Nosis Bio

Nosis Bio

Biotech firm delivering cell-targeted RNA therapeutics

Overview

Nosis Bio develops cell-targeted RNA medicines using its Connexa platform, which combines physics-informed deep learning, generative AI, and high-throughput biochemistry to design Targeted Delivery Vehicles for RNA therapeutics. Connexa builds a receptome atlas of the human proteome and identifies over 2,900 targetable cell-specific receptors to reach diverse tissues while reducing systemic toxicity. The company pursues a wholly owned drug pipeline and collaborates with big pharma to apply its platform to high-value indications. Its goal is to deliver precise, safe, re-dosable RNA therapies to hard-to-reach tissues by expanding targetable cell types and advancing preclinical therapeutics toward clinical use.

About Nosis Bio

Simplify's Rating
Why Nosis Bio is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

AI & Machine Learning

Biotechnology

Healthcare

Company Size

N/A

Company Stage

N/A

Total Funding

N/A

Headquarters

Berkeley, California

Founded

2021

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Simplify's Take

What believers are saying

  • Strategic partnerships with Daiichi Sankyo and Johnson & Johnson exceed $1.5 billion in total value.
  • A development candidate for the lead fibrosis program was nominated in July 2025.
  • Connexa™ validated delivery across seven tissues including brain, enabling neurology therapeutic breakthroughs.

What critics are saying

  • FDA's 2025 AI guidance mandates wet-lab validation, potentially delaying IND submission by 12 months.
  • Daiichi Sankyo may terminate the collaboration in Q2 2026 if no valid fibrosis candidate is delivered.
  • Independent studies show receptor-targeted RNA fails in vivo in non-hepatic tissues, questioning platform efficacy.

What makes Nosis Bio unique

  • Connexa™ combines physics-informed deep learning and generative AI to design cell-targeted RNA therapeutics.
  • The platform maps over 2,900 receptors enabling gene silencing in lungs, heart, kidneys, and CNS.
  • Nosis Bio uniquely targets extrahepatic tissues, overcoming the primary delivery barrier for RNA medicines.

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