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SamaCare

Optimizes prior authorizations for physician-administered drugs

Overview

SamaCare streamlines prior authorizations for physician-administered drugs across providers, pharmaceutical companies, and hub services. Its platform uses drug-specific smart forms, tracks the authorization workflow, and delivers actionable data while integrating with hub services and consolidating insurer portals for prescribers. These features help prevent delays, reduce administrative work, and ensure compliance, setting SamaCare apart with tailored forms and end-to-end integration. The goal is to speed up patient access to medications by making prior authorizations smoother and more reliable.

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About SamaCare

Simplify's Rating
Why SamaCare is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & AnalyticsEnterprise SoftwareHealthcare

Company Size

11-50

Company Stage

Series B

Total Funding

$34.8M

Headquarters

San Francisco, California

Founded

2018

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Simplify's Take

What believers are saying

  • February 2026 showed $6.2 billion in 2025 PA volume across specialty practices.
  • August 2026 Inc. 5000 ranked SamaCare in the top 25% for third year.
  • The platform now serves 40% of U.S. ambulatory infusion centers, expanding distribution.

What critics are saying

  • CoverMyMeds and payer portals still own submission workflows, compressing SamaCare's enterprise pricing power.
  • Q2 2026 approval rates fell to 76.5%, exposing payer policy tightening.
  • If manufacturers stop sponsoring interventions, SamaCare's access-insights moat weakens by 2027.

What makes SamaCare unique

  • SamaCare's Q2 2026 benchmarks span 30,000+ specialty practices and 2M prior authorizations.
  • Its November 2025 SamaCare Plus automates end-to-end authorizations while keeping provider control.
  • July 2026 benchmarks and life-sciences insights turn workflow data into market-access intelligence.

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Funding

Total Funding

$34.8M

Below

Industry Average

Funded Over

4 Rounds

Series B funding is typically for startups that have proven their business model and need more funding to expand rapidly—often by entering new markets or adding more products. Investors are usually venture capital firms that specialize in later-stage investments.
Series B Funding Comparison
Below Average

Industry standards

$35M
$30M
$45M
$65M
$100M

Growth & Insights and Company News

Headcount

6 month growth

2%

1 year growth

4%

2 year growth

2%
PR Newswire
Aug 13th, 2026
SamaCare named 2026 Prix Galien USA finalist for Best Digital Health Solution.

SamaCare named 2026 Prix Galien USA finalist for Best Digital Health Solution. Aug 13, 2026, 07:05 ET Recognition honors SamaCare's AI-powered Medical Benefit Prior Authorization Intelligence Platform for helping patients access specialty therapies faster SAN FRANCISCO, Aug. 13, 2026 /PRNewswire/ - SamaCare, the AI-powered medical benefit prior authorization intelligence platform, today announced it has been named a 2026 Prix Galien USA finalist in the Best Digital Health Solution category for its AI-powered Medical Benefit Prior Authorization Intelligence Platform. Widely regarded as one of the most prestigious honors in life sciences innovation, the Prix Galien recognizes breakthroughs with the potential to improve human health. SamaCare was selected among 23 Best Digital Health Solution nominees in a year marking the 20th anniversary of the Prix Galien USA Awards. For patients prescribed specialty therapies for cancer, autoimmune disease, neurologic disease, retinal disease, and other serious or progressive conditions, the next step after diagnosis should be treatment. Instead, many face a complex administrative journey before therapy can begin, including benefits verification, prior authorization, payer review, step therapy, appeals, follow-up, scheduling, and rescheduling. These delays can mean disease progression, relapse, anxiety, treatment non-starts, and worsening outcomes. SamaCare was founded to address that gap between prescription and treatment start. The company's platform transforms fragmented medical benefit prior authorization into intelligent healthcare infrastructure, helping providers navigate payer requirements, reduce administrative burden, and move patients to therapy faster. "Every breakthrough therapy solves one scientific challenge: how to treat disease," said Syam Palakurthy, Founder and CEO of SamaCare. "But there is another challenge that determines whether innovation reaches patients: whether people can actually access the therapies their physicians prescribe. Being named a Prix Galien USA finalist is deeply meaningful because this award recognizes health impact. Our team is focused on making sure patients do not get stuck in administrative limbo after their doctor has already decided what treatment they need." Medical benefit prior authorization remains one of healthcare's most fragmented access challenges. Unlike retail pharmacy workflows, medical benefit therapies are often administered in specialty practices, infusion centers, or physician offices, with payer requirements that vary by plan, therapy, site of care, diagnosis, documentation, and route of administration. For patients with serious or progressive disease, delays can carry clinical consequences. For providers, the process consumes staff time that could otherwise support patient care. SamaCare's platform unifies prior authorization creation, submission, tracking, and management across payers and plans. By combining workflow automation, payer policy intelligence, AI-driven guidance, and real-world provider data, SamaCare helps specialty practices anticipate requirements, avoid preventable delays and denials, and maintain visibility into authorizations in flight. The platform also converts millions of prior authorization interactions into real-world patient access intelligence. This gives life sciences market access, patient services, and provider engagement teams a clearer view into the administrative barriers patients and providers encounter after a therapy is prescribed. These insights can help identify access friction earlier, inform targeted provider support, and improve the script-to-therapy journey. "SamaCare's innovation is not AI for AI's sake," Palakurthy added. "It is AI applied to one of the least visible but most consequential parts of healthcare: the operational path between a prescription and a patient actually receiving treatment. Our goal is to make that path faster, clearer, and less painful for the providers and patients navigating it every day." SamaCare supports provider-administered specialty medications across oncology, ophthalmology/retina, neurology, rheumatology, immunology, gastroenterology, rare disease, ambulatory infusion, and other specialty care settings. Its intelligent system for medical benefit prior authorization has helped reduce delays, denials, and therapy abandonment while creating a new source of real-world access intelligence for the healthcare ecosystem. About SamaCare SamaCare is an AI-powered insights and interventions platform designed to accelerate patient access to specialty therapies by unifying and optimizing the prior authorization process for provider-administered medications. The platform aggregates and analyzes real-world data from millions of prior authorizations across a nationwide network of providers, delivering actionable insights and in-workflow support that reduce delays, denials, and therapy abandonment. SamaCare partners with pharmaceutical manufacturers, providers, and patient access teams to improve the script-to-therapy journey and help patients start and stay on treatment. For more information, visit www.samacare.com. About The Galien Foundation The Galien Foundation fosters, recognizes, and rewards excellence in scientific innovation to improve human health. Established in Paris in 1970 in honor of Galen, the father of medical science and modern pharmacology, the Prix Galien is widely regarded as the equivalent of the Nobel Prize in biopharmaceutical research. Today, the Prix Galien operates through 16 chapters spanning more than 75 countries across Africa, the Americas, Asia, and Europe. For more information, visit www.galienfoundation.org. SOURCE SamaCare

PR Newswire
Aug 11th, 2026
SamaCare ranks in top 25% of 2026 Inc. 5000 for third consecutive year.

SamaCare ranks in top 25% of 2026 Inc. 5000 for third consecutive year. Aug 11, 2026, 07:02 ET AI-powered prior authorization company named No. 1021, reflecting continued growth of its platform for specialty practices and market access teams SAN FRANCISCO, Aug. 11, 2026 /PRNewswire/ - SamaCare, the AI-powered medical benefit prior authorization platform, today announced it has been ranked No. 1021 on the 2026 Inc. 5000 list, placing the company in the top 25% of America's fastest-growing private companies for the third consecutive year. SamaCare's continued recognition reflects growing demand for technology that helps specialty practices, pharmaceutical manufacturers, and patient access teams reduce administrative barriers between prescription and treatment start. Over the past year, SamaCare has expanded its AI prior authorization platform, introduced an insights solution for life sciences market access teams, and published the industry's first Market Access Benchmarks for medical benefit prior authorization performance. "Being named to the Inc. 5000 list for the third year running is a meaningful milestone for our team, but the real story is the problem we are helping the industry solve," said Syam Palakurthy, Founder and CEO of SamaCare. "Specialty practices are navigating increasingly complex payer requirements, while life sciences teams need clearer visibility into the access barriers that affect whether patients can start and stay on therapy. Our growth reflects the urgency of that need, and our continued focus on using AI, workflow automation, and real-world access data to help patients receive the treatments their physicians prescribe." SamaCare's platform unifies prior authorization workflows for provider-administered specialty medications across payers and plans. By combining automation, payer policy intelligence, workflow data, and AI-driven insights, SamaCare helps practices reduce administrative burden while giving life sciences teams a clearer view into patient access barriers that are difficult to see through claims or traditional hub data alone. In 2026, SamaCare launched its Market Access Benchmarks, the first public benchmarks focused on medical benefit prior authorization performance. The benchmarks provide quarterly visibility into net approval rates and time to resolution across medical benefit drugs, helping market access, patient services, and provider engagement teams better understand where access friction occurs and where targeted interventions may improve patient starts. SamaCare has also continued to expand its insights solution for market access teams, enabling life sciences organizations to identify payer, provider, specialty, and workflow-level barriers that can affect therapy uptake. These insights help teams move beyond lagging indicators and better understand the real-world administrative pathways patients and providers must navigate after a therapy is prescribed. "Every company on the Inc. 5000 has a story of perseverance, smart decision making, and a refusal to sit still," said Mike Hofman, editor-in-chief of Inc. "Their growth reflects more than strong financial performance; it reflects creativity, resilience, and the customer focus required to build companies that make a lasting impact. We congratulate all honorees on this significant achievement." For the full Inc. 5000 list, honoree company profiles, and a searchable database by industry and location, visit www.inc.com/inc5000. About SamaCare SamaCare is an AI-powered insights and interventions platform designed to accelerate patient access to specialty therapies by unifying and optimizing the prior authorization process for provider-administered medications. The platform aggregates and analyzes real-world data from millions of prior authorizations across a nationwide network of providers, delivering actionable insights and in-workflow support that reduce delays, denials, and therapy abandonment. SamaCare partners with pharmaceutical manufacturers, providers, and patient access teams to improve the script-to-therapy journey and help patients start and stay on treatment. For more information, visit www.samacare.com. SOURCE SamaCare

PR Newswire
Apr 23rd, 2026
SamaCare releases first medical benefit prior authorisation benchmarks for specialty drugs

SamaCare, a platform for medical benefit prior authorisation, has released the first-of-its-kind Medical Benefit Prior Authorization Benchmarks, providing life sciences companies and healthcare providers with unprecedented visibility into approval rates and time to therapy for specialty medications. The benchmarks, derived from tens of thousands of specialty practices using SamaCare, track two critical metrics: net approval rate and mean time to resolution. The data can be explored across specialties and tracked quarterly, offering insights into how access conditions evolve over time. The release addresses a significant transparency gap in understanding how prior authorisation impacts patient access to care. SamaCare aggregates the largest real-world dataset of medical benefit prior authorisations in the United States. The benchmarks will be updated quarterly and expanded to include additional metrics.

Baker City Herald
Mar 24th, 2026
SamaCare named to Fast Company's 2026 Most Innovative Companies list.

SamaCare named to Fast Company's 2026 Most Innovative Companies list. PR Newswire Today at 4:01am PDT SamaCare ranks No. 14 in Healthcare for advancing AI-driven patient access to specialty therapies SAN FRANCISCO, March 24, 2026 /PRNewswire/ - SamaCare, an AI-powered insights and interventions platform accelerating patient access to specialty therapies, today announced it has been named No. 14 in the Healthcare category on Fast Company's 2026 Most Innovative Companies list. SamaCare named to Fast Company's 2026 Most Innovative Companies list, ranks 14th for Most Innovative healthcare company. The recognition highlights SamaCare's work transforming one of healthcare's most persistent barriers: the administrative complexity of prior authorization. By combining real-world medical benefit prior authorization data with AI-driven workflow support, SamaCare enables specialty medical practices and pharmaceutical teams to reduce delays, prevent avoidable denials, and help patients start therapy faster. "We're honored to be recognized by Fast Company for the work we're doing to improve how patients access critical therapies," said Syam Palakurthy, CEO and Founder of SamaCare. "There is a part of healthcare that is inherently complex, but there is also a large part that is unnecessarily difficult. At SamaCare, we focus on removing administrative obstacles by turning real-world data into actionable intelligence and embedding it directly into provider workflows. The goal is simple: help patients get on the right treatment as quickly as possible." Prior authorization has become one of the most significant operational and clinical barriers in the healthcare system, often delaying treatment and contributing to negative health outcomes. SamaCare addresses this challenge by unifying prior authorization workflows across payers and plans and layering in AI-powered guidance that helps providers navigate requirements in real time, and take proven steps to reduce delays and avoidable denials. In the past 12 months, the company introduced several key innovations, including: * SamaCare Insights: a data platform built from millions of real-world prior authorizations, giving pharmaceutical market access teams visibility into the patient journey and root causes of delays, denials, and therapy abandonment * AI-Powered Point-of-Care Support: in-workflow guidance that helps providers automate the creation and submission of prior authorizations, avoid common errors, select optimal submission pathways, and respond to payer requirements more efficiently * Policy Pre-Check: a proprietary AI capability that evaluates submissions against payer policies before they are sent, helping prevent avoidable denials that can delay care by weeks These innovations have translated into measurable impact across SamaCare's network, including up to a 42% reduction in avoidable administrative denials, a 24% decrease in therapy abandonment, and approximately 80% faster time-to-therapy for patients. By transforming fragmented administrative processes into a unified, data-driven system, SamaCare is enabling providers, pharmaceutical companies, and patient access teams to better understand and address the barriers that prevent patients from receiving prescribed treatments. The full list of Fast Company's Most Innovative Companies honorees can be found at: https://www.fastcompany.com/most-innovative-companies/2026 About SamaCare SamaCare is an AI-powered insights and interventions platform designed to accelerate patient access to specialty therapies by unifying and optimizing the prior authorization process for provider-administered medications. The platform aggregates and analyzes real-world data from millions of prior authorizations across a nationwide network of providers, delivering actionable insights and in-workflow support that reduce delays, denials, and therapy abandonment. SamaCare partners with pharmaceutical manufacturers, providers, and patient access teams to improve the script-to-therapy journey and help patients start and stay on treatment. For more information visit www.samacare.com SOURCE SamaCare This is a paid placement. For further inquiries, please contact PR Newswire directly.

PR Newswire
Aug 12th, 2025
SamaCare Ranks No. 578 on the 2025 Inc. 5000 List of America's Fastest-Growing Private Companies

SamaCare ranks No. 578 on the 2025 Inc. 5000 list of America's Fastest-Growing private companies.

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