SamaCare

SamaCare

Optimizes prior authorizations for physician-administered drugs

Overview

SamaCare streamlines prior authorizations for physician-administered drugs across providers, pharmaceutical companies, and hub services. Its platform uses drug-specific smart forms, tracks the authorization workflow, and delivers actionable data while integrating with hub services and consolidating insurer portals for prescribers. These features help prevent delays, reduce administrative work, and ensure compliance, setting SamaCare apart with tailored forms and end-to-end integration. The goal is to speed up patient access to medications by making prior authorizations smoother and more reliable.

About SamaCare

Simplify's Rating
Why SamaCare is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & Analytics

Enterprise Software

Healthcare

Company Size

11-50

Company Stage

Series B

Total Funding

$34.8M

Headquarters

San Francisco, California

Founded

2018

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Simplify's Take

What believers are saying

  • SamaCare ranked No. 1021 on the 2026 Inc. 5000, its third straight appearance.
  • CMS proposed October 2027 medical-benefit prior-authorization APIs, expanding SamaCare's addressable workflow.
  • Its 2026 benchmarks create a market-access product for manufacturers and specialty providers.

What critics are saying

  • CoverMyMeds, Availity, and Epic can bundle prior-authorization automation into existing enterprise relationships.
  • CMS's 2027 API mandate commoditizes portals, shrinking SamaCare's switching costs and pricing power.
  • A payer-native workflow makes specialty providers bypass SamaCare, collapsing its middleman role.

What makes SamaCare unique

  • SamaCare owns a proprietary medical-benefit prior-authorization dataset spanning $6.2 billion in 2025 volume.
  • Its Q2 2026 benchmarks quantify net approval rates and time-to-resolution across specialties.
  • It serves 40% of U.S. ambulatory infusion centers, embedding workflow into buy-and-bill care.

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Funding

Total Funding

$34.8M

Below

Industry Average

Funded Over

4 Rounds

Series B funding is typically for startups that have proven their business model and need more funding to expand rapidly—often by entering new markets or adding more products. Investors are usually venture capital firms that specialize in later-stage investments.
Series B Funding Comparison
Below Average

Industry standards

$35M
$30M
Patreon
$45M
Linktree
$65M
Substack
$100M
ClickUp

Growth & Insights and Company News

Headcount

6 month growth

-1%

1 year growth

-3%

2 year growth

2%
PR Newswire
Aug 11th, 2026
SamaCare ranks in top 25% of 2026 Inc. 5000 for third consecutive year.

SamaCare ranks in top 25% of 2026 Inc. 5000 for third consecutive year. Aug 11, 2026, 07:02 ET AI-powered prior authorization company named No. 1021, reflecting continued growth of its platform for specialty practices and market access teams SAN FRANCISCO, Aug. 11, 2026 /PRNewswire/ - SamaCare, the AI-powered medical benefit prior authorization platform, today announced it has been ranked No. 1021 on the 2026 Inc. 5000 list, placing the company in the top 25% of America's fastest-growing private companies for the third consecutive year. SamaCare's continued recognition reflects growing demand for technology that helps specialty practices, pharmaceutical manufacturers, and patient access teams reduce administrative barriers between prescription and treatment start. Over the past year, SamaCare has expanded its AI prior authorization platform, introduced an insights solution for life sciences market access teams, and published the industry's first Market Access Benchmarks for medical benefit prior authorization performance. "Being named to the Inc. 5000 list for the third year running is a meaningful milestone for our team, but the real story is the problem we are helping the industry solve," said Syam Palakurthy, Founder and CEO of SamaCare. "Specialty practices are navigating increasingly complex payer requirements, while life sciences teams need clearer visibility into the access barriers that affect whether patients can start and stay on therapy. Our growth reflects the urgency of that need, and our continued focus on using AI, workflow automation, and real-world access data to help patients receive the treatments their physicians prescribe." SamaCare's platform unifies prior authorization workflows for provider-administered specialty medications across payers and plans. By combining automation, payer policy intelligence, workflow data, and AI-driven insights, SamaCare helps practices reduce administrative burden while giving life sciences teams a clearer view into patient access barriers that are difficult to see through claims or traditional hub data alone. In 2026, SamaCare launched its Market Access Benchmarks, the first public benchmarks focused on medical benefit prior authorization performance. The benchmarks provide quarterly visibility into net approval rates and time to resolution across medical benefit drugs, helping market access, patient services, and provider engagement teams better understand where access friction occurs and where targeted interventions may improve patient starts. SamaCare has also continued to expand its insights solution for market access teams, enabling life sciences organizations to identify payer, provider, specialty, and workflow-level barriers that can affect therapy uptake. These insights help teams move beyond lagging indicators and better understand the real-world administrative pathways patients and providers must navigate after a therapy is prescribed. "Every company on the Inc. 5000 has a story of perseverance, smart decision making, and a refusal to sit still," said Mike Hofman, editor-in-chief of Inc. "Their growth reflects more than strong financial performance; it reflects creativity, resilience, and the customer focus required to build companies that make a lasting impact. We congratulate all honorees on this significant achievement." For the full Inc. 5000 list, honoree company profiles, and a searchable database by industry and location, visit www.inc.com/inc5000. About SamaCare SamaCare is an AI-powered insights and interventions platform designed to accelerate patient access to specialty therapies by unifying and optimizing the prior authorization process for provider-administered medications. The platform aggregates and analyzes real-world data from millions of prior authorizations across a nationwide network of providers, delivering actionable insights and in-workflow support that reduce delays, denials, and therapy abandonment. SamaCare partners with pharmaceutical manufacturers, providers, and patient access teams to improve the script-to-therapy journey and help patients start and stay on treatment. For more information, visit www.samacare.com. SOURCE SamaCare

PR Newswire
Apr 23rd, 2026
SamaCare releases first medical benefit prior authorisation benchmarks for specialty drugs

SamaCare, a platform for medical benefit prior authorisation, has released the first-of-its-kind Medical Benefit Prior Authorization Benchmarks, providing life sciences companies and healthcare providers with unprecedented visibility into approval rates and time to therapy for specialty medications. The benchmarks, derived from tens of thousands of specialty practices using SamaCare, track two critical metrics: net approval rate and mean time to resolution. The data can be explored across specialties and tracked quarterly, offering insights into how access conditions evolve over time. The release addresses a significant transparency gap in understanding how prior authorisation impacts patient access to care. SamaCare aggregates the largest real-world dataset of medical benefit prior authorisations in the United States. The benchmarks will be updated quarterly and expanded to include additional metrics.

Baker City Herald
Mar 24th, 2026
SamaCare named to Fast Company's 2026 Most Innovative Companies list.

SamaCare named to Fast Company's 2026 Most Innovative Companies list. PR Newswire Today at 4:01am PDT SamaCare ranks No. 14 in Healthcare for advancing AI-driven patient access to specialty therapies SAN FRANCISCO, March 24, 2026 /PRNewswire/ - SamaCare, an AI-powered insights and interventions platform accelerating patient access to specialty therapies, today announced it has been named No. 14 in the Healthcare category on Fast Company's 2026 Most Innovative Companies list. SamaCare named to Fast Company's 2026 Most Innovative Companies list, ranks 14th for Most Innovative healthcare company. The recognition highlights SamaCare's work transforming one of healthcare's most persistent barriers: the administrative complexity of prior authorization. By combining real-world medical benefit prior authorization data with AI-driven workflow support, SamaCare enables specialty medical practices and pharmaceutical teams to reduce delays, prevent avoidable denials, and help patients start therapy faster. "We're honored to be recognized by Fast Company for the work we're doing to improve how patients access critical therapies," said Syam Palakurthy, CEO and Founder of SamaCare. "There is a part of healthcare that is inherently complex, but there is also a large part that is unnecessarily difficult. At SamaCare, we focus on removing administrative obstacles by turning real-world data into actionable intelligence and embedding it directly into provider workflows. The goal is simple: help patients get on the right treatment as quickly as possible." Prior authorization has become one of the most significant operational and clinical barriers in the healthcare system, often delaying treatment and contributing to negative health outcomes. SamaCare addresses this challenge by unifying prior authorization workflows across payers and plans and layering in AI-powered guidance that helps providers navigate requirements in real time, and take proven steps to reduce delays and avoidable denials. In the past 12 months, the company introduced several key innovations, including: * SamaCare Insights: a data platform built from millions of real-world prior authorizations, giving pharmaceutical market access teams visibility into the patient journey and root causes of delays, denials, and therapy abandonment * AI-Powered Point-of-Care Support: in-workflow guidance that helps providers automate the creation and submission of prior authorizations, avoid common errors, select optimal submission pathways, and respond to payer requirements more efficiently * Policy Pre-Check: a proprietary AI capability that evaluates submissions against payer policies before they are sent, helping prevent avoidable denials that can delay care by weeks These innovations have translated into measurable impact across SamaCare's network, including up to a 42% reduction in avoidable administrative denials, a 24% decrease in therapy abandonment, and approximately 80% faster time-to-therapy for patients. By transforming fragmented administrative processes into a unified, data-driven system, SamaCare is enabling providers, pharmaceutical companies, and patient access teams to better understand and address the barriers that prevent patients from receiving prescribed treatments. The full list of Fast Company's Most Innovative Companies honorees can be found at: https://www.fastcompany.com/most-innovative-companies/2026 About SamaCare SamaCare is an AI-powered insights and interventions platform designed to accelerate patient access to specialty therapies by unifying and optimizing the prior authorization process for provider-administered medications. The platform aggregates and analyzes real-world data from millions of prior authorizations across a nationwide network of providers, delivering actionable insights and in-workflow support that reduce delays, denials, and therapy abandonment. SamaCare partners with pharmaceutical manufacturers, providers, and patient access teams to improve the script-to-therapy journey and help patients start and stay on treatment. For more information visit www.samacare.com SOURCE SamaCare This is a paid placement. For further inquiries, please contact PR Newswire directly.

PR Newswire
Aug 12th, 2025
SamaCare Ranks No. 578 on the 2025 Inc. 5000 List of America's Fastest-Growing Private Companies

SamaCare ranks No. 578 on the 2025 Inc. 5000 list of America's Fastest-Growing private companies.

PR Newswire
Jun 12th, 2025
Samacare Celebrates One Million Medical Benefit Drug Prior Authorizations, Made Fast, Easy, And Accurate With Ai

SAN FRANCISCO, June 12, 2025 /PRNewswire/ -- SamaCare, a cloud-based patient access platform for specialty medications, today announced that it has passed the 1MM milestone in prior authorizations resolved for specialty practices. "We're excited to reach this milestone in our journey to help providers streamline the Script-to-Therapy process, and get patients the critical treatments they need, when they need them," said SamaCare CEO Syam Palakurthy. "By combining the power of AI and human expertise, we can leverage insights from over one million resolved prior authorizations to make SamaCare exponentially better at understanding and eliminating the friction patients and providers face from the time a diagnosis is made to the time treatment is administered."

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