O

Olema Oncology

Clinical-stage biopharma targeting ER-positive breast cancer

Overview

Olema Oncology develops targeted therapies for women’s cancers, with a focus on ER-positive, HER2-negative breast cancer. Its lead drug, palazestrant (OP-1250), blocks and degrades the estrogen receptor (CERAN/SERD) to slow tumor growth, and a second program targets epigenetics with a KAT6 inhibitor in preclinical stages. The company is conducting a Phase 3 trial of palazestrant in combination with CDK4/6 inhibitors and has a collaboration with Novartis to test palazestrant with ribociclib and everolimus. Its goal is to bring palazestrant to market and advance the KAT6 program to clinical testing, expanding options for women with breast cancer.

Work here?Claim your company

About Olema Oncology

Simplify's Rating
Why Olema Oncology is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

51-200

Company Stage

IPO

Headquarters

San Francisco, CA

Founded

2007

Get referred to Olema Oncology

See people who can refer or advise you

Simplify Jobs

Simplify's take

What believers are saying

  • Completed OPERA-01 enrollment in September 2026 de-risks the flagship palazestrant program.
  • Bayer’s May 2026 darolutamide deal expands OP-3136 beyond breast cancer into prostate cancer.
  • SABCS 2026 posters on palazestrant and OP-3136 keep clinical momentum visible into December.

What critics are saying

  • OPERA-01 now reads out in Q1 2027, pushing any 2028 launch.
  • June 30, 2026 cash was $461.1 million while net loss hit $63.2 million.
  • A failed OPERA-01 or OPERA-02 leaves Olema with no approved product and financing strain.

What makes Olema Oncology unique

  • Palazestrant blocks wild-type and mutant ER, unlike legacy SERDs, in 2026 data.
  • OP-3136 targets KAT6A/B, creating a second endocrine-resistance angle beyond palazestrant.
  • Novartis and Bayer collaborations validate Olema’s combo strategy with ribociclib and darolutamide.

Help us improve and share your feedback! Did you find this helpful?

Funding

Total Funding

$830.2M

Above

Industry Average

Funded Over

7 Rounds

Notable Investors:
Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison Coming Soon

Benefits

  • Health Insurance
  • 401(k) Retirement Plan
  • Remote Work Options
  • Paid Vacation
  • Flexible Work Hours
  • Hybrid Work Options
  • Stock Options
  • Wellness Program
  • Mental Health Support
  • Phone/Internet Stipend
  • Home Office Stipend
  • Professional Development Budget

Stock Price

Company News

GlobeNewswire
Nov 4th, 2026
Olema Oncology to present combination data from the palazestrant and OP-3136 programs at the 2026 San Antonio Breast Cancer Symposium.

Olema Oncology to present combination data from the palazestrant and OP-3136 programs at the 2026 San Antonio Breast Cancer Symposium. November 04, 2026 16:01 ET | Source: Olema Oncology SAN FRANCISCO, Nov. 04, 2026 (GLOBE NEWSWIRE) - Olema Pharmaceuticals, Inc. ("Olema" or "Olema Oncology", Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, today announced it will present clinical data from the Phase 1b/2 study of OP-3136 in combination with fulvestrant, the Phase 1b/2 study of palazestrant in combination with everolimus, and the Phase 1b study of palazestrant in combination with atirmociclib in poster presentations at the San Antonio Breast Cancer Symposium (SABCS) taking place December 8-11 in San Antonio, TX. Poster Presentation Details Title: A phase 1 study of OP-3136, a novel oral selective KAT6A/B inhibitor, as monotherapy and in combination with endocrine therapy (ET) in estrogen receptor-positive (ER+), human epidermal growth factor-2-negative (HER2-) advanced breast cancer (ABC) Abstract Number: 3363 Presentation Number: P1-4-16 Date/Time: Wednesday, December 9, 2026, 12:30 PM - 2:00 PM CT/11:30 AM - 1:00 PM ET Title: Palazestrant (OP-1250) in combination with everolimus, a phase 1b/2 study, in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) advanced or metastatic breast cancer Abstract Number: 813 Presentation Number: P4-13-28 Date/Time: Thursday, December 10, 2026, 5:00 PM - 6:30 PM CT/6:00 PM - 7:30 PM ET Title: Palazestrant (OP-1250) in combination with atirmociclib, a phase 1b study, in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) advanced or metastatic breast cancer Abstract Number: 811 Presentation Number: PS10-11 Date/Time: Friday, December 11, 2026, 7:00 AM - 8:30 AM CT/8:00 AM - 9:30 AM ET Additional information can be found on the SABCS website. A copy of the posters will be made available on the Publications page of Olema's website in alignment with the SABCS 2026 embargo policy. About Olema Oncology Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. Olema is advancing a pipeline of novel therapies by leveraging our deep understanding of endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance. Our lead product candidate, palazestrant (OP-1250), is a proprietary, orally available complete estrogen receptor antagonist (CERAN) and a selective estrogen receptor degrader (SERD), currently in two Phase 3 clinical trials. In addition, Olema is developing OP-3136, a potent lysine acetyltransferase 6 (KAT6) inhibitor, now in a Phase 1 clinical study. Olema is headquartered in San Francisco and has operations in Cambridge, Massachusetts. For more information, please visit www.olema.com. About Palazestrant (OP-1250) Palazestrant (OP-1250) is a novel, orally available small molecule with dual activity as both a complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD). It is currently being investigated in patients with recurrent, locally advanced or metastatic ER-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. In clinical studies, palazestrant completely blocks ER-driven transcriptional activity in both wild-type and mutant forms of metastatic ER+ breast cancer and has demonstrated anti-tumor efficacy along with attractive pharmacokinetics and exposure, favorable tolerability, central nervous system penetration, and combinability with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. Palazestrant has been granted U.S. Food and Drug Administration (FDA) Fast Track designation for the treatment of ER+/HER2- metastatic breast cancer that has progressed following one or more lines of endocrine therapy with at least one line given in combination with a CDK4/6 inhibitor. It is being evaluated as a single agent in the ongoing pivotal Phase 3 clinical trial, OPERA-01, and in combination with ribociclib in the ongoing pivotal Phase 3 clinical trial, OPERA-02. Palazestrant is also being evaluated in multiple Phase 1/2 studies in combination with ribociclib, palbociclib, alpelisib, everolimus, and atirmociclib. About OP-3136 OP-3136 is a novel, orally available small molecule that potently and selectively inhibits lysine acetyltransferase 6 (KAT6), an epigenetic target that is dysregulated in breast and other cancers. In preclinical studies, OP-3136 has demonstrated significant anti-proliferative activity in ER+ breast cancer models and is combinable and synergistic with endocrine therapies including palazestrant and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. The Investigational New Drug (IND) application for OP-3136 was cleared by the U.S. Food and Drug Administration (FDA) in December 2024 and patients are currently enrolling in the Phase 1 clinical study. Forward-Looking Statements Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Words such as "anticipate," "believe," "could," "expect," "goal," "intend," "may," "on track," "potential," "upcoming," "will" and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. These statements include those related to the potential beneficial characteristics including but not limited to safety, tolerability, activity, efficacy and therapeutic effects of palazestrant and OP-3136, alone, or in combination with each other or with other drugs, including everolimus and atirmociclib. These forward-looking statements are subject to risks and uncertainties, including, without limitation, those discussed in the section titled "Risk Factors" in Olema's Quarterly Report on Form 10-Q for the quarter ended June 30, 2026, and future filings and reports that Olema makes from time to time with the U.S. Securities and Exchange Commission. Except as required by law, Olema assumes no obligation to update these forward-looking statements, including in the event that actual results differ materially from those anticipated in the forward-looking statements. Media and Investor Relations Contact Courtney O'Konek Vice President, Corporate Communications Olema Oncology [email protected]

GlobeNewswire
Nov 2nd, 2026
Olema Oncology to participate in upcoming investor conferences.

Olema Oncology to participate in upcoming investor conferences. November 02, 2026 16:30 ET | Source: Olema Oncology SAN FRANCISCO, Nov. 02, 2026 (GLOBE NEWSWIRE) - Olema Pharmaceuticals, Inc. ("Olema" or "Olema Oncology", Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, today announced that the Company will participate in the following upcoming investor conferences: Guggenheim 3rd Annual Healthcare Innovation Conference Date and Time: November 10, 2026 at 10 a.m. ET Format: Fireside Chat Location: Boston, MA Stifel 2026 Healthcare Conference Date and Time: November 11, 2026 at 10:40 a.m. ET Format: Fireside Chat Location: New York, NY UBS Global Biopharma Conference Date and Time: November 17, 2026 at 3:20 p.m. GMT/10:20 a.m. ET Format: Fireside Chat Location: London, England Jefferies Global Healthcare Conference Date and Time: November 18, 2026 at 4 p.m. GMT/11 a.m. ET Format: Fireside Chat Location: London, England Live webcasts and recordings of these presentations will be available, as permitted by the event host, in the Events and Presentations section of Olema's investor relations website at ir.olema.com. About Olema Oncology Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. Olema is advancing a pipeline of novel therapies by leveraging our deep understanding of endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance. Our lead product candidate, palazestrant (OP-1250), is a proprietary, orally available complete estrogen receptor antagonist (CERAN) and a selective estrogen receptor degrader (SERD), currently in two Phase 3 clinical trials. In addition, Olema is developing OP-3136, a potent lysine acetyltransferase 6 (KAT6) inhibitor, now in a Phase 1 clinical study. Olema is headquartered in San Francisco and has operations in Cambridge, Massachusetts. For more information, please visit www.olema.com. Media and Investor Relations Contact Courtney O'Konek Vice President, Corporate Communications Olema Oncology [email protected]

GlobeNewswire
Oct 2nd, 2026
Olema Oncology reports inducement grants under Nasdaq Listing Rule 5635(c)(4).

Olema Oncology reports inducement grants under Nasdaq Listing Rule 5635(c)(4). October 02, 2026 16:30 ET | Source: Olema Oncology SAN FRANCISCO, Oct. 02, 2026 (GLOBE NEWSWIRE) - Olema Pharmaceuticals, Inc. ("Olema" or "Olema Oncology", Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, today announced that the Company granted stock options to six new employees to purchase an aggregate of 235,950 shares of the Company's common stock, effective as of October 1, 2026. These awards were approved by the Compensation Committee of Olema's Board of Directors and granted under the Company's 2022 Inducement Plan as an inducement material to the new employees entering into employment with Olema, in accordance with Nasdaq Listing Rule 5635(c)(4). The stock options vest over four years, with 25 percent vesting on the first anniversary of the vesting commencement date for such employee and the remainder vesting in 36 equal monthly installments over the following three years, subject to the employee being continuously employed by Olema as of such vesting dates. The stock options have a 10-year term and an exercise price of $8.27 per share, equal to the last reported sale price of the Company's common stock as reported by Nasdaq on October 1, 2026. The stock options are subject to the terms of the Olema Pharmaceuticals, Inc., 2022 Inducement Plan. Olema is providing this information in accordance with Nasdaq Listing Rule 5635(c)(4). About Olema Oncology Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. Olema is advancing a pipeline of novel therapies by leveraging our deep understanding of endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance. Our lead product candidate, palazestrant (OP-1250), is a proprietary, orally available complete estrogen receptor antagonist (CERAN) and a selective estrogen receptor degrader (SERD), currently in two Phase 3 clinical trials. In addition, Olema is developing OP-3136, a potent lysine acetyltransferase 6 (KAT6) inhibitor, now in a Phase 1 clinical study. Olema is headquartered in San Francisco and has operations in Cambridge, Massachusetts. For more information, please visit www.olema.com. Media and Investor Relations Contact Courtney O'Konek Vice President, Corporate Communications Olema Oncology [email protected]

Associated Press
Sep 2nd, 2026
Olema Oncology grants CFO 650,000 stock options at $10.56 per share

Olema Oncology granted Jason V. O'Byrne, its new chief financial officer, stock options to purchase 650,000 shares of the company's common stock as an employment inducement award. The grant, effective 1 September 2026, has an exercise price of $10.56 per share, matching Nasdaq's last reported sale price on that date. The options vest over four years, with 25% vesting on 11 August 2027 and the remainder vesting in 36 equal monthly instalments over the following three years, subject to continuous employment. O'Byrne's appointment as CFO became effective 11 August 2026. The award was approved by Olema's Compensation Committee and granted under the company's 2022 Inducement Plan. Olema Oncology is a clinical-stage biopharmaceutical company focused on developing targeted therapies for breast cancer.

Quiver Quantitative
Sep 2nd, 2026
Olema Pharmaceuticals grants inducement stock options to newly appointed CFO Jason V. O'Byrne.

Olema Pharmaceuticals grants inducement stock options to newly appointed CFO Jason V. O'Byrne. Posted: 1 day, 9 hours ago / Sept. 2, 2026 8:40 p.m. UTC Olema Pharmaceuticals appointed Jason V. O'Byrne as CFO, granting him 650,000 stock options effective September 1, 2026. Quiver AI summary. Olema Pharmaceuticals, Inc. has announced the appointment of Jason V. O'Byrne as Chief Financial Officer, effective August 11, 2026. To incentivize his role, the company granted him an employment inducement award that includes stock options to purchase 650,000 shares at an exercise price of $10.56 per share, based on the latest Nasdaq reporting. The stock options will vest over four years, with an initial 25 percent vesting on August 11, 2027, followed by monthly vesting. This grant aligns with Nasdaq regulations and is part of Olema's 2022 Inducement Plan. Olema is focused on developing innovative treatments for breast cancer, including the lead candidate palazestrant, currently in Phase 3 trials, and OP-3136, which is in Phase 1 trials. The company operates out of San Francisco and Cambridge, Massachusetts. Potential positives. * Olema Pharmaceuticals appointed Jason V. O'Byrne as Chief Financial Officer, indicating a strategic move to strengthen the company's financial leadership. * The company granted an employment inducement award of 650,000 stock options to Mr. O'Byrne, demonstrating confidence in his capabilities and aligning his interests with shareholders. * The stock options are set at an exercise price equal to the last reported sale price, encouraging performance that aligns with market expectations. * Olema's ongoing commitment to developing innovative therapies for breast cancer, including their lead product candidate, palazestrant, underlines the company's focus on advancing significant medical solutions. Potential negatives. * Granting a significant stock option package (650,000 shares) to the new CFO may raise concerns among investors regarding the company's compensation practices, especially at a time when the company is still in the clinical stage and may not yet be financially stable. * The substantial vesting period for the stock options (four years) could be viewed negatively, as it may imply the need for long-term incentives to retain leadership amidst ongoing challenges in clinical trials and commercialization efforts. * The mention of the employment inducement award might distract from Olema's clinical updates and progress on drug development, potentially raising concerns about prioritization and resource allocation within the company. Faq. Who is Olema Pharmaceuticals? Olema Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on targeted therapies for breast cancer and beyond. What recent appointment did Olema announce? Olema announced the appointment of Jason V. O'Byrne as Chief Financial Officer effective August 11, 2026. What is the stock option grant for Jason O'Byrne? The stock option grant consists of 650,000 shares with an exercise price of $10.56 per share. How does the stock option vest? The stock options vest over four years, with 25% vesting on August 11, 2027, and the remainder in monthly installments. What are Olema's lead product candidates? Olema's lead product candidates include palazestrant (OP-1250) and OP-3136, targeting endocrine-driven cancers. Disclaimer: This is an AI-generated summary of a press release distributed by GlobeNewswire. The model used to summarize this release may make mistakes. See the full release here. EARLY ACCESS Receive OLMA Data Alerts Real-time alerts on filings, insider trades, and market signals - before everyone else. $OLMA insider trading activity. $OLMA insiders have traded $OLMA stock on the open market 4 times in the past 6 months. Of those trades, 0 have been purchases and 4 have been sales. * SHAWNTE MITCHELL (CHIEF LEGAL OFFICER) has made 0 purchases and 2 sales selling 25,000 shares for an estimated $606,352. * CYRUS HARMON has made 0 purchases and 2 sales selling 25,000 shares for an estimated $291,162. To track insider transactions, check out Quiver Quantitative's insider trading dashboard. You can access data on insider stock transactions through the Quiver Quantitative API insider transaction endpoint. $OLMA hedge fund activity. We have seen 94 institutional investors add shares of $OLMA stock to their portfolio, and 131 decrease their positions in their most recent quarter. Here are some of the largest recent moves: * RA CAPITAL MANAGEMENT, L.P. removed 2,600,000 shares (-100.0%) from their portfolio in Q2 2026, for an estimated $32,526,000 * JENNISON ASSOCIATES LLC removed 1,822,123 shares (-100.0%) from their portfolio in Q2 2026, for an estimated $22,794,758 * FMR LLC added 1,756,217 shares (+16.9%) to their portfolio in Q2 2026, for an estimated $21,970,274 * CORMORANT ASSET MANAGEMENT, LP removed 1,750,000 shares (-44.9%) from their portfolio in Q2 2026, for an estimated $21,892,500 * POLAR CAPITAL HOLDINGS PLC removed 1,602,970 shares (-100.0%) from their portfolio in Q2 2026, for an estimated $20,053,154 * DEEP TRACK CAPITAL, LP added 1,500,000 shares (+inf%) to their portfolio in Q2 2026, for an estimated $18,765,000 * FRANKLIN RESOURCES INC added 1,130,629 shares (+92.8%) to their portfolio in Q2 2026, for an estimated $14,144,168 To track hedge funds' stock portfolios, check out Quiver Quantitative's institutional holdings dashboard. You can access data on hedge funds moves and 13F filings through the Quiver Quantitative API 13F endpoint. $OLMA price targets. Multiple analysts have issued price targets for $OLMA recently. We have seen 6 analysts offer price targets for $OLMA in the last 6 months, with a median target of $39.0. Here are some recent targets: * Brad Canino from Guggenheim set a target price of $35.0 on 05/13/2026 * Dennis Ding from Jefferies set a target price of $40.0 on 03/19/2026 * Richard Law from Goldman Sachs set a target price of $27.0 on 03/18/2026 * Anupam Rama from JP Morgan set a target price of $58.0 on 03/18/2026 * Yigal Nochomovitz from Citigroup set a target price of $62.0 on 03/17/2026 * Emily Bodnar from HC Wainwright & Co. set a target price of $38.0 on 03/09/2026 Full release. SAN FRANCISCO, Sept. 02, 2026 (GLOBE NEWSWIRE) - Olema Pharmaceuticals, Inc. ("Olema" or "Olema Oncology", Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, today announced that, in connection with the appointment of Jason V. O'Byrne as Chief Financial Officer effective August 11, 2026, the Company granted Mr. O'Byrne an employment inducement award consisting of stock options to purchase 650,000 shares of the Company's common stock, with an effective grant date of September 1, 2026 and an exercise price of $10.56 per share, equal to the last reported sale price of the Company's common stock as reported by Nasdaq on September 1, 2026. The award was approved by the Compensation Committee of Olema's Board of Directors and granted under the Company's 2022 Inducement Plan. The stock options vest over four years, with 25 percent vesting on August 11, 2027 and the remainder vesting in 36 equal monthly installments over the following three years, subject to continuous employment as of such vesting dates. Olema is providing this information in accordance with Nasdaq Listing Rule 5635(c)(4). About Olema Oncology Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. Olema is advancing a pipeline of novel therapies by leveraging our deep understanding of endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance. Our lead product candidate, palazestrant (OP-1250), is a proprietary, orally available complete estrogen receptor antagonist (CERAN) and a selective estrogen receptor degrader (SERD), currently in two Phase 3 clinical trials. In addition, Olema is developing OP-3136, a potent lysine acetyltransferase 6 (KAT6) inhibitor, now in a Phase 1 clinical study. Olema is headquartered in San Francisco and has operations in Cambridge, Massachusetts. For more information, please visit www.olema.com. Media and Investor Relations Contact Courtney O'Konek Vice President, Corporate Communications Olema Oncology [email protected]

Recently Posted Jobs

Sign up to get curated job recommendations

Olema Oncology is Hiring for 16 Jobs on Simplify!

Find jobs on Simplify and start your career today

Don't see your dream role? Check out thousands of other roles on Simplify.Browse all jobs