Keros Therapeutics has seen analysts cut their price target to $21.20 following disappointing first-quarter results. The biotechnology company's revenues of $367,000 fell 78% short of expectations, whilst statutory losses were 18% larger than forecast at $1.21 per share. Analysts now expect revenues of $3.96 million in 2026, representing an 88% decline compared to the last 12 months. Per-share losses are forecast to increase to $6.36. The consensus price target fell 7.8%, with estimates ranging from $16.00 to $30.00. The company's revenue is expected to decline at a 94% annualised rate through 2026, a stark reversal from 72% historical growth over the past five years. This compares unfavourably to the wider industry, where companies are expected to grow revenues by 22% annually.

Keros Therapeutics reports recent First Quarter 2026 Financial Results. LEXINGTON, Mass., May 14, 2026 (GLOBE NEWSWIRE) - Keros Therapeutics, Inc. ("Keros" or the "Company") (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta ("TGF-ß") family of proteins, today reported financial results for the quarter ended March 31, 2026. "Continuing to progress our pipeline remains our top priority, setting the stage for future catalysts and growth opportunities," said Jasbir S. Seehra, Ph.D., President and Chief Executive Officer. "In addition, we are excited that our partner, Takeda Pharmaceuticals U.S.A., Inc. ("Takeda"), plans to advance elritercept into a Phase 3 clinical trial to evaluate elritercept as a treatment of anemia in myelofibrosis, broadening the indication opportunity beyond myelodysplastic syndromes." First Quarter 2026 Financial Results Keros reported a net loss of $23.7 million in the first quarter of 2026 as compared to a net income of $148.5 million in the first quarter of 2025. The decrease of $172.2 million was largely due to revenue recognized in 2025 related to Keros' license agreement with Takeda and decreased research and development efforts. Research and development expenses were $16.1 million for the first quarter of 2026 as compared to $48.7 million for the same period in 2025. The decrease of $32.6 million was primarily due to the transition of elritercept-related research and development expenses to Takeda and the corporate restructuring that was completed in 2025. General and administrative expenses were $10.1 million for the first quarter of 2026 as compared to $10.5 million for the same period in 2025. The decrease of $0.4 million was primarily due to a decrease in compensation costs in connection with the 2025 corporate restructuring. Keros' cash and cash equivalents as of March 31, 2026 was $281.5 million compared to $287.4 million as of December 31, 2025. Based on current operating assumptions, Keros expects that its cash and cash equivalents as of March 31, 2026 will enable Keros to fund its operating expenses and capital expenditure requirements into the first half of 2028. About Keros Therapeutics, Inc. Keros is a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the TGF-ß family of proteins. Keros is a leader in understanding the role of the TGF-ß family of proteins, which are master regulators of the growth, repair and maintenance of a number of tissues, including skeletal muscle, bone, adipose, heart tissue and blood. By leveraging this understanding, Keros has discovered and is developing protein therapeutics that have the potential to provide meaningful and potentially disease-modifying benefit to patients. Keros' lead product candidate, rinvatercept, is being developed for the treatment of Duchenne muscular dystrophy and for the treatment of amyotrophic lateral sclerosis. Keros' most advanced product candidate, elritercept, is being developed for the treatment of cytopenias, including anemia and thrombocytopenia, in patients with myelodysplastic syndrome and in patients with myelofibrosis. Cautionary Note Regarding Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Words such as "continue", "expect", "plan", "look forward to", "will", "potential" or similar expressions are intended to identify forward-looking statements. Examples of these forward-looking statements include statements concerning: Keros' expectations regarding its growth, strategy, progress and the design, objectives and timing of its clinical trials for rinvatercept and elritercept; Takeda's plans to advance elritercept into a Phase 3 clinical trial to evaluate elritercept as a treatment of anemia in myelofibrosis; and Keros' expected cash runway. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties include, among others: Keros' limited operating history and historical losses; Keros' ability to raise additional funding to complete the development and any commercialization of its product candidates; Keros' dependence on the success of its product candidates, rinvatercept and elritercept; that Keros may be delayed in initiating, enrolling or completing any clinical trials; competition from third parties that are developing products for similar uses; Keros' ability to obtain, maintain and protect its intellectual property; and Keros' dependence on third parties in connection with manufacturing, clinical trials and preclinical studies. These and other risks are described more fully in Keros' filings with the Securities and Exchange Commission ("SEC"), including the "Risk Factors" section of the Company's Annual Report on Form 10-K, filed with the SEC on March 4, 2026, and its other documents subsequently filed with or furnished to the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except to the extent required by law, Keros undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Investor Contact: Justin Frantz [email protected] 617-221-6042 | KEROS THERAPEUTICS, INC. Condensed Consolidated Statements of Operations (In thousands, except share and per share data) (Unaudited) | | / | THREE MONTHS ENDED MARCH 31, | | / | 2026 | / | / | / | 2025 | / | | REVENUE: | / | / | / | | Service and other revenue | / | 367 | / | / | / | 15,891 | / | | License revenue | / | - | / | / | / | 195,355 | / | | Total revenue | / | 367 | / | / | / | 211,246 | / | | OPERATING EXPENSES: | / | / | / | | Research and development | / | (16,097 |) | / | / | (48,709 |) | | General and administrative | / | (10,147 |) | / | / | (10,497 |) | | Total operating expenses | / | (26,244 |) | / | / | (59,206 |) | | INCOME (LOSS) FROM OPERATIONS | / | (25,877 |) | / | / | 152,040 | / | | OTHER INCOME (EXPENSE), NET | / | / | / | | Dividend income | / | 2,335 | / | / | / | 6,792 | / | | Other expense, net | / | (166 |) | / | / | (338 |) | | Total other income, net | / | 2,169 | / | / | / | 6,454 | / | | Income (loss) before income taxes | / | (23,708 |) | / | / | 158,494 | / | | Income tax provision | / | - | / | / | / | (10,043 |) | | Net income (loss) | $ | (23,708 |) | / | $ | 148,451 | / | | Net income (loss) attributable to common stockholders - basic and diluted | $ | (23,708 |) | / | $ | 148,451 | / | | Weighted-average shares of common stock outstanding - basic | / | 19,629,906 | / | / | / | 40,559,355 | / | | Weighted-average shares of common stock outstanding - diluted | / | 19,629,906 | / | / | / | 41,021,325 | / | | Net income (loss) per share of common stock - basic | $ | (1.21 |) | / | $ | 3.66 | / | | Net income (loss) per share of common stock - diluted | $ | (1.21 |) | / | $ | 3.62 | / | | / | | KEROS THERAPEUTICS, INC. Condensed Consolidated Balance Sheets (In thousands, except share and per share data) (Unaudited) | | / | MARCH 31, 2026 | / | DECEMBER 31, 2025 | | ASSETS | / | / | / | | CURRENT ASSETS: | / | / | / | | Cash and cash equivalents | 281,497 | / | / | 287,415 | / | | Accounts receivable | 400 | / | / | 3,567 | / | | Prepaid expenses and other current assets | 6,530 | / | / | 22,202 | / | | Current income tax receivable | 2,250 | / | / | 2,250 | / | | Total current assets | 290,677 | / | / | 315,434 | / | | Operating lease right-of-use assets | 16,205 | / | / | 16,841 | / | | Property and equipment, net | 3,962 | / | / | 4,297 | / | | Restricted cash | 1,449 | / | / | 1,449 | / | | TOTAL ASSETS | 312,293 | / | / | 338,021 | / | | LIABILITIES AND STOCKHOLDERS' EQUITY | / | / | / | | CURRENT LIABILITIES: | / | / | / | | Accounts payable | 1,493 | / | / | 1,967 | / | | Current portion of operating lease liabilities | 2,501 | / | / | 2,408 | / | | Accrued expenses and other current liabilities | 8,859 | / | / | 16,039 | / | | Total current liabilities | 12,853 | / | / | 20,414 | / | | Operating lease liabilities, net of current portion | 13,810 | / | / | 14,475 | / | | Total liabilities | 26,663 | / | / | 34,889 | / | | STOCKHOLDERS' EQUITY: | / | / | / | | Preferred stock, par value of $0.0001 per share; 10,000,000 shares authorized as of March 31, 2026 and December 31, 2025; no shares issued and outstanding | - | / | / | - | / | | Series A junior participating preferred stock, par value of $0.0001 per share; 500,000 authorized as of March 31, 2026 and December 31, 2025; no shares issued and outstanding | - | / | / | - | / | | Common stock, par value of $0.0001 per share; 200,000,000 shares authorized as of March 31, 2026 and December 31, 2025; 40,859,597 shares issued and 19,732,837 shares outstanding as of March 31, 2026 and 40,670,466 shares issued and 19,543,706 shares outstanding as of December 31, 2025 | 4 | / | / | 4 | / | | Treasury stock, at cost; 21,126,760 shares as of March 31, 2026 and December 31, 2025 | (384,558 |) | / | (384,558 |) | | Additional paid-in capital | 1,175,657 | / | / | 1,169,451 | / | | Accumulated deficit | (505,473 |) | / | (481,765 |) | | Total stockholders' equity | 285,630 | / | / | 303,132 | / | | TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY | 312,293 | / | / | 338,021 | / |

Keros Therapeutics posted revenue of $244.1 million in 2025, up from $3.6 million in 2024, driven primarily by a $200 million upfront payment and milestone from its Takeda partnership for elritercept. The company has yet to record product sales. Revenue quality remains a concern. Fourth-quarter revenue fell to just $400,000, consisting entirely of transition services with no licence revenue recognised. The top line depends on partner economics and milestone timing rather than commercial sales, creating volatility risk. Following the Takeda transition, Keros has reduced its cost base significantly. Research and development expenses dropped 61% year-over-year in the fourth quarter to $17.9 million as development responsibilities shifted to Takeda. The shares trade at a discount to book value, raising questions about whether the stock represents deep value or a value trap.