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SonoThera

Ultrasound-mediated nonviral gene therapy platform

Overview

SonoThera develops ultrasound-mediated nonviral genetic medicines for targeted, repeatable delivery of DNA and RNA therapeutics. Its platform combines RIPPLE ultrasound delivery with PORE payload engineering to control gene expression, editing, and silencing across tissues such as muscle, heart, liver, kidney, fat, and brain, using standard diagnostic ultrasound systems and commercial contrast agents. This approach aims to provide targeted, nonviral gene delivery with reroutable dosing and tissue specificity, distinguishing it from viral delivery and other nonviral methods through its ultrasound-driven routing and payload customization. Lead programs focus on Duchenne muscular dystrophy (DMD) and autosomal dominant polycystic kidney disease (ADPKD), with first DMD clinical trials expected in 2027. In June 2026 SonoThera closed a $125 million Series B to advance lead programs into the clinic and grow the pipeline.

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About SonoThera

Simplify's Rating
Why SonoThera is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

BiotechnologyHealthcare

Company Size

51-200

Company Stage

Series B

Total Funding

$185.8M

Headquarters

South San Francisco, CA

Founded

2022

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What believers are saying

  • June 10, 2026 Series B raised $125 million led by Vida Ventures.
  • September 14, 2026 hired BridgeBio Gene Therapy veteran Adam Shaywitz as CMO.
  • October 5, 2026 Fierce 15 recognition strengthened recruiting and partnering credibility.

What critics are saying

  • First DMD clinical trial slips until 2027, leaving no human efficacy data today.
  • Platform success depends on ultrasound precision, tissue targeting, and regulator acceptance.
  • Any liver, immune, or vascular toxicity would cripple redosing claims and destroy the thesis.

What makes SonoThera unique

  • RIPPLE ultrasound plus PORE payload engineering targets redosable, nonviral delivery across organs.
  • Diagnostic ultrasound and commercial microbubbles lower manufacturing complexity versus viral vectors.
  • Full-length dystrophin delivery sidesteps AAV cargo limits in DMD.

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Funding

Total Funding

$185.8M

Above

Industry Average

Funded Over

2 Rounds

Series B funding is typically for startups that have proven their business model and need more funding to expand rapidly—often by entering new markets or adding more products. Investors are usually venture capital firms that specialize in later-stage investments.
Series B Funding Comparison
Above Average

Industry standards

$35M
$45M
$65M
$100M
$125M

Benefits

  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • 401(k) Company Match
  • Unlimited Paid Time Off
  • Gym Membership
  • Commuter Benefits
  • Company Equity

Growth & Insights and Company News

6 month growth

3%

1 year growth

1%

2 year growth

6%
Nikkei
Nov 2nd, 2026
Otsuka Pharmaceutical's U.S. CVC invests in local startups, collaborating in rare diseases and other areas

Otsuka Pharmaceutical's U.S. CVC invests in local startups, collaborating in rare diseases and other areas November 2, 2026, 12:59 Otsuka Pharmaceutical announced that a corporate venture capital (CVC) fund under its U.S. subsidiary has begun investing in local startups in earnest. It will strengthen collaboration with emerging companies that have innovative technologies in disease areas where Otsuka Pharmaceutical focuses, such as neurological and rare diseases. Otsuka BioVentures (OBV), a CVC under Otsuka America, the U.S. subsidiary, has started full-scale investment activities. As its first deal, it invested in June in SonoThera Therapeutics, which develops a non-viral gene therapy platform using ultrasound. It has already completed a second investment as well. OBV invests in startups with innovative technologies in disease areas that Otsuka Pharmaceutical focuses on, including psychiatric, neurological, renal, and immunological diseases. Through OBV, Otsuka Pharmaceutical aims to strengthen collaboration with promising startups and achieve innovation and strengthen its business portfolio. This article uses generative AI technology as part of the editing process. The generated results are not used as-is; editors and reporters review, add to, and revise them before publication. Unlimited reading of all articles; paid members: 4,277 yen per month An AI trained on articles from the Nikkei Electronic Edition

BioSpectrum Asia
Oct 28th, 2026
Japan's Otsuka BioVentures begins strategic equity investments.

Japan's Otsuka BioVentures begins strategic equity investments. October 28, 2026 | Wednesday | News To provide portfolio companies with access to Otsuka Pharmaceutical's expertise in drug development and commercialisation. Japan-based Otsuka Pharmaceutical has announced that Otsuka BioVentures, LLC (OBV), a corporate venture capital (CVC) firm has begun strategic equity investments. OBV will make strategic equity investments in promising startup companies developing innovative science and technologies that complement and expand Otsuka Pharmaceutical's internal R&D efforts in its key focus areas including psychiatry, neurology, nephrology, and immunology. Through these investments, OBV aims to provide portfolio companies with access to Otsuka Pharmaceutical's expertise in drug development and commercialisation, while broadening access to cutting-edge science and technologies and fostering opportunities for future partnerships In June of this year, OBV participated in the Series B financing round of US-based SonoThera Therapeutics as its first investment. SonoThera is developing a non-viral gene therapy platform that utilises ultrasound technology for the treatment of Duchenne muscular dystrophy (DMD) and autosomal dominant polycystic kidney disease (ADPKD). The proceeds from the financing are expected to support the advancement of these programs. OBV has already made its second investment and continues to actively pursue investment opportunities in promising life sciences companies. +Country Code-Phone Number(xxx-xxxxxxx) New User? Create Account Survey box. Is Asia Pacific region racing towards greener & sustainable pharma?

FirstWord Pharma
Oct 26th, 2026
Otsuka launches BioVentures venture arm, backing SonoThera's Series B as first investment

Otsuka Pharmaceutical has launched strategic equity investments through Otsuka BioVentures (OBV), a corporate venture capital firm based in Princeton, New Jersey, US. OBV sits under Otsuka America, a wholly owned subsidiary of the company. OBV will back startups developing science and technologies that complement Otsuka's research in psychiatry, neurology, nephrology, and immunology. It aims to give portfolio companies access to Otsuka's drug development and commercialisation expertise. In June, OBV joined the Series B round of SonoThera Therapeutics of South San Francisco, California, as its first investment. SonoThera is developing an ultrasound-based, non-viral gene therapy platform for Duchenne muscular dystrophy and autosomal dominant polycystic kidney disease. OBV has since made a second investment and is seeking more life sciences targets.

San Francisco Biotechnology Network
Oct 5th, 2026
Fierce Biotech, a Division of Forge, Names SonoThera a "Fierce 15" Biotech Company of 2026

Fierce Biotech, a Division of Forge, Names SonoThera a "Fierce 15" Biotech Company of 2026 SAN FRANCISCO-(BUSINESS WIRE)- #Fierce15-Fierce Biotech, a division of Forge, names SonoThera a "Fierce 15" Biotech Company of 2026 Click here to view original post

The National Law Review
Oct 5th, 2026
Fierce Biotech, a division of Forge, names SonoThera a "Fierce 15" Biotech company of 2026.

Fierce Biotech, a division of Forge, names SonoThera a "Fierce 15" Biotech company of 2026. Recognition highlights SonoThera's development of ultrasound-mediated gene delivery technology to advance the next generation of genetic medicines SAN FRANCISCO-(BUSINESS WIRE)-#Fierce15-SonoThera today announced that Fierce Biotech has named it as one of 2026's Fierce 15 biotechnology companies, designating it as one of the most innovative and promising private biotechnology companies in the industry. SonoThera is developing a nonviral gene delivery platform designed to overcome key limitations of existing delivery technologies and expand the potential of genetic medicines. By leveraging ultrasound-mediated delivery, the company aims to enable targeted delivery of genetic payloads to tissues that have historically been challenging to reach, creating new opportunities to treat a broad range of diseases. The recognition follows several significant milestones for SonoThera, including the closing of its oversubscribed $125 million Series B financing in June 2026, led by Vida Ventures, and the appointment of Adam J. Shaywitz, M.D., Ph.D., as Chief Medical Officer in September. "We are honored to be recognized among this year's Fierce 15 companies," said Kenneth Greenberg, Chief Executive Officer and Co-Founder, SonoThera. "Gene delivery remains one of the most significant challenges in realizing the full potential of genetic medicines. At SonoThera, we are developing a new approach using ultrasound to overcome these barriers and expand the possibilities for treating patients with serious diseases. This recognition reflects the dedication of our team and the progress we are making toward translating our technology into meaningful therapies." The Fierce 15 celebrates the spirit of being "fierce" - championing innovation and creativity, even in the face of intense competition. This is Fierce Biotech's 24th annual Fierce 15 selection. "For 24 years, the Fierce 15 has highlighted private biotechs doing some of the most interesting and ambitious work in the industry," said Ayla Ellison, Editor-in-Chief, Fierce Life Sciences and Healthcare. "This year's class arrives at a moment when momentum is returning to biotech, with more capital flowing and new opportunities opening up for promising companies. These 15 biotechs stand out for the strength of their science and the potential of their approaches to shape the next generation of medicines." An internationally recognized daily report reaching a network of over 300,000 biotech and pharma industry professionals, Fierce Biotech provides subscribers with an authoritative analysis of the day's top stories. Every year Fierce Biotech evaluates hundreds of early-stage companies from around the world for its annual Fierce 15 list, which is based on a variety of factors such as the strength of its technology, partnerships, venture backers and a competitive market position. About Fierce Biotech Fierce Biotech covers the biopharma waterfront, from drug development through the entire lifecycle - tracking regulatory approvals, payer negotiations, manufacturing, marketing, patent fights, government investigations and regulation, M&A deals and beyond. Our aim is to analyze the day's news, showing readers not only what they need to know, but why they need to know it. Beyond the daily, the Fierce Biotech team produces special reports that take stock of the industry's products and finances and shed new light on industry trends. About Forge Forge is a leading global B2B events and media company, connecting buyers and sellers across high-value industries through live events, trusted media brands, digital products and year-round communities. Powered by first-party data, technology and deep market expertise, Forge helps businesses discover opportunities, build the right relationships and stay engaged well beyond the event itself. It is a company guided by a single purpose, Moving Markets. About SonoThera SonoThera is developing an ultrasound-mediated, nonviral genetic medicine platform designed to deliver the next generation of safe, targeted, and redosable genetic medicines. By integrating proprietary RIPPLE(TM) ultrasound delivery with PORE(TM) payload engineering, the company is advancing a broad range of genetic medicine approaches, including DNA and RNA therapeutics, gene editing, and gene silencing. SonoThera's platform is designed to enable precise, durable gene expression across multiple tissues while addressing key limitations associated with viral delivery approaches. The company is advancing a pipeline of genetic medicines for serious diseases, including Duchenne muscular dystrophy and autosomal dominant polycystic kidney disease. SonoThera is headquartered in South San Francisco, California. For more information, visit www.sonothera.com. Media Contact Fierce Life Sciences Events Katie Orell Director of Marketing [email protected]

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