NNoetik is an AI-native biotechnology company that develops precision cancer immunotherapies. It uses advanced machine learning to analyze complex tumor-immune interactions and builds foundational, multimodal models of cells and tissues from large-scale human data. This enables the design of immunotherapies tailored to individual patients. The company partners with pharmaceutical companies and healthcare providers, licensing technologies, conducting research collaborations, and selling proprietary therapeutic solutions. Unlike many firms that apply AI to existing processes, Noetik creates AI-driven models to guide drug discovery and therapy development, aiming to push the capabilities of precision medicine beyond what humans can achieve. The overarching goal is to advance cancer treatment by delivering AI-powered, personalized therapies and enabling clients to develop and commercialize these solutions.
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Industries
Company Size
51-200
Company Stage
Series A
Total Funding
$54M
Headquarters
South San Francisco, CA
Founded
2022
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Total Funding
$54M
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Noetik has reached its first milestone in a five-year collaboration with GSK, announced in January 2026. The San Francisco-based AI company successfully delivered and deployed its OCTO-VC model inference and fine-tuning capabilities, meeting GSK's testing criteria. Under the agreement, GSK holds a non-exclusive licence to Noetik's OCTO-VC models for non-small cell lung cancer and colorectal cancer, backed by $50 million in upfront capital and near-term milestone payments. The models are biological foundation models trained on hundreds of millions of spatially resolved human cells. GSK's teams are using OCTO-VC to perform virtual cell experiments, investigate patient stratification, and enrich their data with multimodal predictions. The partnership operates on a subscription-based framework rather than acquiring individual drug candidates.
Bruker expands collaboration with Noetik. Advancing tissue foundational models for translational and therapeutic applications. 26-Feb-2026 Symbolic image AI-generated image Bruker Spatial Biology, a division of Bruker Corporation announced that it will expand its collaboration with Noetik Inc., following their prior study of more than 3500 patient samples with the CosMx(R) Spatial Molecular Imager (SMI). CosMx SMI powers Noetik's pre-training and scaling of bio-foundation models to perform complex genome-wide simulations of human cellular- and tissue-level biology to enable diverse therapeutics applications. "Noetik's multiple spatial AI models, including the Oncology Counterfactual Therapeutics Oracle virtual cell, which can simulate patient biology and inform drug discovery, represent transformative breakthroughs for tackling human disease," said Dr. Mark R. Munch, President of the Bruker NANO Group. To develop self-supervised AI, Noetik leverages the CosMx SMI platform to generate the largest and most biologically complete single-cell and subcellular spatial transcriptomic and multiomic datasets in oncology. Noetik is now further imaging thousands of additional patients with the CosMx whole transcriptome assay to train their world models that learn from human tissue data. "Spatial context is necessary for training foundation models that truly learn human biology. We have demonstrated that our models exhibit clear scaling laws; as we ingest more high-resolution CosMx data, we see a predictable and powerful increase in the models' ability to represent complex biology. We are excited to partner with Bruker to scale toward one billion spatially resolved human cells, spanning the breadth of oncology and beyond," said Ron Alfa, MD, PhD, Co-Founder and CEO of Noetik. This collaboration builds on Bruker's best-in-class spatial biology portfolio, including CosMx SMI, AtoMx(R) SIP, CellScape(TM) XR, GeoMx(R) DSP and PaintScape(TM) platform, which together support high fidelity data generation for discovery and translational research.
Agenus, a clinical-stage immunotherapy company, and Noetik, an AI-focused multimodal biology start-up, have announced a research collaboration to develop predictive biomarkers for Agenus's lead immuno-oncology combination, botensilimab (BOT) and balstilimab (BAL).
Agenus has partnered with San Francisco-based Noetik to develop AI-enabled predictive biomarkers for its lead immunotherapy regimen, botensilimab (BOT) and balstilimab (BAL).
Agenus and Noetik enter collaboration to develop ai-enabled predictive biomarkers for BOT/BAL using foundation models of virtual cell biology.
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Industries
Company Size
51-200
Company Stage
Series A
Total Funding
$54M
Headquarters
South San Francisco, CA
Founded
2022
Find jobs on Simplify and start your career today
Don't see your dream role? Check out thousands of other roles on Simplify.Browse all jobs