Nosis Bio

Nosis Bio

Biotech firm delivering cell-targeted RNA therapeutics

Overview

Nosis Bio develops cell-targeted RNA medicines using its Connexa platform, which combines physics-informed deep learning, generative AI, and high-throughput biochemistry to design Targeted Delivery Vehicles for RNA therapeutics. Connexa builds a receptome atlas of the human proteome and identifies over 2,900 targetable cell-specific receptors to reach diverse tissues while reducing systemic toxicity. The company pursues a wholly owned drug pipeline and collaborates with big pharma to apply its platform to high-value indications. Its goal is to deliver precise, safe, re-dosable RNA therapies to hard-to-reach tissues by expanding targetable cell types and advancing preclinical therapeutics toward clinical use.

About Nosis Bio

Simplify's Rating
Why Nosis Bio is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

AI & Machine Learning

Biotechnology

Healthcare

Company Size

N/A

Company Stage

N/A

Total Funding

N/A

Headquarters

Berkeley, California

Founded

2021

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Simplify's Take

What believers are saying

  • March 24, 2026 Johnson & Johnson expansion broadens commercial validation beyond Daiichi Sankyo.
  • July 31, 2025 fibrosis nomination advances Nosis toward first-in-human trials planned for 2026.
  • CF Foundation support and Bakar Labs access previously reduced burn and de-risked early development.

What critics are saying

  • Nosis Bio has only 15 employees, limiting execution across fibrosis, neurology, and immunology.
  • First clinical readouts are still pending 2026, so platform risk remains unproven in humans.
  • A failed Johnson & Johnson or Daiichi Sankyo program would damage financing and partner credibility.

What makes Nosis Bio unique

  • Connexa mapped 2,900+ receptors, expanding known targetable cell types 50X by 2026.
  • March 24, 2026 Johnson & Johnson collaboration validates Connexa for neurology delivery.
  • July 31, 2025 fibrosis candidate reached IND-enabling studies using cell-targeted gene silencing.

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Company News

Business Wire
Mar 11th, 2025
Nosis Biosciences Announces Research Collaboration and Option Agreement with Daiichi Sankyo to Develop Cell-Targeted RNA Medicines

Nosis Biosciences announces Research Collaboration and Option Agreement with Daiichi Sankyo to develop cell-targeted RNA medicines.

HrTechwire
Mar 11th, 2025
Nosis Biosciences Announces Research Collaboration and Option Agreement with Daiichi Sankyo to Develop Cell-Targeted RNA Medicines

Nosis Biosciences, an AI-driven biotechnology company specializing in RNA therapeutics for challenging cell types, today announced it entered into a Research Collaboration and Option Agreement with Daiichi Sankyo.

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