Pairwise

Pairwise

Develops gene-edited plant-based foods via CRISPR

Overview

Pairwise focuses on the food and agriculture sector by using gene-editing methods, including CRISPR, to develop plant-based products. Its offerings include traits like pitless cherries and crops with higher yields and better climate adaptability. The company works through its Fulcrum™ platform, which accelerates plant innovation and production systems, enabling field-grown gene-edited varieties to be developed and tested. Revenue comes from selling these gene-edited varieties and products, leveraging exclusive intellectual property and in-house tools to bring developments to market faster than competitors. To date, it has grown gene-edited varieties in four crops in the field and aims to bring the first CRISPR-edited food products to the U.S. market this year. The goal is to improve health and sustainability in the food system, offering healthier and more sustainable options for consumers and value-added solutions for food and agriculture businesses.

About Pairwise

Simplify's Rating
Why Pairwise is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Food & Agriculture

Biotechnology

Company Size

51-200

Company Stage

Series C

Total Funding

$155M

Headquarters

Durham, North Carolina

Founded

2017

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Simplify's Take

What believers are saying

  • February 2026 Wild Bioscience licensing extends Fulcrum into AI-driven climate-resilient row crops.
  • April 2026 Ball Horticultural expands specialty-fruit and ornamental commercialization beyond greens.
  • June 2025 CIMMYT and August 2025 Mars deals validate enterprise demand and non-dilutive revenue.

What critics are saying

  • Pitless cherries remain pre-market in August 2026, delaying major fruit revenue for years.
  • Bayer and Corteva control commercialization leverage, squeezing Pairwise into upstream tollbooth economics.
  • If consumer backlash brands CRISPR as GMO, Pairwise's consumer channel collapses.

What makes Pairwise unique

  • Fulcrum® licenses monetize proprietary CRISPR enzymes, trait libraries, and editing workflow.
  • Pairwise shipped the first U.S. CRISPR food, Conscious Greens, in 2023.
  • Pairwise spans consumer fruit and row-crop partnerships with Bayer, Corteva, Mars, CIMMYT.

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Funding

Total Funding

$155M

Above

Industry Average

Funded Over

3 Rounds

Series C funding is usually for startups that are doing well and are looking for more money to fuel major growth, such as acquiring other companies, expanding into global markets, or launching new product lines. Investors typically include larger venture capital firms and private equity.
Series C Funding Comparison
Below Average

Industry standards

$50M
$40M
Pairwise
$50M
Medium
$62M
SeatGeek
$100M
Oura

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Health Savings Account/Flexible Spending Account

401(k) Company Match

Unlimited Paid Time Off

Growth & Insights and Company News

Headcount

6 month growth

-2%

1 year growth

-3%

2 year growth

-6%
Provisioner Online
Aug 1st, 2026
Gene editing: the next essential tool for agriculture.

Gene editing: the next essential tool for agriculture. August 1, 2026 Agriculture has always evolved through better tools. From selective breeding and artificial insemination to precision nutrition and modern biosecurity, producers have consistently adopted innovations that improve animal health, efficiency and long-term sustainability. Now, gene editing is emerging as the industry's next major advancement - and unlike many tools before it, it's already influencing daily life far beyond the farm. For swine producers awaiting access to PIC's porcine reproductive and respiratory syndrome (PRRS)-resistant pig, that broader context matters. Gene editing is no longer just a concept discussed in labs. It's already being used to improve food production systems, reshape the grocery aisle and deliver transformational therapies for devastating diseases like cancer. Improving food production efficiency and quality. "Five or 10 years ago, having gene-edited food products on shelves was more of a vision," says Ryan Bartlett, PhD, Chief Technology and Commercial Officer at Pairwise. "Today, these products are being produced and are on grocery store shelves." Pairwise, an agricultural technology company focused on CRISPR gene editing applications in plants, partners with organizations including Bayer, Corteva and Sun World to improve production efficiency in row crops and consumer-facing foods. The vision is simple: use gene editing to solve practical problems faster than traditional breeding alone can. "Traditional breeding could potentially get us there one day, but it may take 50 years," says Bartlett. "Gene editing allows us to make meaningful improvements on a much faster timeline. And time is the limiting factor in everything we do as farmers." That accelerated timeline matters in agriculture, where producers face constant pressure to improve efficiency, sustainability and food quality. One example is the seedless blackberry, which Pairwise helped develop after consumers repeatedly shared the same frustration: they loved the fruit's flavor and nutritional value but disliked the seeds. "Convenience drives consumption," says Bartlett. "Now families can give their kids a nutritious choice without the nuisance of seeds." The same technology is also being used to address global food system challenges. Pairwise is also working to develop more compact yam varieties for use in African production systems, where improved efficiency could help address nutritional deficits in regions where yams are a staple. Transforming human healthcare outcomes. Outside of agriculture, gene editing is transforming human medicine. "In the U.S., patients now have access to approved gene therapies that treat inherited diseases, including certain forms of blindness, hemophilia and several types of blood cancer," says Rachel Haurwitz, Ph.D., President and CEO of Caribou Biosciences. "More recently, we've seen the first CRISPR-based gene-edited cell therapy approved for sickle cell anemia." Caribou Biosciences, Inc., founded by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, is using gene editing technology to develop therapies for blood cancer. Caribou's own gene-edited CAR-T cell therapies are showing promising results in patients who had exhausted other treatment options, with some patients remaining cancer-free years after a single treatment. For Haurwitz, those outcomes reinforce the broader potential of gene editing across industries. "This is not a single-use technology," she says. "It is a platform that can address challenges across human health, animal health, agriculture and many other fields." Tackling the swine industry's challenge: PRRS. For swine producers, one of those challenges is PRRS. Traditional biosecurity, vaccination and management strategies remain essential, but PRRS continues to pose a threat due to its ability to mutate and spread aggressively. Haurwitz sees PIC's work as an example of gene editing solving a highly targeted, real-world problem. "By making a specific change to a gene involved in how the PRRS virus enters cells, PIC has created pigs that are resistant to the disease without introducing foreign DNA," she says. "That kind of precise, intentional change is exactly what makes CRISPR genome editing so powerful." Industry leaders believe gene editing will ultimately become another practical tool within agriculture - not a replacement for good management or breeding practices. In addition to solving operational problems for producers, gene editing represents an opportunity to meet consumer demands at the same time. The technology is a pathway for achieving reductions in antibiotic use, improved convenience, increased sustainability, enhanced nutrition and more - features that consumers are increasingly seeking out and endorsing with their purchase decisions. With gene editing and gene therapies also leading to monumental solutions for devastating human diseases, consumers are growing increasingly familiar with gene editing and the benefits it can provide. "I think gene editing is going to become an integrated platform across all segments of agriculture," says Bartlett. "If we do this right, it's going to be pretty seamless." The future of gene editing does not represent a technological revolution, but rather a continuation of the promise producers have always made: adopting better tools to care for animals, improve productivity and build a more sustainable future.

Pulse
Apr 22nd, 2026
Pairwise partners with ball horticultural company for ornamental crop gene editing.

Pairwise partners with ball horticultural company for ornamental crop gene editing. - April 22, 2026 Why it matters. By merging Pairwise's precision-editing technology with Wild Bio's AI-based trait discovery, the deal could dramatically shorten breeding cycles and unlock new revenue streams in climate-smart agriculture, a rapidly expanding market segment. Key takeaways. * - Pairwise licenses Fulcrum tools to Wild Bioscience for crop editing * - Wild Bio integrates CRISPR with AI to accelerate trait discovery * - Collaboration targets climate-resilient row crops and carbon-sequestering varieties * - Fulcrum platform includes proprietary enzymes and trait libraries for commercial use Pulse analysis. The agricultural biotech sector is witnessing a surge in strategic licensing deals as companies seek to combine cutting-edge genome-editing with data-driven breeding. Pairwise's Fulcrum(R) platform, built on proprietary CRISPR enzymes and curated trait libraries, represents a next-generation toolkit that can be deployed across multiple commodity crops. By granting Wild Bioscience access, Pairwise not only monetizes its R&D assets but also positions itself as a critical enabler for firms aiming to accelerate trait validation without building in-house editing capabilities. Wild Bioscience's core advantage lies in its AI-powered pipeline that mines genomic and phenotypic data to predict high-impact traits. Integrating Fulcrum's precise editing suite allows the company to move from computational insight to field-ready varieties in a fraction of the traditional timeline. This synergy reduces the breeding cycle from years to months, enabling rapid response to emerging climate threats and consumer demand for sustainable produce. The partnership exemplifies how biotech firms are leveraging artificial intelligence to make gene editing more predictive and cost-effective. From a market perspective, the collaboration targets the growing demand for climate-adapted crops that can sustain yields under drought, heat and salinity stress while also contributing to carbon sequestration goals. Analysts project that climate-smart agriculture could command a multi-billion-dollar market by the early 2030s, and early movers like Pairwise and Wild Bio stand to capture significant share. Their joint effort may also spur further consolidation, as larger agribusinesses look to acquire or partner with firms that combine robust editing platforms with sophisticated AI analytics, reshaping the competitive landscape of modern plant breeding. Madison Hong * Pairwise signed a licensing agreement granting Wild Bioscience access to its Fulcrum(R) genome editing tools. * Wild Bio will integrate CRISPR-based tools into its AI-driven crop trait development pipeline. * The collaboration targets resilient crops designed for climate adaptation, yield improvement, and carbon removal. * The license applies to a range of row crops across Wild Bio's development programs. * Fulcrum(R) includes proprietary gene-editing tools, enzymes, and trait libraries for research and commercial use. Pairwise grants Wild Bioscience access to Fulcrum(R) platform. Pairwise, an agricultural biotechnology company focused on precision breeding, has announced a licensing agreement with Wild Bioscience Ltd. (Wild Bio). The agreement provides Wild Bio with access to Pairwise's Fulcrum(R) genome editing tools for use in crop-trait research and commercial development. Under the terms of the agreement, Wild Bio will incorporate Fulcrum(R) tools into its research and development pipeline to support the design and development of more resilient crop varieties. The license covers both research and commercial applications across a range of row crops. Integrating ai-driven discovery with crispr-based editing. Wild Bio applies artificial intelligence and evolutionary biology to identify beneficial plant traits. By combining computational discovery with commercial genetics, the company aims to accelerate crop improvement programs. Want to join the conversation?

Philadelphia Society for Promoting Agriculture
Mar 4th, 2026
A basket of new fruit varieties is coming your way.

A basket of new fruit varieties is coming your way. Thank gene editing. March 4, 2026 "YOU DON'T notice the seeds in a blackberry until you've tried a seedless one," says Tom Adams, the boss of Pairwise, a biotech company in North Carolina that is working on the first iteration of such a fruit. Gene-edited blackberries are not technically without seeds. Rather, as with seedless grapes, those seeds are so small and soft as to be unnoticeable. Late last year Pairwise announced a joint venture with a fruit-breeding company to develop stoneless cherries, following the success of conventionally bred seedless grapes, watermelons and easy-peel mandarins. It is only a matter of time until more challenging fruits are similarly eviscerated. Over thousands of years of domestication, humans have moulded fruit to their liking. Today's peaches are 16 times the size of their ancient ancestors. The 1,200 varieties of watermelon bear little resemblance to the pale and pip-filled gourd that preceded them. Cultivated fruits also tend to be sweeter. (So much so that some zoos have stopped feeding them to animals.) Some modern fruits, however, achieve their sweetness by lowering acidity and bitterness rather than piling in extra sugar. As Pairwise's blackberries and cherries show, advances in gene editing are allowing fruits to be altered in new ways. CRISPR, the most popular such technique at the moment, and the one employed by Pairwise, permits the deletion of single genes. That enables changes which would be hard to achieve through conventional breeding. Moreover, unlike existing genetically modified crops, those made usingCRISPR do not require DNA from a foreign organism to be inserted - a practice that experience shows puts customers off. Artificial intelligence is helping scientists design fruit more efficiently. The predictive capabilities of computational modelling and machine learning allow them to discover more quickly how multiple genes and biochemical pathways, as well as environmental factors, will come together to produce more complex traits, such as the chemicals that generate flavour. They can make fruits more appealing in other ways, too. For instance, GreenVenus, a Californian firm, is using CRISPR to develop non-browning avocados by obstructing an enzyme called polyphenol oxidase. Scientists have also developed mushrooms and potatoes that oxidise more slowly. So far, few CRISPR-edited fruits have hit the market, because of the time it takes to develop a new generation of fruits from an altered seed, says Ma Hong, a professor of biology at Penn State University in America. It can take several years for apple or peach trees to begin bearing fruit. As a result, the technology is most advanced for tomatoes and strawberries, crops in which the process takes only a few months. In 2021 a Japanese tomato with a higher content of gamma-aminobutyric acid (GABA), a beneficial nutrient, was the first CRISPR food to go on sale. In 2024 scientists in China used the same technology to make tomatoes up to 30% sweeter by disabling genes that limit sugar production. As more fruity creations go on sale, companies believe that more people will eat fruit. Americans have taken a particular liking to berries: according to the USDA Economic Research Service, fresh blueberry imports grew ten-fold between 2000 and 2020. Pairwise estimates that the introduction of its seedless blackberries and stoneless cherries could have a similar effect to seedless easy-peel mandarins, which increased the value of the entire citrus market in America by roughly a third in the four years from 2012, when the fruit became available to consumers year-round. Clearer regulation will help even more. In 2016 Argentina was the first country to rule that gene-edited products should be regulated in the same manner as conventionally bred ones, and many others have taken similar approaches. The European Union's Parliament and Council, the bloc's governing body, reached a provisional deal in December to "simplify" the process for marketing plants bred through new genomic techniques, such as by scrapping the need to label them any differently from conventional ones. That seems an appropriately fruitful approach.

Food Business News
Aug 8th, 2025
Mars enlists biotech to develop more resilient cocoa

- Chocolate, candy and snacks giant Mars Inc. has partnered with biotechnology firm Pairwise to develop more climate-resilient cocoa crops.

Krishak Jagat
Jun 13th, 2025
Pairwise Licenses Gene Editing Tools to CIMMYT to Fast-Track Smallholder Farming Systems' Transformation

13 June 2025, Mexico: Pairwise has entered a landmark licensing agreement with the non-profit, international agricultural research organization CIMMYT to provide access to its Fulcrum(TM) gene editing platform, including the advanced SHARC(TM) CRISPR enzyme.

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