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Pathos

AI-powered platform for oncology drug development

Overview

Pathos combines artificial intelligence with oncology to speed up cancer drug development. It analyzes large oncology datasets, including genomics, using advanced AI and machine learning to identify novel therapeutic targets and biomarkers, guiding the creation of more effective, personalized cancer treatments. The company collaborates with pharmaceutical and biotechnology partners to de-risk pipelines, shorten development timelines, and increase the odds of success for new cancer therapies. Pathos differentiates itself by offering an integrated data-driven platform that leverages diverse genomic and clinical data to drive target validation and biomarker discovery for partner programs. Its goal is to accelerate the delivery of better cancer treatments by turning complex data into actionable insights.

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About Pathos

Simplify's Rating
Why Pathos is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & AnalyticsAI & Machine LearningBiotechnologyHealthcare

Company Size

51-200

Company Stage

Series D

Total Funding

$447M

Headquarters

Chicago, IL

Founded

2022

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What believers are saying

  • Bristol Myers led Pathos's $237 million Series E at roughly $3 billion valuation.
  • Tempus signed a five-year, $55 million dataset deal supporting Foundry through 2031.
  • JSKN016 is heading toward registrational studies, creating a near-term clinical catalyst.

What critics are saying

  • Eric Schadt left on August 21, 2026, weakening Pathos's scientific credibility.
  • Tempus builds Pathos's neuroscience dataset; delays there directly slow Foundry's expansion.
  • JSKN016 or AZD4241 failures would expose Foundry as expensive software, not biotech alpha.

What makes Pathos unique

  • Foundry uses oncology foundation models to pick assets, design trials, and monitor execution.
  • Bristol Myers Squibb leads Pathos's $237 million Series E on October 23, 2026.
  • Pathos controls three clinical assets, including JSKN016, AZD4241, and pocenbrodib.

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Funding

Total Funding

$447M

Above

Industry Average

Funded Over

3 Rounds

Series D funding is typically for companies that are already well-established but need more funding to continue their growth. This round is often used to stabilize the company or prepare for an IPO.
Series D Funding Comparison
Above Average

Industry standards

$77M
$70M
$80M
$100M
$365M

Benefits

  • Hybrid Work Options
  • Remote Work Options
  • 401(k) Retirement Plan
  • 401(k) Company Match
  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Paid Vacation
  • Paid Holidays
  • Wellness Program
  • Mental Health Support
  • Conference Attendance Budget

Growth & Insights and Company News

6 month growth

0%

1 year growth

-3%

2 year growth

2%
Health IT Answers
Oct 29th, 2026
Health IT business news, financial edition - october 29, 2026.

Health IT business news, financial edition - october 29, 2026. DirectTrust and GLEIF Partner on Verifiable Organizational Identity for Healthcare DirectTrust and the Global Legal Entity Identifier Foundation announced a partnership to develop a Qualification Agent model supporting adoption of verifiable Legal Entity Identifiers in U.S. healthcare. The initiative would enable qualified organizations to help establish and verify digital organizational identities, supporting trusted electronic transactions and healthcare information exchange. Vera Health Raises $32 Million for clinical AI search platform Vera Health announced a $28.5 million Series A led by Threshold Ventures, with participation from Mantis VC and SV Angel. Existing investors Y Combinator and Gradient tripled down, bringing the company's total funding to $32 million. The company will use the funds to expand its clinical AI platform and build partnerships with medical societies, publishers and health systems. Southwest General Expands its Partnership with Oracle Oracle announced that Southwest General Health Center in Ohio is expanding its technology relationship to include Oracle Health Patient Accounting, Oracle Health Data Intelligence and Oracle Fusion Cloud Applications. The expansion builds on Southwest General's existing Oracle Health electronic health record and AI documentation capabilities and will integrate clinical, revenue cycle, financial and operational information across the organization. The Springs Living and PointClickCare Announce Technology Co-Development Partnership The Springs Living and PointClickCare announced a strategic partnership to develop technology connecting senior living communities with healthcare services. The agreement will involve PointClickCare working with frontline teams at several Springs Living communities in Oregon to design, test and implement technology supporting resident care and staff workflows. Hackensack Meridian Health Commits $30M to Epic Implementation as Part of Hunterdon Health Merger Hackensack Meridian Health and Hunterdon Health announced a definitive agreement for Hunterdon Health to join the Hackensack Meridian network. As part of the proposed merger, Hackensack Meridian will invest $200 million in facilities, programs and expanded access to care, along with $30 million to implement the Epic electronic health record across Hunterdon Medical Center, ambulatory locations, affiliated practices and participating independent physicians. The transaction remains subject to regulatory approval. Mergers and acquisitions. Austco Healthcare to Acquire RTM Solutions and CareTech Systems Austco Healthcare announced agreements to acquire RTM Solutions, a provider of real-time monitoring and systems-integration software for healthcare facilities, and CareTech Systems, a developer of nurse call technology. Contract announcements. Pathos AI Signs $55M Data Agreement With Tempus AI, Expands Collaboration With Bristol Myers Squibb Pathos AI announced strategic collaborations with Bristol Myers Squibb and Tempus AI to advance AI-driven drug development for Alzheimer's disease and other neurological conditions. Under a five-year, $55 million agreement, Tempus will develop a de-identified longitudinal dataset covering hundreds of thousands of patients with neurological conditions for use by Pathos. Bristol Myers Squibb will gain access to Pathos' Foundry AI platform, including exclusive rights for neuroscience development programs over three years. St. Luke's Health System Selects hellocare.ai for Enterprise Virtual Care Deployment hellocare.ai announced that St. Luke's Health System selected its AI-assisted virtual care platform for deployment across hospitals and inpatient facilities in southern Idaho. The agreement includes virtual nursing, virtual patient observation, telehealth and AI-supported care coordination capabilities. PacBio and Verily Health Announce Multiyear Collaboration for Biomedical AI PacBio and Verily Health announced a multiyear strategic collaboration to integrate PacBio's HiFi sequencing technology with Verily's healthcare data and AI platform. The agreement will connect genomic sequencing workflows with clinical data to create datasets for biomedical research, AI model development and precision medicine applications. Healthcare Triangle Subsidiary Secures Multiyear Health IT Contracts Healthcare Triangle announced that its Purpose Health subsidiary signed several multiyear agreements, including a master services agreement with a university health system for electronic health record optimization and cybersecurity services. The company also secured an agreement to provide IT services supporting a healthcare business unit's global technology center and reported additional advisory work involving MEDITECH and rural health transformation initiatives. Oracle and AstraZeneca Announce AI Collaboration for Clinical Research Oracle and AstraZeneca announced a nonbinding agreement to explore applications of AI, cloud technology and real-world data in clinical research. The companies plan to evaluate tools for identifying clinical trial participants, improving evidence generation and connecting research insights with clinical workflows. Initial work will focus on hypertension care and clinical research in Abu Dhabi, with additional projects under consideration. Venture capitol and funding. Kivo Health Raises $10M in Series A At-home virtual care provider Kivo Health raised $10 million in Series A funding, to scale AI-powered care for seniors with chronic disease. Sunlight AI Raises $17.4M in Seed Funding to Support Independent Medical Practices Sunlight AI announced its launch and $17.4 million in seed funding to develop an AI-enabled operating platform for independent medical practices. The round was led by Lan Xuezhao, founder of Basis Set Ventures, with participation from Sofeon Ventures, Social Leverage, Actions Capital, Overlook Ventures and Early Light Ventures. The company also announced its acquisition of Bradford Medical Associates as part of its strategy to provide administrative, financial and operational support to independent physicians. XRlabs Raises $8.4M in Seed Funding for AI-Powered Surgical Platform XRlabs announced $8.4 million in seed funding led by Playground Global, with participation from Eka Ventures. The financing will support development and clinical deployment of the company's AI powered surgical platform, which combines live surgical video, navigation data and patient imaging to provide real-time information during procedures. XRlabs also announced that former Medtronic Chairman and CEO Omar Ishrak has joined its board as chair. Pathos AI Raises $237M Series E at $3B Valuation Pathos AI announced a $237 million Series E financing round led by Bristol Myers Squibb, with participation from existing investors. The round values the AI-driven drug development company at approximately $3 billion. The funding will support expansion of its Foundry AI platform and clinical development of its oncology pipeline. Baba Raises $40M Series A to Expand AI-Enabled Medicare Care Coordination Baba, an AI-enabled care coordination company serving Medicare and Medicaid populations, announced a $40 million Series A led by FirstMark Capital, with participation from CVS Health Ventures, Valtruis, General Catalyst, Genius Ventures and Ground Up Ventures. The funding will support expansion of the company's clinical care teams, AI research and partnerships with health plans, as well as its value-based care arrangements. Making the cut, milestones, accolades, awards and more. Hackensack Meridian Health Commits $30M to Epic Implementation as Part of Hunterdon Health Merger Hackensack Meridian Health and Hunterdon Health announced a definitive agreement for Hunterdon Health to join the Hackensack Meridian network. As part of the proposed merger, Hackensack Meridian will invest $200 million in facilities, programs and expanded access to care, along with $30 million to implement the Epic electronic health record across Hunterdon Medical Center, ambulatory locations, affiliated practices and participating independent physicians. The transaction remains subject to regulatory approval.

Alpha Movement LLC
Oct 23rd, 2026
Key points.

Key points. * Bristol Myers leads Pathos AI's new funding round * Tempus AI to build Pathos a neurology dataset * What Bristol Myers gets from Pathos's Foundry platform Pathos AI announced partnerships with Bristol Myers Squibb (BMY) and Tempus AI (TEM) on Friday to develop AI tools and a patient dataset for research into Alzheimer's and other neurological diseases. Bristol Myers also led Pathos's Series E funding round, which raised $237 million and valued the New York-based company at about $3 billion. "Neurological diseases demand more than any one company can bring on its own," Pathos chief executive Iker Huerga said in the company's release. Bristol Myers also gets access to Pathos's AI platform for its drug research. Tempus shares rose about 6% on Friday, while Bristol Myers shares fell about 2.4%. Pathos is privately held. Tempus will build the dataset. Under a five-year, $55 million agreement, Pathos will license a de-identified dataset that Tempus plans to build from "hundreds of thousands of patients with neurological conditions." De-identified means names and other details that could identify a patient are removed. The release says the data is designed to track outcomes over time. Tempus will apply the infrastructure and expertise it has built in oncology to create the dataset, according to the release. The companies gave no date for when it will be ready. Pathos will run the data through Foundry, its AI platform, to "generate and test hypotheses on disease biology" and to inform the design of "more targeted, adaptive clinical trials." Pathos built that approach in cancer drug development, where the release says it guides decisions across the company's clinical-stage pipeline. "Making meaningful progress against a disease as devastating as Alzheimer's requires unprecedented data scale and computing power," said Eric Lefkofsky, Tempus's founder and chief executive. Bristol Myers gets access to Foundry. Bristol Myers gets non-exclusive access to Foundry across its broader research and development portfolio. It also gets what the release calls "three-year exclusive rights to support its neuroscience development programs." The release doesn't say whether those rights bar other companies from using Foundry for neuroscience work. The drugmaker aims to "identify patients most likely to benefit from potential therapies and design more precise clinical trials," according to the release. "Our investment in Pathos reflects our commitment to applying advanced AI and data science across research and development to accelerate innovation for patients," said Simon Davies, senior vice president and head of data and quantitative sciences at Bristol Myers. The release doesn't say how much of the Series E Bristol Myers put in or what it pays for the platform access. It also names no specific Bristol Myers drug program the platform will support. Pathos plans to spend on Foundry and cancer drugs. Pathos plans to use the new money to scale Foundry and advance its pipeline, including the experimental cancer drug JSKN016 and a breast cancer drug partnered with AstraZeneca, Reuters reported. The company's clinical-stage programs cover prostate cancer, multiple myeloma, lung cancer, breast cancer, and other solid tumors. "Intelligence alone does not bring a therapy to market," Huerga said. The AIStockWire daily brief Top movers, notable insider buys and fresh Congress trades in your inbox each morning. Free. No spam, ever. Unsubscribe in one click.

DealForma
Oct 23rd, 2026
Cancer R&D Partnerships, M&A, Venture Funding and IPO Activity - Q3 2026 review.

Cancer R&D Partnerships, M&A, Venture Funding and IPO Activity - Q3 2026 review. * By Ani Harutyunyan * Oct 23, 2026 Cancer deal value slumped in Q3 2026, but radiopharmaceuticals and AI anchored the standout deals. Value fell faster than volume in partnerships, M&A and IPOs, while venture capital held nearly steady across fewer rounds. Partnerships held at 50 deals, but value dropped 60.0% to $16.7B and upfronts 44.8% to $1.6B. Alphamab licensed Phase 3 TROP2/HER3 bispecific ADC JSKN-016 to Pathos AI for $125M upfront and up to $2.1B in milestones. Merck took rights to SciBrunch's preclinical oral KRAS G12D molecular glue SPR-2015 for $400M upfront and up to $1.7B more. M&A nearly halved to 17 deals, and value including contingents fell 67.9% to $15.6B. Yet the median upfront jumped 185.7% to $1.1B. Curium will take radiopharmaceutical maker Lantheus private at $102.50 per share, up to approximately $8.0B with its CVR. Telix will acquire ITM for $1.7B upfront plus up to $700M in milestones, adding Phase 3 neuroendocrine tumor asset ITM-11. Venture rounds fell 29.0% to 44, while capital slipped just 3.2% to $3.0B. Chai Discovery raised a $400M series C at a $3.8B valuation for AI-driven molecular design. AdvanCell's oversubscribed $315M series D backs ADVC001, a Phase 2 Lead-212 alpha therapy for metastatic prostate cancer. IPOs fell to 1 from 3, and proceeds dropped 86.9% to $150M, excluding a partial option exercise. The lone listing, BlossomHill Therapeutics, priced at $16.00 per share to advance EGFR-mutant lung cancer candidate BH-30643. Cancer R&D Partnerships Cancer R&D partnership activity held steady in Q3 2026 at 50 deals, a slight 2.0% dip from 51 in Q2. Total deal value, however, contracted sharply, falling 60.0% to $16.7B from $41.8B. Upfront cash and equity also weakened, with the total down 44.8% to $1.6B from $2.9B. In contrast, average upfront cash and equity jumped 150.0% to $50M from $20M. The median upfront moved the other way, dropping 28.9% to $113M from $159M. Overall, the pullback was in value rather than volume, with total deal value and upfront funding both well below Q2. Prominent Cancer R&D Partnerships - Q3 2026 Alphamab Oncology's subsidiary Alphamab Biopharmaceuticals licensed JSKN016 to Pathos AI for $125M upfront and up to $2.1B in milestones. Tiered royalties run from high single digits to low double digits. JSKN016 is a TROP2/HER3 bispecific ADC for solid tumors, in Phase 3 for triple-negative breast cancer. Pathos gains exclusive rights outside the Chinese Mainland, Hong Kong, Macau, and Taiwan, funding all development and commercialization. It will advance JSKN016 with its AI-driven platform and is raising to $300M in a series E. SciBrunch granted Merck exclusive worldwide rights to develop, manufacture, and commercialize SPR-2015. For the preclinical asset, SciBrunch will receive $400M up front and is eligible for up to $1.7B in further payments. These cover development milestones, sales milestones, and other activity payments across multiple indications (breakouts not disclosed). SPR-2015 is an oral molecular glue KRAS G12D (ON) inhibitor. It targets the KRAS G12D mutation in pancreatic, colorectal, lung, and other cancers. Cancer M&A Cancer M&A activity nearly halved in Q3 2026, dropping 46.9% to 17 deals from 32 in Q2. Total M&A value, including contingents, contracted even faster, falling 67.9% to $15.6B from $48.6B. Excluding contingents, total cash value declined 62.7% to $14.4B from $38.6B. In contrast, average upfront cash and equity rose 17.6% to $2.1B from $1.8B. The median upfront surged 185.7% to $1.1B from $385M. Overall, Q3 brought far fewer deals and sharply lower total value than Q2, but larger upfronts per deal. Prominent Cancer M&As in Q3 2026 Curium will take Lantheus private for $102.50 per share in cash plus a non-transferable CVR of up to $12. That totals up to $114.50 per share, or about $8.0B. It represents premiums of 29% and 38% to the unaffected 30-day and 60-day VWAPs. Lantheus' lead radiopharmaceuticals include Pylarify for PSMA-positive prostate cancer detection, Definity for echocardiography, and Neuraceq for Alzheimer's beta-amyloid imaging. The CVR pays up to $8 on 2030 prostate cancer diagnostics sales targets. Neurology diagnostics targets for FY2028 to FY2030 carry up to $3, and 2030 Definity sales above $400M carry $1. The deal pairs Curium's theranostics with Lantheus' U.S. radiodiagnostics across cancer, neurology, and cardiology in more than 70 countries. Closing is expected in the first half of 2027. Telix will acquire ITM Isotope Technologies Munich for $1.7B upfront plus up to $700M in milestones. The upfront includes $1.3B in Telix shares at $11.84, Telix's 30-day trailing VWAP. It also covers $302M of assumed net debt and $96M of management equity rollover and transaction expenses. Lead asset ITM-11 (lutetium-177 edotreotide) completed Phase 3 in G1-G2 gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The FDA issued a complete response letter in August 2026 citing manufacturing, not clinical, issues, and ITM plans to resubmit. ITM also brings approved radiolabeling precursor EndolucinBeta and pipeline assets in glioblastoma, prostate and ovarian cancers, and CAIX-expressing solid tumors. Approval milestones pay $100M in G1-G2 GEP-NETs by end-2027 and $100M in G2-G3 by end-2030. Lung NET approval by end-2031 adds $50M, and ITM-11 net sales above $150M in FY2030 add up to $450M. The combined company expects over $1.3B in 2026 revenue and a positive EBITDA contribution from 2027. Closing is expected by the end of 2026, leaving Telix holders with 76.3% and ITM holders with 23.7%. Cancer Venture Funding Activity Cancer venture funding activity slowed in Q3 2026, falling 29.0% to 44 rounds from 62 in Q2. Total capital raised held up far better, slipping just 3.2% to $3.0B from $3.1B. Overall, the capital deployed was nearly the same as Q2 across fewer rounds. Prominent Cancer Venture Funding Activity in Q3 2026 Chai Discovery raised a $400M series C at a $3.8B valuation, nearly triple its $1.3B December 2025 mark. Index Ventures led, joined by Kleiner Perkins, Sequoia Capital, Dimension, and backers including Thrive Capital and OpenAI. Its AI models predict and reprogram molecular interactions to accelerate preclinical drug discovery. Chai says Chai-2 was the first zero-shot model to reach double-digit experimental success in de novo antibody design. Chai-3 lifts target success rates and binding affinity further. Eli Lilly, Pfizer and Novartis are adopting its models, and Argenx, Bristol Myers Squibb and GSK signed collaborations by October. Proceeds fund compute, data, research, and product development. AdvanCell closed an oversubscribed, upsized $315M series D, led by Ally Bridge Group with Alpha Wave as co-lead. Eli Lilly and Sanofi Ventures returned, and new backers include Bain Capital Life Sciences and Fidelity. Its lead program, ADVC001, a Lead-212 PSMA-targeted alpha therapy, is in Phase 2 for metastatic prostate cancer. The company reports encouraging Phase 1b anti-tumor activity and favorable tolerability, with updated TheraPb data at ESMO 2026. Proceeds will push ADVC001 toward Phase 3 and scale its vertically integrated Lead-212 supply and U.S. manufacturing. Brandon Capital calls it one of the largest private radiopharmaceutical financings globally. Cancer IPO Activity Cancer IPO activity dwindled in Q3 2026, falling 66.7% to 1 IPO from 3 in Q2. Total capital raised fell sharply, down 86.9% to $150M from $1,148M. Overall, Q3 marked a significant step down from Q2 in both IPO activity and fundraising. Prominent Cancer IPO Activity in Q3 2026 BlossomHill Therapeutics raised $150M gross in an upsized Nasdaq IPO (BLSM) of 9,375,000 shares at $16.00. Underwriters later bought 1,141,240 of 1,406,250 option shares, lifting total net proceeds to $152M. Lead asset BH-30643 is a non-covalent, macrocyclic, brain-active, mutant-selective OMNI-EGFR inhibitor in the global Phase 1/2 SOLARA trial. It targets classical, atypical and exon 20 insertion EGFR mutations in non-small cell lung cancer, plus C797S and T790M resistance. C797S appears in about 13% of patients with third-generation TKI resistance, with no approved U.S. oral targeted therapy. The FDA granted Fast Track in August 2026, and a Q4 end-of-Phase 1 meeting will discuss accelerated approval. The pipeline adds Phase 1 CLK inhibitor BH-30236 in relapsed or refractory AML and higher-risk MDS, and preclinical pan-KRAS BH-501284. CEO J. Jean Cui, lead inventor of crizotinib, lorlatinib, and repotrectinib, co-founded Turning Point, later acquired by Bristol Myers Squibb. The company expects cash to last into Q2 2028, past pivotal Phase 2 dosing in Q1 2027 and 2027 readouts.

MarketScreener
Oct 23rd, 2026
Pathos AI partners with Bristol Myers Squibb and Tempus AI to accelerate medical research.

Pathos AI partners with Bristol Myers Squibb and Tempus AI to accelerate medical research. Pathos AI announced a partnership with Bristol Myers Squibb and Tempus AI to harness artificial intelligence in the development of treatments for Alzheimer's disease and other neurological disorders. The collaboration comes with a $237m Series E funding round led by Bristol Myers Squibb, valuing the New York-based company at approximately $3bn. The transaction aims to strengthen Pathos AI's research capabilities and accelerate the identification of new therapeutic avenues through the analysis of large-scale medical data. Published on 10/23/2026 at 10:57 am EDT MarketScreener.com Under the agreement, Tempus AI will build a database covering several hundred thousand patients with neurological diseases, which Pathos AI will be able to access for five years in exchange for $55m. The information will be analyzed by its Pathos Foundry platform to gain a better understanding of the biological mechanisms behind diseases, identify potential treatments and improve the design of clinical trials. Bristol Myers Squibb will receive strategic, nonexclusive access to the technology across all of its research and development activities, as well as exclusive rights for three years to its neuroscience programs. The $237m raised will also enable Pathos AI to develop its platform and advance its pipeline of experimental drugs. The projects involved include JSKN016, an experimental cancer treatment, as well as a breast cancer program being conducted with AstraZeneca. The strategy reflects the company's intention to expand the use of artificial intelligence beyond neurological diseases, particularly in oncology. For the three partners, the goal is to make better use of medical data to accelerate drug discovery and make clinical trials more precise and better suited to patients. (C) MarketScreener.com - 2026

Axios
Oct 23rd, 2026
Pathos AI raises $237M Series E at $3B valuation to advance cancer drugs

Pathos AI, a precision oncology biotech, said on Friday it raised a $237 million Series E round at a $3 billion post-money valuation. The funding gives the company more resources to advance its cancer drugs. It comes amid investor enthusiasm for AI-driven drug development.

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