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Orsini Healthcare is a specialty pharmacy that provides targeted, patient-centered care for people with rare diseases, gene therapies, and complex conditions. Its service model centers on high-touch, therapy-specific care teams that offer personalized support to patients based on their particular treatment. The company runs comprehensive programs that improve medication adherence, uses data analytics, and coordinates customized manufacturer programs. It also provides nationwide nursing coverage for in-home infusion services. Orsini is independent and headquartered in Elk Grove Village, Illinois, with accreditations from ACHC, NABP, and ACHC’s Distinction in Rare Diseases and Orphan Drugs. Through its focused condition list—such as Pompe disease, Duchenne Muscular Dystrophy, MPS, Fabry disease, SMA, HAE, PKU, and other rare disorders—the company aims to make complex therapies easier to access and manage for patients across the United States.
Industries
Company Size
201-500
Company Stage
N/A
Total Funding
N/A
Headquarters
Elk Grove Village, Illinois
Founded
2004
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Life Insurance
Orsini, a specialty pharmacy focused on rare diseases, has been selected as the contracted specialty pharmacy for Gilead's Hepcludex (bulevirtide-gmod), a treatment for chronic hepatitis delta virus infection in adults. The therapy received accelerated FDA approval for patients without cirrhosis or with compensated cirrhosis. Hepatitis delta, a co-infection affecting people with hepatitis B, is the most severe form of viral hepatitis and impacts approximately 40,000 people in the US. Hepcludex is a first-in-class entry inhibitor delivered via subcutaneous injection that demonstrated statistically significant improvement in clinical trials. Orsini, operating since 1987, specialises in rare disease pharmacy solutions and gene therapies, providing distribution, patient services and home infusion services.
Orsini has been selected as the exclusive specialty pharmacy and home infusion partner for Denali Therapeutics' AVLAYAH (tividenofusp alfa-eknm), an FDA-approved enzyme replacement therapy for treating neurologic manifestations of Hunter syndrome in paediatric patients. AVLAYAH is a brain-penetrant therapy designed to break down glycosaminoglycans, sugar molecules that accumulate in patients with mucopolysaccharidosis type II (MPS II), a genetic metabolic condition causing progressive cellular damage affecting physical abilities, organ function and cognitive development. Orsini will provide comprehensive home infusion support, allowing patients to receive therapy at home under healthcare provider supervision. The treatment marks the fifth MPS therapy in Orsini's Neurology Centre of Excellence, which has served MPS patients for over 16 years.
Orsini has been named the single-source specialty pharmacy partner for Glaukos' Epioxa, a novel corneal cross-linking treatment for keratoconus, a rare eye disease that thins the cornea and causes vision distortion. Epioxa, which received FDA approval in October 2025, is an oxygen-enriched topical therapy bioactivated by UV light. Unlike traditional procedures, it does not require removal of the corneal epithelium, reducing pain and streamlining recovery whilst delivering clinical outcomes. Orsini, a specialty pharmacy focused on rare diseases since 1987, has partnered with Glaukos for over five years serving the keratoconus community. The company provides integrated pharmacy solutions including distribution, patient services and home infusion for rare disease treatments.
Orsini has been selected as the exclusive specialty pharmacy and hub services partner for LOARGYS (pegzilarginase-nbln) by Immedica Pharma US Inc. LOARGYS is the first therapy approved to lower arginine in patients aged two years and older with Arginase 1 Deficiency, an ultra-rare metabolic disease affecting approximately 250 people in the US. Through this partnership, Orsini will assist patients, caregivers and healthcare providers with medication access, insurance coverage and financial assistance. The company will also provide third-party logistics services for Immedica. LOARGYS is indicated for treating hyperargininemia in adult and paediatric patients with ARG1-D, used alongside dietary protein restriction. Clinical trials showed hypersensitivity reactions occurred in 13% of treated subjects, with life-threatening reactions possible including anaphylaxis.
ELK GROVE VILLAGE, Ill., April 25, 2025 /PRNewswire/ -- Orsini, a leader in rare disease pharmacy solutions, announced today the launch of ORBIT Track™, an innovative, next-generation portal designed to transform how Orsini connects with biopharma partners. This powerful platform delivers real-time visibility into critical patient case information and streamlined collaboration tools to enhance care for patients living with rare and complex conditions.This launch builds upon the momentum of the 2024 launch of ORBIT (Orsini Rare Business Intelligence Technology). ORBIT Track™ will further strengthen the company's data-first ecosystem, built to improve outcomes for rare disease patients and partners alike.Key features of ORBIT Track™ include:Real-Time Case Visibility: Accelerate patient access to treatment with up-to-the-minute updates on case progress and milestones.Accelerate patient access to treatment with up-to-the-minute updates on case progress and milestones. Smart Collaboration Tools: Share updates and alerts through secure HIPAA-compliant messaging to streamline collaboration between biopharma partners and Orsini.Share updates and alerts through secure HIPAA-compliant messaging to streamline collaboration between biopharma partners and Orsini. Actionable Case Insights: Access comprehensive patient progress updates, benefits information and medical documentation in one centralized location.Access comprehensive patient progress updates, benefits information and medical documentation in one centralized location. Next-Level Data Security: Protect patient information through both role-based access aligned by territory and PHI masking capabilities.Protect patient information through both role-based access aligned by territory and PHI masking capabilities
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Industries
Company Size
201-500
Company Stage
N/A
Total Funding
N/A
Headquarters
Elk Grove Village, Illinois
Founded
2004
Find jobs on Simplify and start your career today