Nautilus Biotechnology

Nautilus Biotechnology

Proteomics platform for drug target prioritization

Overview

Nautilus Biotechnology develops a proteomics platform that maps the human proteome to speed up drug discovery. The platform analyzes thousands of proteins across biological samples to reveal which drug targets are most likely to succeed in clinical trials, helping researchers prioritize targets with higher potential. The company sells the platform and related services to pharmaceutical companies, research institutions, and biotech firms, operating on a B2B model. Unlike tools that focus only on genes or small-molecule data, Nautilus provides direct protein-level insights at large scale, combining deep proteome coverage with analytics to reduce time and costs in target discovery. Its goal is to unlock the proteome to enable breakthroughs in biology and medicine and to improve global health outcomes by accelerating and improving drug development.

About Nautilus Biotechnology

Simplify's Rating
Why Nautilus Biotechnology is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

Enterprise Software

Biotechnology

Healthcare

Company Size

51-200

Company Stage

IPO

Headquarters

San Carlos, California

Founded

2016

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Simplify's Take

What believers are saying

  • Nautilus ended Q1 2026 with $143.4 million cash and runway through 2027.
  • Q1 2026 operating expenses fell 14%, showing tighter burn before launch.
  • Management still targets pre-orders late 2026 and customer installations in early 2027.

What critics are saying

  • Nautilus still expects roughly $0.5 million 2026 revenue; commercialization remains unproven.
  • Thermo Fisher's Olink, Danaher, Bruker, and Illumina crowd proteomics with deeper distribution.
  • Voyager's technical failure or missed validation would kill the company before meaningful revenue.

What makes Nautilus Biotechnology unique

  • Voyager measures intact proteins and proteoforms at single-molecule resolution, not peptide fragments.
  • Baylor College of Medicine adopted Nautilus's early access tau assay in March 2026.
  • Amber Faust joined from Olink and SomaLogic, signaling serious proteomics commercialization expertise.

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Funding

Total Funding

$453.2M

Above

Industry Average

Funded Over

4 Rounds

Notable Investors:
Spac IPO funding comparison data is currently unavailable. We're working to provide this information soon!
Spac IPO Funding Comparison
Coming Soon

Benefits

Hybrid Work Options

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

5%

2 year growth

0%
Associated Press
Apr 28th, 2026
Nautilus Biotechnology posts $14.7M Q1 loss, cuts operating costs 14% while launching proteomics early access programme

Nautilus Biotechnology, a company developing a single-molecule proteome analysis platform, reported a net loss of $14.7 million for the first quarter of 2026, compared to a $16.6 million loss in the corresponding period last year. Operating expenses decreased 14% year-over-year to $16.1 million, driven by lower salary, benefits, stock-based compensation and facilities costs. The company held $143.4 million in cash, cash equivalents and investments as of 31 March 2026. During the quarter, Nautilus initiated its Iterative Mapping Early Access Programme with Baylor College of Medicine and appointed Amber Faust, a proteomics veteran from Olink Proteomics and SomaLogic, as Vice President of Global Sales. The company is developing its Voyager Platform ahead of commercial launch.

Yahoo Finance
Mar 18th, 2026
Baylor College of Medicine becomes first customer for Nautilus' Voyager proteomics platform

Nautilus Biotechnology has announced Baylor College of Medicine as the first customer of its Iterative Mapping Early Access Program for the Voyager Platform. Through an NIH U01-funded study, Baylor will use Nautilus' single-molecule proteomics technology to develop a computational multi-omics toolkit for cancer research. The project, led by Professors Bing Zhang and Yongchao Dou, aims to identify aberrant protein isoforms that contribute to tumour growth, metastasis, immune evasion and therapeutic resistance. Researchers will combine computational approaches with full-length, isoform-resolved proteomic measurements from the Nautilus Voyager Platform to enable direct comparison of transcriptional and proteomic changes at unprecedented resolution. The collaboration pairs Baylor's multi-omics expertise with Nautilus' validated tau proteoforms assay to advance high-resolution cancer isoform analysis.

Yahoo Finance
Mar 2nd, 2026
Nautilus Biotechnology names Amber Faust as VP of sales to drive Voyager Platform commercialisation

Nautilus Biotechnology has appointed Amber Faust as vice president of sales to lead commercial efforts for its Voyager Platform, which enables single-molecule protein analysis. Faust brings nearly two decades of commercial leadership experience in proteomics from companies including Olink Proteomics, SomaLogic and Waters Corporation. The appointment follows Nautilus's recent platform debut and launch of its Iterative Mapping Early Access Programme. Faust will oversee the commercial launch planned for late 2026, including securing pre-orders and managing instrument installations. The company's first offering, the Nautilus Tau Proteoforms assay, is already being used at the Buck Institute for Research on Aging to map tau proteoform groups for neurodegenerative disease research. Faust will focus on expanding adoption across pharmaceutical, biotechnology, academic, clinical and government sectors.

Nautilus Biotechnology, Inc.
Mar 2nd, 2026
News Release Details

News release details. Nautilus Biotechnology appoints proteomics commercial leader Amber Faust as Vice President of Sales. Mar 02, 2026 Veteran sales leader with proven proteomics and life sciences track record from Olink and SomaLogic joins Nautilus to accelerate commercial progress of its Voyager Platform. SEATTLE, March 02, 2026 (GLOBE NEWSWIRE) - Nautilus Biotechnology, Inc. (NASDAQ: NAUT), a company pioneering single-molecule proteome analysis, today announced the appointment of Amber Faust as Vice President of Sales. Ms. Faust joins Nautilus following the public debut of the Nautilus Voyager(TM) Platform, designed to deliver and scale Iterative Mapping, a method that enables single-molecule analysis of proteins and proteoforms across the proteome. Ms. Faust brings nearly two decades of commercial leadership experience in life sciences, with a focus on advancing adoption of emerging proteomics technologies across pharmaceutical, biotechnology, academic, clinical, and government sectors. She has held roles of increasing responsibility at proteomics companies including Olink Proteomics, SomaLogic, and Waters Corporation. "We are pleased to bring on Amber as our first sales hire to take on a major role in introducing the Nautilus Voyager(TM) Platform to the market," said Sujal Patel, Co-Founder and Chief Executive Officer of Nautilus. "She is a proven, mission-driven commercial leader who is ideally suited to accelerate broad adoption of next-generation omics technologies like our Voyager Platform." Ms. Faust's appointment follows two significant milestones for Nautilus as the company advances towards commercialization: the recent debut of the Voyager Platform and launch of the Iterative Mapping Early Access Program. She will guide the company's work to initiate commercial launch of Voyager in late 2026, including securing pre-orders, managing instrument installations at customer sites, and growing market reach. The Nautilus Tau Proteoforms assay is the company's first offering and is already in active use at the Buck Institute for Research on Aging, where researchers are mapping up to 768 distinct tau proteoform groups to further novel biological understanding of neurodegenerative diseases. "Having worked in the proteomics space for nearly two decades, I have seen the field wrestle with the same fundamental limitations, and what Nautilus is doing at the single-molecule level is a genuine step change," said Ms. Faust, Vice President of Sales at Nautilus. "I'm excited to help scale Nautilus' commercial progress by connecting researchers in pursuit of greater proteomics coverage, detail, and resolution with a platform that can meaningfully expand what's possible in drug development and beyond." Ms. Faust holds a Master of Science in Biomedical Science with a concentration in Immunology and Virology from Hood College and a Bachelor of Science in Biology and Chemistry from Lock Haven University. About the Nautilus Voyager(TM) Platform The Voyager Platform employs Nautilus' proprietary Iterative Mapping approach, which is designed to enable rapid measurement of intact single-molecule proteins and proteoforms. The platform's flow cells are designed to accommodate up to 10 billion intact protein molecules, enabling measurement across an exceptionally wide dynamic range. Iterative Mapping independently probes single protein molecules across tens to hundreds of cycles, recording unique binding patterns for each individual molecule. Machine learning algorithms then convert the resulting probe-binding patterns into confident protein and proteoform identifications. Once analysis is complete, single-molecule counts are made available for download and further visualization. The Voyager instrument is designed for operational simplicity and standard lab benchtop placement, with a guided touchscreen user interface and minimal facility requirements, without need for bespoke gas or fluidic connections. About Nautilus Biotechnology, Inc. With its corporate headquarters in Seattle, Washington and its research and development headquarters in San Carlos, California, Nautilus is a development stage life sciences company working to create Voyager, a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus' mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit www.nautilus.bio. Special Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of federal securities laws. Forward-looking statements in this press release include, but are not limited to, statements regarding Nautilus' expectations with respect to the potential of its platform technology, its future products, their functionality and performance or their applicability in biological research and in potentially enabling new diagnostics and therapies. These statements are based on numerous assumptions concerning the development of Nautilus' products, target markets, and other current and emerging proteomics technologies, and involve substantial risks, uncertainties and other factors that may cause actual results to be materially different from the information expressed or implied by these forward-looking statements. Risks and uncertainties that could materially affect the accuracy of Nautilus' assumptions and its ability to achieve the forward-looking statements set forth in this press release include (without limitation) the following: Nautilus' product platform is not yet commercially available and remains subject to significant scientific and technical development, which is inherently challenging and difficult to predict, particularly with respect to highly novel and complex products such as those being developed by Nautilus. Even if its development efforts are successful, its product platform will require substantial validation of its functionality and utility in life science research. In the course of Nautilus' scientific and technical development and associated product validation and commercialization, Nautilus Biotechnology Inc. may experience material delays as a result of unanticipated events; Nautilus Biotechnology Inc. cannot provide any guarantee or assurance with respect to the outcome of its development, collaboration, and commercialization initiatives or with respect to their associated timelines. For a more detailed description of additional risks and uncertainties facing Nautilus and its development efforts, investors should refer to the information under the caption "Risk Factors" in its Annual Report on Form 10-K filed for the year ended December 31, 2025 and its other filings with the SEC. The forward-looking statements in this press release are as of the date of this press release. Except as otherwise required by applicable law, Nautilus disclaims any duty to update any forward-looking statements. You should, therefore, not rely on these forward-looking statements as representing its views as of any date subsequent to the date of this press release. Disclosure Information Nautilus uses filings with the Securities and Exchange Commission, its website (www.nautilus.bio), press releases, public conference calls, public webcasts, and its social media accounts as means of disclosing material non-public information and for complying with Regulation FD. Therefore, Nautilus encourages investors, the media, and others interested in Nautilus to review the information it makes public in these locations, as such information could be deemed to be material information.

Nautilus Biotechnology, Inc.
Feb 19th, 2026
News Release Details

News release details. Nautilus Biotechnology to participate in the TD Cowen 46th Annual Health Care Conference. Feb 19, 2026 SEATTLE, Feb. 19, 2026 (GLOBE NEWSWIRE) - Nautilus Biotechnology, Inc. (NASDAQ: NAUT; or "Nautilus"), a company pioneering a single-molecule protein analysis platform, today announced the company will be participating in the TD Cowen 46th Annual Health Care Conference. Nautilus' management is scheduled to participate in a fireside chat on Monday, March 2, 2026, at 10:30 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.nautilus.bio. About Nautilus Biotechnology, Inc. With its corporate headquarters in Seattle, Washington and its research and development headquarters in San Carlos, California, Nautilus is a development stage life sciences company working to create a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus' mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit www.nautilus.bio. Media Contact [email protected] Investor Contact [email protected]

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