Lirio

Lirio

Behavioral-AI health engagement personalisation engine

Overview

Lirio uses behavioral science and AI to improve patient engagement and health outcomes. Its Precision Nudging personalisation engine analyzes individual behaviors, communication patterns, and social/clinical context to deliver hyper-personalized messages and interventions that encourage adherence and screenings. By moving beyond demographics, it enables real-time, one-to-one outreach to sustain engagement across care journeys, partnering with health systems, payers, and provider organizations. The goal is to reduce gaps in care and lower total cost of care by guiding patients through their evolving healthcare journey.

About Lirio

Simplify's Rating
Why Lirio is rated
C
Rated C on Competitive Edge
Rated B on Growth Potential
Rated D+ on Differentiation

Industries

Data & Analytics

Enterprise Software

AI & Machine Learning

Healthcare

Company Size

51-200

Company Stage

N/A

Total Funding

$33.1M

Headquarters

Knoxville, Tennessee

Founded

2017

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Simplify's Take

What believers are saying

  • July 30, 2025 Cone Health partnership expands Lirio into a large North Carolina health system.
  • December 22, 2025 Inc. Best in Business recognition strengthens sales credibility with buyers.
  • August 2026 website claims healthcare's only behavioral science plus agentic AI platform, supporting differentiation.

What critics are saying

  • May 19, 2026 Form D shows only $1.6 million raised against a $20 million offering.
  • Glassdoor ratings fell 7% by July 4, 2025, signaling retention and execution strain.
  • Limited public customer disclosures hide revenue concentration; one failed health-system renewal damages survival.

What makes Lirio unique

  • October 16, 2025 Microsoft Marketplace listing gives Lirio enterprise distribution and Azure trust.
  • October 28, 2025 Life Sciences launch extends Precision Nudging across drug development and adherence.
  • Lirio combines behavioral science with agentic AI, not generic segmentation, for one-to-one health nudges.

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Funding

Total Funding

$33.1M

Above

Industry Average

Funded Over

4 Rounds

Convertible funding comparison data is currently unavailable. We're working to provide this information soon!
Convertible Funding Comparison
Coming Soon

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

401(k) Company Match

10 paid holidays + holiday week company closure

Unlimited Paid Time Off

Hybrid Work Options

Growth & Insights and Company News

Headcount

6 month growth

↑ 0%

1 year growth

↑ 0%

2 year growth

↑ 0%
Business Wire
Feb 5th, 2026
Life sciences firms struggle with patient engagement as 70% cite adherence challenges costing $100B annually

Lirio, a behavioural science and AI platform, has released research revealing that traditional personalisation approaches in life sciences fail to improve patient engagement. The survey of over 75 life sciences executives, conducted by Sage Growth Partners, found that more than 70% identified clinical trial engagement and medication adherence as persistent challenges. The report highlights that nearly 50% of patients don't take medications as prescribed, contributing to $100 billion in annual preventable healthcare costs and 125,000 avoidable deaths. Despite growing direct-to-consumer strategies, only half of organisations use digital health technologies for patient engagement, and fewer than 3% partner with specialised vendors. The findings come as new regulations reshape pharmaceutical advertising, prompting life sciences companies to rethink patient engagement strategies beyond traditional mass messaging approaches.

Teknovation.biz
May 5th, 2025
Lirio Releases Report Titled (Re)Defining Personalization

Lirio, the Knoxville-based pioneer in the union of behavioral science and artificial intelligence to deliver better health outcomes, has released new industry findings on the significant impact that advanced health... The post Lirio releases report titled (Re)defining Personalization appeared first on Teknovation.biz.

U.S. Securities and Exchange Commission
May 2nd, 2025
SEC FORM D

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.The reader should not assume that the information is accurate and complete.

U.S. Securities and Exchange Commission
May 2nd, 2025
SEC FORM D/A

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.The reader should not assume that the information is accurate and complete.

Silverwood Partners
Feb 8th, 2024
Healthcare Private Placement and M&A Transactions Review Week Ending Feb 4, 2024 | Silverwood Partners

Strategy | Financing Transactions Private Placement / Financing Transactions Cellanome: The company raised $150 million of Series B venture funding from Premji Invest (US) and undisclosed investors on January 29, 2024, putting the company’s pre-money valuation at $375 million. The company is a developer of a unique multi-omics platform designed to measure biology at an unprecedented […]

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