Overview

St. Luke’s Hospital is a faith-based nonprofit health system serving the St. Louis area, operating a 493-bed Chesterfield hospital and about 30 outpatient locations. It delivers care across more than 60 specialties through the St. Luke’s Center for Cancer Care, the Heart & Vascular Institute, and the Orthwein Brain & Spine Center, plus partnerships like the Cleveland Clinic alliance for heart care. It differentiates itself as an independent nonprofit with a strong community focus, a broad outpatient network, and a faith-based mission. Its goal is to provide comprehensive, accessible, high-quality care while reinvesting earnings into community health education and expanded access to services.