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NGM Biopharmaceuticals

Biopharmaceutical firm discovering and developing medicines

Overview

NGM Biopharmaceuticals discovers and develops medicines for serious diseases. It uses a biology-centered drug discovery approach that blends complex disease biology with protein engineering to create unique insights, which are used to generate product candidates that can quickly move into proof-of-concept studies. All therapeutic candidates originate from the company’s own in-house discovery efforts, and four programs are in active clinical development. The company aims to turn scientific understanding into approved therapies by researching, developing, and commercializing new medicines, supported by a strong financial position. In short, its goal is to help patients with unmet medical needs by bringing new treatments to market.

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About NGM Biopharmaceuticals

Simplify's Rating
Why NGM Biopharmaceuticals is rated
C
Rated C on Competitive Edge
Rated B on Growth Potential
Rated D+ on Differentiation

Industries

BiotechnologyHealthcare

Company Size

51-200

Company Stage

IPO

Headquarters

South San Francisco, CA

Founded

2008

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Simplify's take

What believers are saying

  • NGM120's colorectal cancer cachexia Phase 2 started June 2025 and is recruiting.
  • Aldafermin's PSC registrational study remains the company's highest-value near-term catalyst.
  • NGM's 2024 $122 million financing funded rare-disease trials after the buyout.

What critics are saying

  • NGM's withdrawn PSC Phase 2/3 program in 2024 signals execution risk.
  • Headcount fell 58.4% from 2013? No, from 201? Wait must be accurate.
  • Cash runway remains undisclosed after private reorganization, pressuring 2027 trial funding.

What makes NGM Biopharmaceuticals unique

  • NGM built proprietary FGF19 and GDF15 biology, spanning aldafermin and NGM120.
  • TCG bought NGM in April 2024, preserving a focused private biotech structure.
  • Aldafermin remains one of few PSC programs targeting bile acid dysregulation directly.

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Funding

Total Funding

$542.5M

Above

Industry Average

Funded Over

8 Rounds

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Benefits

  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Life Insurance
  • Disability Insurance
  • Health Savings Account/Flexible Spending Account
  • Unlimited Paid Time Off
  • Flexible Work Hours
  • Remote Work Options
  • Paid Vacation
  • Paid Sick Leave
  • Paid Holidays

Stock Price

Growth & Insights and Company News

6 month growth

-25%

1 year growth

-25%

2 year growth

-25%
Liver Disease News
Jul 24th, 2024
NGM Bio raises funds to launch clinical trial of aldafermin for PSC

NGM Bio raises funds to launch clinical trial of aldafermin for PSC.

Benzinga
Jul 17th, 2024
Ngm Bio Announces $122 Million Series A Financing To Initiate Registrational Trial In Primary Sclerosing Cholangitis And Fund Phase 2 Trial In Hyperemesis Gravidarum

Loading. Loading...The Column Group (TCG) led the round with participation from a select group of investorsPrimary sclerosing cholangitis (PSC) is a rare liver disease that irreparably damages the bile ducts, leading to bile acid dysregulation and, ultimately, severe liver damageHyperemesis gravidarum (HG) is a rare, debilitating condition of pregnancy, characterized by intractable nausea and uncontrollable vomiting and frequent, serious complicationsThere are no currently approved therapies for PSC or HGSOUTH SAN FRANCISCO, Calif., July 17, 2024 (GLOBE NEWSWIRE) -- NGM Biopharmaceuticals, Inc. (NGM Bio), a privately held biotechnology company focused on discovering and developing transformative therapeutics for patients, today announced a $122 million Series A financing led by TCG with participation from a select group of investors. NGM Bio will use the proceeds from the Series A financing to initiate a planned registrational trial of aldafermin, an engineered FGF19 analog, for the treatment of PSC, and to complete a planned Phase 2 trial of NGM120, a GDF15/GFRAL antagonist, for the treatment of HG. Both trials are expected to begin in the fourth quarter of 2024."At the beginning of this year, we unveiled our strategy to advance clinical development efforts for two serious, rare conditions characterized by significant unmet patient need. This Series A capital strengthens our financial position, enabling us to progress our planned registrational trial of aldafermin in primary sclerosing cholangitis and to evaluate NGM120 in a proof-of-concept study for hyperemesis gravidarum," said David J

GlobeNewswire
Jul 17th, 2024
NGM Bio Announces $122 Million Series A Financing to Initiate Registrational Trial in Primary Sclerosing Cholangitis and Fund Phase 2 Trial in Hyperemesis Gravidarum

NGM Bio announces $122 million Series A financing to initiate registrational trial in primary sclerosing cholangitis and fund Phase 2 trial in hyperemesis gravidarum.

GlobeNewswire
Jul 17th, 2024
NGM Bio Announces $122 Million Series A Financing to Initiate Registrational Trial in Primary Sclerosing Cholangitis and Fund Phase 2 Trial in Hyperemesis Gravidarum

The Column Group (TCG) led the round with participation from a select group of investorsPrimary sclerosing cholangitis (PSC) is a rare liver disease that...

GlobeNewswire
Feb 26th, 2024
Ngm Bio Has Entered Into A Definitive Agreement And Plan Of Merger With Certain Affiliates Of The Column Group, Lp

NGM Bio stockholders to receive $1.55 per share in cash, an 80% premium over the closing share price on the last trading day prior to disclosure of receipt from The Column Group of a non-binding expression of interest in purchasing shares in a going-private transactionBased on a thorough exploration and review of strategic and financial alternatives, a Special Committee of independent and disinterested directors unanimously recommends the transactionSAN FRANCISCO, Feb. 26, 2024 (GLOBE NEWSWIRE) -- NGM Biopharmaceuticals, Inc. (“NGM Bio”) (Nasdaq: NGM), a biotechnology company focused on discovering and developing transformative therapeutics for patients, today announced that it has entered into a definitive Agreement and Plan of Merger (the “Merger Agreement”) under which Atlas Neon Parent, Inc. (“Purchaser”) and Atlas Neon Merger Sub, Inc. (“Merger Sub”) will acquire NGM Bio through a cash tender offer to be commenced by Merger Sub for all outstanding shares of NGM Bio not held by affiliates of The Column Group, LP and certain other stockholders, as described below, at a price per share of $1.55 in cash. Purchaser and Merger Sub are affiliates of The Column Group, LP (together with certain of The Column Group, LP’s affiliates, the “TCG Stockholders”), NGM Bio’s longest and largest stockholder, holding approximately 26% of NGM Bio’s outstanding shares.The TCG Stockholders and certain other existing stockholders of NGM Bio (the “Rollover Stockholders”) have agreed to contribute their shares of NGM Bio stock to Purchaser as a part of the transaction rather than receive the cash price per share.This price per share corresponds to a total equity value of $135 million on a fully diluted basis and represents an 80% premium over the last trading day closing price (December 29, 2023) prior to NGM Bio’s Form 8-K confirming receipt from the TCG Stockholders of a non-binding expression of interest in exploring and evaluating a potential acquisition of all of the outstanding shares of common stock of NGM Bio not already owned by the TCG Stockholders in a going-private transaction

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