OneOncology

OneOncology

Operates network of community oncology practices

Overview

OneOncology builds a network of US oncology practices by partnering with community clinics to broaden access to advanced cancer care. It supports partner sites by investing in clinical, operational, and technical capabilities and by providing a shared data analytics and technology platform to improve care and efficiency. Local practice leadership stays in place, preserving continuity and local expertise while gaining access to centralized resources. The goal is to improve patient outcomes in community settings and sustain high-quality, locally led oncology services by coordinating care through a data-driven platform.

About OneOncology

Simplify's Rating
Why OneOncology is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

Enterprise Software

Healthcare

Company Size

501-1,000

Company Stage

Acquired

Total Funding

$685M

Headquarters

Nashville, Tennessee

Founded

2018

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Simplify's Take

What believers are saying

  • OneOncology’s August 2026 OpenEvidence deal improves clinician workflow and trial matching immediately.
  • ASCO 2026 visibility and OneR research output reinforce credibility with community oncologists.
  • GenesisCare’s Florida relaunch expands footprint and deepens cross-specialty operating leverage.

What critics are saying

  • Cencora completed control in January-February 2026; integration failure can trigger physician defections.
  • Hospital systems and private equity-backed competitors compress margins by buying local practices.
  • Any CMS, payer, or data-security setback threatens referrals, reporting, and OneOncology’s network economics.

What makes OneOncology unique

  • Physician-led network spans 2,300 providers and 1.5 million patients across 20 states.
  • CMS approved OneOncology’s QCDR again on February 25, 2026, strengthening quality reporting.
  • OpenEvidence integrated August 6, 2026 into workflows, linking evidence, genomic data, and trials.

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Funding

Total Funding

$685M

Above

Industry Average

Funded Over

4 Rounds

Acquisition funding comparison data is currently unavailable. We're working to provide this information soon!
Acquisition Funding Comparison
Coming Soon

Benefits

Remote Work Options

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

0%

2 year growth

0%
HealthTech HotSpot
Aug 6th, 2026
OneOncology and openevidence partner to improve cancer care nationwide.

OneOncology and openevidence partner to improve cancer care nationwide. MIAMI & NASHVILLE, Tenn.-(BUSINESS WIRE)-#Oncology-OpenEvidence, the most widely used AI-powered medical search and clinical decision-support platform, and OneOncology, a physician-led national platform empowering independent medical specialty practices, today announced a partnership to embed OpenEvidence into certain clinical applications used across OneOncology's platform to enable physicians to use OpenEvidence for clinical evidence retrieval, reference and research. The integration is designed to make it easier for physicians at OneOncology partner practices to access OpenEvidence directly within their clinical workflows. Over time, the collaboration is expected to expand to include deeper integration with OneOncology's structured genomic data assets and clinical trials matching systems - further aligning evidence, precision oncology insights, and research opportunities at the point of care. In the United States, more than half of hematology/oncology physicians already use OpenEvidence to help inform their clinical decisions. Community physicians at OneOncology partner practices deliver modern, high-quality care to 1.5 million patients nationwide. More than 50 percent of cancer patients in the United States receive their care in community oncology practices. Community physicians manage hundreds of approved therapies across dozens of tumor types, navigate biomarker-driven treatment algorithms that shift with each new approval, and increasingly offer clinical trials that were once limited to academic centers. "Independent physicians across the OneOncology network treat a wide array of cancers across stages, bringing the latest research and treatment options to patients close to home," said Davey Daniel, MD, OneOncology's Chief Medical Officer. "As physicians who read constantly and stay engaged with emerging science, OpenEvidence will help our partners efficiently access the latest, best-available research and evidence, improving the physician experience and supporting better patient outcomes." "Integrating OpenEvidence directly into my workflow will make it easier to access the information I need at the point of care," said Emily Z. Touloukian, DO, FASCO, President and CEO of Coastal Cancer Center in Myrtle Beach, SC. "Oncology is where the information problem in medicine is most acute: the literature moves fast, treatment decisions are increasingly personalized, and the stakes are as high as they get," said Dr. Travis Zack, Chief Medical Officer of OpenEvidence. "OneOncology's partner practice physicians have built a network that brings clinical trials, leading treatment pathways and physician-led innovation into the community. Building OpenEvidence directly into that workflow means the latest evidence, OneOncology's treatment pathways and relevant trials all converge at the point of care." About OpenEvidence OpenEvidence is the fastest-growing and most widely-used clinical decision support platform and medical search engine among U.S. clinicians. According to independent studies, more American physicians use OpenEvidence than all other AI platforms combined. OpenEvidence is trusted by millions of verified healthcare professionals to make high-stakes clinical decisions at the point of care that are sourced, cited, and grounded in peer-reviewed medical literature. Founded with the mission to organize and expand the world's collective medical knowledge, OpenEvidence is actively used daily, on average, by the majority of physicians in the United States. OpenEvidence is free for all verified U.S. clinicians. Learn more at openevidence.com. About OneOncology OneOncology was founded by community physicians, for community physicians, with the mission of improving the lives of everyone living with cancer and other diseases. Its goal is to enable community medical practices to remain independent and to improve patient access to care in their communities, all at a lower cost than in the hospital setting. OneOncology supports its platform of community medical practices through group purchasing, operational optimization, practice growth, and clinical innovation. Its partner practices comprise approximately 2,300+ providers who care for approximately 1.5 million patients across 20 states. To learn more, visit oneoncology.com.

Yahoo Finance
Feb 4th, 2026
Cencora raises fiscal 2026 guidance after completing OneOncology acquisition

Cencora reported 12% adjusted operating income growth and 9% adjusted diluted EPS growth in its fiscal 2026 first quarter, driven by its US healthcare solutions business. The company raised its full-year guidance to reflect year-over-year adjusted operating income growth of 11.5% to 13.5%. CEO Robert Mauch announced the completion of Cencora's acquisition of the majority remaining equity interest in OneOncology. The deal strengthens Cencora's specialty pharmaceutical leadership and MSO (management services organisation) platform. Cencora's strategy focuses on three priorities: strengthening leadership in specialty pharmaceuticals, partnering with market leaders, and enhancing patient access to pharmaceuticals. The company is leveraging technology and advanced analytics to improve customer experience and operational excellence whilst expanding its pharmaceutical-centric MSO footprint.

Business Wire
Dec 16th, 2025
Cencora Accelerates OneOncology Acquisition, Extending Solutions Offering for Community Oncology

Cencora, Inc. (NYSE: COR) today announced it has entered into a definitive agreement to acquire the majority of the outstanding equity interests that it does...

StockTitan
Dec 15th, 2025
Cencora to acquire OneOncology for $3.6B, raising long-term EPS guidance to 10-14%

Cencora has entered into a definitive agreement to acquire the majority stake it doesn't own in OneOncology, a physician-led oncology management services organisation, from TPG. The transaction values OneOncology's enterprise at $7.4 billion, with Cencora paying approximately $5 billion in total cash consideration, including debt retirement. OneOncology has grown substantially since Cencora's initial investment, attracting leading practices through its physician-led approach. The acquisition will strengthen Cencora's specialty solutions and enhance patient access to pharmaceuticals across communities. The deal is expected to close by the end of Cencora's fiscal 2026 second quarter, subject to regulatory approvals. Cencora plans to fund the transaction through new debt financing and expects the acquisition to be approximately neutral to adjusted diluted EPS in the first twelve months. The company has raised its long-term guidance to reflect OneOncology's expected contribution.

PR Newswire
Oct 8th, 2025
OneOncology Acquires GenesisCare in Florida

OneOncology has expanded in Florida by acquiring GenesisCare and will relaunch as SunState Medical Specialists. The acquisition includes over 100 physicians specializing in urology, oncology, and surgical fields, providing care across Florida. Significant investments are planned to upgrade technology and expand access to advanced clinical services.

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