Saphetor announces appointment of Esteban Czwan as Chief Commercial Officer. Lausanne, Switzerland, 10th December 2025 - Saphetor SA, a Swiss precision medicine company and creator of the VarSome suite of bioinformatics solutions, today announced the appointment of Esteban Czwan as Chief Commercial Officer, effective 5th December 2025. Esteban will be responsible for global commercial strategy and activity as Saphetor continues its expansion into key markets. "We are all very excited by Esteban's arrival. We are confident that his extensive experience and skills will greatly contribute to our growth and to better outcomes for our customers," said Andreas Massouras, CEO, Saphetor SA. Esteban is a passionate healthcare leader with more than 15 years of experience in genomics, multiomics, and AI-driven clinical decision support systems. During his last position at Centogene as Executive Vice President and General Manager Diagnostics, he led its clinical diagnostics business, securing double-digit growth as a rare disease and oncology service provider until its recent acquisition. Previously, Esteban has held several commercial positions with increasing responsibility at Sophia Genetics, which he helped grow from a promising genomics start-up to a publicly traded company. Esteban also has many years of experience developing and supporting business at in-vitro diagnostics and instrument manufacturers, Devyser and Roche Diagnostics, where he held commercial and customer support roles, respectively. Before joining the healthcare industry, Esteban completed his doctoral research at the German Cancer Research Center, where he investigated methods to stratify cancer patients and predict prognosis based on gene expression data. Previously, he received his Master's in Bioinformatics from Cardiff University and his Bachelor's in Computer Science from the University of Illinois at Springfield. "I am humbled to join such a talented and healthy company, a unique combination in our industry. I thank Andreas for trusting me to lead the commercial organization through the next phase of growth." Esteban Czwan CCO, Saphetor SA. About Saphetor SA Saphetor SA is a global precision-medicine company dedicated to large-scale identification and interpretation of human genetic variants by leveraging proprietary algorithms and expert domain knowledge. Saphetor is the creator of VarSome, a suite of intuitive and data-driven bioinformatics solutions both for clinicians and researchers. VarSome.com, a professional community and search engine, is freely accessible, featuring a widely-recognized community-driven knowledge base that enables flexible queries across more than 140 genetic and genomic data resources. VarSome Premium and VarSome Clinical are professional editions of VarSome with powerful functionality and further sophisticated data-mining and analysis tools. VarSome Clinical is a CE-IVDR-certified and HIPAA-compliant platform allowing fast and accurate variant discovery, annotation, and interpretation of NGS data for whole genomes, exomes, and gene panels, which helps clinicians reach faster and more accurate diagnoses and treatment decisions for genetic conditions. VarSome can also be integrated into existing in-house pipelines via VarSome API through cloud-based or on-premises installations.

LongSeq has been working with Oxford Nanopore Technologies for years, applying long read sequencing to genetically complex clinical cases.