineers and data scientists, both running on shared data and models to produce consistent, auditable results. The company is already in production with multiple top-20 global pharma companies. Its publicly disclosed collaborations include work with Pfizer on predictive blood-based safety biomarkers, and with Tanabe Pharma America on AI-driven target discovery for neurodegenerative diseases including ALS. Across those deployments, Helical says teams have compressed discovery timelines from years to weeks. The broader industry context gives the ambition some scale: global pharma R&D spending exceeds $300 billion annually, bringing a single drug to market costs more than $2 billion on average, timelines stretch beyond a decade, and more than 90% of candidates entering clinical trials fail to reach approval. Daniel Graf, General Partner at redalpine, described the investment as a bet on a transition "from siloed AI models to integrated virtual AI labs" as biological foundation models and general language reasoning converge. The round builds on a prior €2.2 million raise in 2024 from Frst, BoxGroup, and angels including Gomez and Delangue, who return as investors in this round as well.

Health Tech Digital
Apr 13th, 2026
Helical raises $10M to turn bio foundation models into reproducible pharma discovery workflows

Helical, a virtual AI lab for pharmaceutical research, has raised $10 million in seed funding led by redalpine, with participation from Gradient, BoxGroup, Frst and notable angels including Cohere CEO Aidan Gomez and HuggingFace CEO Clement Delangue. Founded in early 2024, Helical provides an application layer that converts biological foundation models into reproducible discovery workflows for pharma companies. The platform features two surfaces: the Virtual Lab for biologists and the Model Factory for ML engineers, enabling teams to test hypotheses computationally before wet lab experimentation. The company is already deployed at multiple top-20 pharma firms, including a public collaboration with Pfizer on predictive blood-based safety biomarkers. Teams have compressed discovery timelines from years to weeks across target identification, biomarker discovery and therapeutic design programmes.

Helical
Jun 28th, 2024
Helical raises 2.2M€ to accelerate its mission of democratizing DNA and RNA foundation models — Helical

Helical, a Luxembourgish AI-for-bio startup, announces that it has raised 2.2M€ to build the first open-source platform around large language models, enabling data scientists and computational biologists to effortlessly integrate all of those models and build a wide range of drug discovery applicati

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