Outpace Bio

Outpace Bio

AI-designed proteins guide engineered cell therapies

Overview

Outpace Bio develops AI-powered protein design to create proteins that program engineered cells for improved cancer therapy. It focuses on solid tumors by designing proteins that guide immune responses, boost potency and persistence, and enhance safety and specificity, enabling cell therapies to better recognize and eliminate cancer in the body. The platform can power any cell type and manufacturing approach, making it a versatile option in biotech. The company aims to cure solid tumors by overcoming tumor immune suppression, increasing cell therapy durability, and improving efficacy and safety across diverse cancer indications.

About Outpace Bio

Simplify's Rating
Why Outpace Bio is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

AI & Machine Learning

Biotechnology

Healthcare

Company Size

51-200

Company Stage

Series B

Total Funding

$199M

Headquarters

Seattle, Washington

Founded

2020

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Simplify's Take

What believers are saying

  • Outpace secured $144M oversubscribed Series B in August 2024 to advance OPB-101 into clinical trials in 2025.
  • OPB-101 achieved complete tumor elimination at doses as low as 50,000 cells in solid tumor models.
  • The lead program OPB-101 and second program OPB-201 are both clinical-stage with dedicated funding for clinical data.

What critics are saying

  • OPB-101 mesothelin CAR-T may fail due to off-tumor toxicity in heart or lung tissue within 12–18 months.
  • OutSmart trIL-12 auto-inactivation failure could trigger systemic IL-12 release and fatal cytokine storm in 18–24 months.
  • Competitor Mekonos may enter clinic 6 months earlier with superior mesothelin TCR therapy, starving OPB-101 of commercial market.

What makes Outpace Bio unique

  • Outpace Bio uses AI-designed proteins to program CAR-T cells for enhanced solid tumor function.
  • The company integrates four proprietary technologies to overcome T-cell exhaustion and reduce therapy toxicity.
  • Outpace’s platform is modular and plug-and-play, applicable across any cell type and manufacturing method.

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Funding

Total Funding

$199M

Above

Industry Average

Funded Over

3 Rounds

Series B funding is typically for startups that have proven their business model and need more funding to expand rapidly—often by entering new markets or adding more products. Investors are usually venture capital firms that specialize in later-stage investments.
Series B Funding Comparison
Above Average

Industry standards

$35M
$45M
Linktree
$65M
Substack
$100M
ClickUp
$144M
Outpace Bio

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Health Savings Account/Flexible Spending Account

Commuter Benefits

Legal Services

401(k) Retirement Plan

401(k) Company Match

Stock Options

Performance Bonus

Paid Holidays

Paid Sick Leave

Parental Leave

Growth & Insights

Headcount

6 month growth

-2%

1 year growth

-1%

2 year growth

-1%

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