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Revolution Medicines

Clinical-stage oncology company developing RAS inhibitors

Overview

Revolution Medicines develops precision oncology drugs focused on cancers driven by RAS mutations. Its RAS(ON) inhibitors are small molecules that bind the active form of RAS to block cancer signaling, with candidates like Daraxonrasib (RMC-6236), Elironrasib (RMC-6291), and Zoldonrasib (RMC-9805) advancing in global Phase 3 trials. The company funds its research through collaborations, royalties, and upfront funding, and has not yet marketed a product. Its goal is to bring effective RAS-targeted therapies to patients and advance multiple candidates through late-stage trials toward approval, supported by strong cash reserves.

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About Revolution Medicines

Simplify's Rating
Why Revolution Medicines is rated
B+
Rated A on Competitive Edge
Rated A on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

1,001-5,000

Company Stage

IPO

Headquarters

Redwood City, CA

Founded

2014

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Simplify's take

What believers are saying

  • Q3 2026 RASONQUE revenue reached $197.6 million in roughly five weeks.
  • More than 5,000 U.S. patients received commercial RASONQUE by September 30, 2026.
  • NCCN guideline adoption and 13.2-month survival support rapid prescriber uptake and pricing power.

What critics are saying

  • Q3 2026 burn hit $407.5 million; 2026 operating expenses stay $2.1-$2.2 billion.
  • RASONQUE's launch included finite bolus from expanded access and channel stocking, then growth normalizes.
  • Phase 3 readouts in 2027 can destroy the stock if first-line or adjuvant trials fail.

What makes Revolution Medicines unique

  • RASONQUE won FDA approval August 26, 2026; first oral RAS(ON) inhibitor launched commercially.
  • Revolution Medicines controls four global Phase 3 programs spanning PDAC, NSCLC, adjuvant, and combinations.
  • BeOne funds RASonate 312, validating Revolution's platform while preserving ex-US commercialization rights.

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Funding

Total Funding

$4.3B

Above

Industry Average

Funded Over

13 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison Coming Soon

Benefits

  • Company Equity

Stock Price

Growth & Insights and Company News

6 month growth

2%

1 year growth

0%

2 year growth

0%
Yahoo Finance
Nov 8th, 2026
Revolution Medicines posts $197.6M in first Rasonque sales as 105 hedge funds back stock

Revolution Medicines (NASDAQ:RVMD) has moved from research-focused biotech to commercial drugmaker after US approval of Rasonque, its treatment for certain patients with metastatic pancreatic cancer. A total of 105 hedge funds back the stock. Rasonque, approved on August 26, generated $197.6 million in net product revenue in the third quarter, after only about five weeks on the market. The company warned that early sales were boosted by patients moving over from an expanded access programme, patients waiting for approval, and initial distribution stocking. Revolution Medicines posted a net loss of $407.5 million, up from $305.2 million a year earlier. Research and development spending rose to $417.1 million from $262.5 million. The company held about $3.7 billion in cash, equivalents, and marketable securities at September 30.

Yahoo Finance
Nov 7th, 2026
Revolution Medicines jumps 8% on Rasonque launch, $198M revenue and $257 fair value estimate

Revolution Medicines shares rose 8.24% in a day after third quarter results and the launch of its cancer drug Rasonque. The company reported revenue of $197.56 million and a net loss of $407.46 million. The stock is up 143.33% year to date and 215.16% over one year, though it is down 4.28% over 30 days and 6.27% over 90 days. The most followed analyst narrative puts fair value at $257.47, against a last close of $192.28, or 25.3% undervalued. A discounted cash flow model from Simply Wall St estimates $1,409.01. Risks include setbacks in late-stage RAS trials and weaker than expected Rasonque uptake. The company has eight ongoing or planned Phase III trials.

Yahoo Finance
Nov 5th, 2026
Revolution Medicines posts $197.6M in first RASONQUE sales as quarterly net loss widens to $407.5M

Revolution Medicines reported $197.6 million in third-quarter net product revenue from RASONQUE, its newly approved pancreatic cancer drug. The figure reflects about five weeks of US sales and more than 5,000 commercial patients. Executives cautioned that early sales included patients moving from an expanded access program and others who had run out of treatment options. Chief global commercialization officer Anthony Mancini said both groups are finite sources of demand, and it is too early to judge the launch's trajectory. The company posted a net loss of $407.5 million, up from $305.2 million a year earlier, as research and commercial spending rose. It ended the quarter with $3.7 billion in cash and marketable securities. The Food and Drug Administration approved the drug on August 26.

Seeking Alpha
Nov 4th, 2026
Revolution Medicines rises on Q3 beats; maintains 2026 guidance.

Revolution Medicines rises on Q3 beats; maintains 2026 guidance. * Revolution Medicines is ~~6% higher in after-hours trading Wednesday after posting Q3 financial results that beat on both lines. * The oncology therapies developer also reaffirmed full-year 2026 GAAP operating expense guidance of $2.1B-$2.2B. * Q3 GAAP EPS of -$1.90 compares to -$1.61 in the year-ago period. * Revolution noted that revenue in the quarter (ended Sept. 30) for Rasonque (daraxonrasib), its second-line therapy for metastatic pancreatic cancer approved in late August, reached $197.6M. * The company ended the quarter with cash, cash equivalents, and marketable securities of ~$3.7B compared to ~$2B on Dec. 31, 2025. Fresh Stock Ideas, Every Day Explore diverse investing perspectives with daily analysis from experts across the market.

PR Newswire
Oct 30th, 2026
Medicilon presents Revolution Medicines with the "Excellence in Client Partnership Award"

Medicilon presents Revolution Medicines with the "Excellence in Client Partnership Award" Oct 30, 2026, 12:00 ET BOSTON, Oct. 30, 2026 /PRNewswire/ - Dr. Yang Liu, Director of Medicinal Chemistry at Revolution Medicines, Inc., and Dr. Kristof Pota, Senior Scientist, visited Medicilon's Nanhui R&D Center. Dr. Maosheng Duan, President of Medicilon's Drug Discovery and Pharmaceutical Research Divisions, Dr. Jian Wang, Vice President of Medicilon, and their team welcomed them. The two parties held in-depth discussions on project progress, data transfer, and strategic priorities for the coming year. During the visit, Medicilon presented Revolution Medicines with the "Excellence in Client Partnership Award," recognizing the substantial clinical value of the company's pioneering pan-KRAS drug discovery and development. The award also honors years of joint effort, mutual trust, and shared success by both R&D teams, setting an outstanding example of bilateral collaboration. A Three-Year Partnership Built on a Trusted R&D Model Over the past three years, Medicilon's FTE team has worked closely with Revolution Medicines to tackle R&D technical challenges, consistently prioritizing client needs and focusing on the single objective of efficiently delivering high-quality molecules. This partnership has established a model of mutual trust and robust CRO-client collaboration. At the award ceremony, Dr. Duan commended Revolution Medicines for its pioneering work in advancing KRAS - a target once deemed "undruggable" - and congratulated the company on the U.S. FDA's August 2026 approval of the NDA for Daraxonrasib for metastatic pancreatic cancer. This milestone offers new hope for pancreatic cancer patients and delivers significant clinical value. The Excellence in Client Partnership Award recognizes the trust, dedication, and achievements of both teams over more than three years of collaboration, reflecting Medicilon's confidence in a deeper, long-term partnership. In-Depth Discussions Explore New Collaboration Opportunities During the discussions, Dr. Wang outlined Medicilon's growth and its integrated R&D platform spanning target discovery to IND submission. Medicilon's quality system meets international standards and holds NMPA, OECD GLP, FDA GLP, and AAALAC accreditation. Its advanced platforms support ADC/AOC, TPD, RIPTAC, RNAi, and peptide programs. Both parties discussed cross-regional data transfer, project management, future collaboration, and ways to enhance cross-border R&D efficiency. Laboratory Tour Subsequently, Drs. Liu and Pota toured Medicilon's R&D laboratories, visiting the chemistry and oligonucleotide labs as well as the API and preclinical research facilities, gaining firsthand insight into Medicilon's R&D infrastructure and quality management system.

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