Symrise introduces Cellexora MD to Care & Wellness portfolio. Mar 31st, 2026 Courtesy of Symrise On March 31, 2026, Symrise announced the launch of Cellexora MD, a new cosmetic ingredient based on plant-based true exosomes, to its Care & Wellness portfolio. This ingredient is made from upcycled organic apple side streams in Italy, making it a natural-origin ingredient with exceptional stability and traceability. According to the company's press release, Cellexora MD allows manufacturers to support deep skin regeneration and long-term vitality while meeting growing consumer demand for efficacy, transparency and sustainability. The plant-derived extracellular vesicles act as biological messengers that facilitate cell-to-cell communication. The ingredient uses targeted interactions with keratinocytes, fibroblasts and macrophages to address the root causes of skin aging and support multi-layer protection. "These plant-derived exosomes bring nature's biological intelligence into premium skincare," said Nathalie Chevrot, global skin care category director at Symrise. "Cellexora MD helps strengthen long-term skin health, vitality and biological function over time. It adds a powerful component to Symrise's line-up of premium cosmetic ingredients. As consumers increasingly seek true effective skincare beyond correcting visible signs of aging, this innovation helps our customers lead the shift toward health span-driven skincare and advanced skin regeneration." Cellexora MD is an odorless white powder with 100% natural origin. Further, the ingredient has high water solubility to provide formulation flexibility and seamless integration into product application. The company's clinical data show a reduction in visible signs of aging within 30 days of use. Symrise will present Cellexora MD at in-cosmetics Global 2026 in Paris, France.

P-Hydroxyacetophenone (HAP) formulation guide. Mar 28, 2026 Leave a message A Comprehensive Analysis of Anti-inflammatory Mechanisms, Antiseptic Enhancement, and Brand Applications With the current strong growth of "Clean Beauty" and microbiome-based skincare, brands and OEM/ODM manufacturers are facing unprecedented formulation challenges. The emergence of p-hydroxyacetophenone provides a core foundation for building a modern "preservative-free system." I. In-depth academic exploration: the core mechanism of action of p-hydroxyacetophenone. In literature reviews and clinical trials, p-hydroxyacetophenone has demonstrated triple biological activity that surpasses that of a single preservative alternative: 1. (Preservative Boosting) p-Hydroxyacetophenone is not a legally recognized preservative in the regulations of many countries, but it has strong antibacterial potential. Its molecular structure can effectively act on the cell membrane of microorganisms, altering membrane permeability and transmembrane potential, causing bacterial cell contents to leak out. Formula Practice:When combined with diols such as 1,2-hexanediol, octyl glycol, or pentanediol, it produces a strong synergistic effect, supporting the broad-spectrum preservative ability of the entire formulation with very low addition levels (usually 0.1%-0.5%), especially showing excellent performance in antifungal activity. 2. (Inhibition of COX-2) Modern pharmacological studies have shown that p-hydroxyacetophenone can effectively inhibit the production of certain substances in the skin. Expression of Cyclooxygenase-2 (COX-2). Academic verification:By inhibiting the COX-2 pathway, p-hydroxyacetophenone can block contact dermatitis and neurogenic inflammation caused by external stimuli (such as UV radiation and surfactant stimulation) at the source, rapidly reduce transepidermal water loss (TEWL), and relieve stinging sensation. 3. Antioxidant and emerging melanin-inhibiting potential. In addition to its ability to scavenge ROS (reactive oxygen species), the latest cutting-edge ingredient research indicates that certain concentrations of p-hydroxyacetophenone show potential in inhibiting tyrosinase activity. This means that it may appear as a synergistic ingredient in skin-brightening formulas in the future, assisting in whitening and anti-photoaging. II. Analysis of supply chain structure and application by well-known brands. On the raw material supply side, the benchmark product for p-hydroxyacetophenone is SymSave(R) H, developed by Symrise, a global giant in fragrances and flavors. Since its introduction to the market in 2013, it has become the industry standard for balancing formulation protection and mildness. The "golden partnership" of terminal brands Repair and anti-allergy For example, Winona's star soothing serum and intensive care cream utilize HAP (Hydrocotic Angiotensin-Protective Agents) combined with purslane extract. HAP plays a crucial role in preservation and, as part of the soothing system, enhances redness reduction. It is also used in La Roche-Posay's simplified formula. Gentle and additive-free Facial mask liquid can easily trigger allergies to traditional preservatives. High-end facial masks on the market (such as some lines of Natural Beauty and Proya) mostly use a versatile and gentle base of "water + moisturizer + HAP + 1,2-hexanediol". extreme systems HAP maintains high stability within the extreme pH range of 2-11 without disrupting the emulsion system, and is widely used in high SPF sunscreens and premium shampoos that emphasize scalp microbiome. III. B2B R&D formulation guidance and compliance recommendations. If you are leading the development of a new product, here are some practical suggestions regarding the use of p-hydroxyacetophenone: * Dissolution process: p-Hydroxyacetophenone is in powder form. It is recommended to add it to a polyol phase (such as propylene glycol or butylene glycol) and heat to dissolve it, or add it to an aqueous phase heated to above 60°C and homogenize it thoroughly. Allow the system to cool down before proceeding with subsequent operations. * Odor masking: High-purity HAP has a faint almond-like odor. At a concentration of 0.5%, the effect is negligible, but for completely fragrance-free formulations, attention must be paid to managing the odor threshold between batches of raw materials. * Regulatory claims of advantages: Using this ingredient not only allows Makeupcatcher (jinhua) Cosmetics Co., Ltd. to successfully pass the EWG Green Safety Rating, but also aligns with CleanGredients' environmentally friendly and microbiome-friendly philosophy, providing strong storytelling and compliance endorsement.

Symrise AG reported record profitability for full year 2025, with organic sales growth of 2.8% and adjusted EBITDA margin increasing by 120 basis points. The German flavour and fragrance company achieved €3 billion in revenue for its Nutrition and Health segment and €1.9 billion for Scent and Care. The company delivered €50 million in efficiency gains, exceeding its €40 million target, and posted a record adjusted business free cash flow margin of 15.8%. Adjusted earnings per share rose 7.2% to €3.67. Symrise announced a €400 million share buyback programme and proposed increasing its dividend to €1.25 per share, marking 16 consecutive annual increases. However, the company expects a low single-digit decline in Q1 2026 organic sales due to challenging comparables and macroeconomic uncertainties.