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Lirio

Behavioral-AI health engagement personalisation engine

Overview

Lirio applies behavioral science and AI to improve patient engagement and health outcomes. Its Precision Nudging personalization engine analyzes individual behavior, communication patterns, and clinical context to deliver tailored messages and interventions that encourage care and adherence. The platform moves beyond basic demographics to provide one-to-one personalization with real-time adaptation for healthcare providers, payers, and organizations aiming to close care gaps and reduce costs. Originating from Fiveworx, Lirio leverages a utilities-to-healthcare lineage to orchestrate each person's evolving healthcare journey with timely, targeted outreach.

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About Lirio

Simplify's Rating
Why Lirio is rated
C+
Rated C on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & AnalyticsEnterprise SoftwareAI & Machine LearningHealthcare

Company Size

51-200

Company Stage

N/A

Total Funding

$33.1M

Headquarters

Knoxville, TN

Founded

2017

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What believers are saying

  • October 19, 2026 vaccination results validate measurable ROI across a leading U.S. retail pharmacy network.
  • December 2025 health-system survey shows 75 executives want better patient-level personalization.
  • September 2026 PAIHA membership expands partnerships across payers, pharma, providers, and governments.

What critics are saying

  • Large health systems can build similar messaging with Epic, Salesforce, and in-house teams by 2027.
  • Life sciences buyers already rely on internal workflows; Lirio's moat narrows as Microsoft Marketplace commoditizes tools.
  • No funding disclosure, layoffs, or acquisitions surfaced in 2026; capital scarcity can cripple sales expansion.

What makes Lirio unique

  • Behavioral science plus AI powers Precision Nudging®, not generic segmentation.
  • October 2026 pharmacy program reached millions; 40% vaccinated versus standard messaging.
  • Lirio combines healthcare and utility engagement DNA through Fiveworx lineage.

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Funding

Total Funding

$33.1M

Above

Industry Average

Funded Over

4 Rounds

Convertible funding comparison data is currently unavailable. We're working to provide this information soon!
Convertible Funding Comparison Coming Soon

Benefits

  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Life Insurance
  • Disability Insurance
  • 401(k) Company Match
  • 10 paid holidays + holiday week company closure
  • Unlimited Paid Time Off
  • Hybrid Work Options

Growth & Insights and Company News

6 month growth

1%

1 year growth

0%

2 year growth

0%
Business Wire
Feb 5th, 2026
Life sciences firms struggle with patient engagement as 70% cite adherence challenges costing $100B annually

Lirio, a behavioural science and AI platform, has released research revealing that traditional personalisation approaches in life sciences fail to improve patient engagement. The survey of over 75 life sciences executives, conducted by Sage Growth Partners, found that more than 70% identified clinical trial engagement and medication adherence as persistent challenges. The report highlights that nearly 50% of patients don't take medications as prescribed, contributing to $100 billion in annual preventable healthcare costs and 125,000 avoidable deaths. Despite growing direct-to-consumer strategies, only half of organisations use digital health technologies for patient engagement, and fewer than 3% partner with specialised vendors. The findings come as new regulations reshape pharmaceutical advertising, prompting life sciences companies to rethink patient engagement strategies beyond traditional mass messaging approaches.

Teknovation.biz
May 5th, 2025
Lirio Releases Report Titled (Re)Defining Personalization

Lirio, the Knoxville-based pioneer in the union of behavioral science and artificial intelligence to deliver better health outcomes, has released new industry findings on the significant impact that advanced health... The post Lirio releases report titled (Re)defining Personalization appeared first on Teknovation.biz.

U.S. Securities and Exchange Commission
May 2nd, 2025
SEC FORM D

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.The reader should not assume that the information is accurate and complete.

U.S. Securities and Exchange Commission
May 2nd, 2025
SEC FORM D/A

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.The reader should not assume that the information is accurate and complete.

Silverwood Partners
Feb 8th, 2024
Healthcare Private Placement and M&A Transactions Review Week Ending Feb 4, 2024 | Silverwood Partners

Strategy | Financing Transactions Private Placement / Financing Transactions Cellanome: The company raised $150 million of Series B venture funding from Premji Invest (US) and undisclosed investors on January 29, 2024, putting the company’s pre-money valuation at $375 million. The company is a developer of a unique multi-omics platform designed to measure biology at an unprecedented […]

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