OneSkin

OneSkin

Biotech skincare company targeting cellular senescence

Overview

OneSkin develops premium skincare products powered by OS-01, a peptide that targets cellular senescence to slow skin aging. OS-01 works by preventing buildup of senescent cells, supporting tissue repair, and boosting collagen and hyaluronic acid markers, with lab tests showing thicker epidermis and reduced biological age in skin models. The company differentiates itself by grounding its products in senotherapy science, validating effects in lab models, and combining a direct-to-consumer, subscription-driven model with Amazon and professional channels. Its goal is to expand internationally, develop new products, and advance clinical studies to further validate OS-01 and extend skin health.

About OneSkin

Simplify's Rating
Why OneSkin is rated
C+
Rated C on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Consumer Goods

Company Size

51-200

Company Stage

Series A

Total Funding

$40M

Headquarters

San Francisco, California

Founded

2016

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Simplify's Take

What believers are saying

  • Subscription sales create recurring revenue and better forecastability.
  • Wholesale expansion with dermatologists and aestheticians broadens trust and distribution.
  • International growth in Canada and the United Kingdom expands addressable demand.

What critics are saying

  • Independent studies may fail to validate OS-01’s age-reversal claims.
  • DTC dependence exposes revenue to rising CAC and subscription churn.
  • Premium pricing leaves OneSkin vulnerable to cheaper anti-aging alternatives.

What makes OneSkin unique

  • OS-01 targets cellular senescence, not surface-level moisturization.
  • OneSkin’s founders are four Brazilian scientists with lab-based skin expertise.
  • Peer-reviewed work in npj Aging supports its biological-age claims.

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Funding

Total Funding

$40M

Above

Industry Average

Funded Over

4 Rounds

Series A funding typically happens when a startup has a product and some customers, and now needs funding to scale. This money is usually used to grow the team, expand marketing, and improve the product. Venture capital firms are frequently the main investors here.
Series A Funding Comparison
Above Average

Industry standards

$15M
$8.2M
Discord
$15M
Canva
$20M
OneSkin
$30M
Kalshi

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Health Savings Account/Flexible Spending Account

401(k) Company Match

Remote Work Options

Home Office Stipend

Wellness Program

Growth & Insights

Headcount

6 month growth

-1%

1 year growth

-1%

2 year growth

0%

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