Overview
Profound Research is a clinical research organization that operates a nationwide network of trial sites, partnering with community physicians to bring pharmaceutical and biotech studies into everyday medical practices. It recruits and enrolls patients from a combined database of more than 1.25 million people, coordinates site operations and investigator oversight, and runs studies across more than 15 therapeutic areas on behalf of trial sponsors. Its network spans 22 sites across four geographies, with over 1,000 providers, 110-plus active investigators, and more than 130 clinical trials conducted to date. What sets Profound Research apart is its model of embedding research infrastructure within existing community practices, giving physicians and their patients access to experimental treatments without leaving their local care setting. The goal is to expand patient access to new treatments while helping sponsors conduct trials through a community-based site network.
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Simplify's Take
What believers are saying
- September 15, 2026 Series D raised $180 million at $1.8 billion valuation.
- June 13, 2026 and March 17, 2026 partnerships expanded Detroit and San Diego reach.
- Homepage claims 1.25 million patients, supporting faster recruitment than standalone sites.
What critics are saying
- Sequoia and Kleiner-backed competitors can outspend Profound after its September 2026 Series D.
- Growth depends on physician partnerships; one failed renewal disrupts enrollment and revenue quickly.
- No disclosed layoff issue exists, but 300+ staff and rapid hiring raise execution risk.
What makes Profound Research unique
- Embedded trial sites inside physician practices across 22 sites and 1,000 providers.
- Detroit and Southern California partnerships give direct access to prescreened patient pools.
- 130+ trials and 110+ investigators create operating leverage for sponsors and employers.
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