U

Universal DX

Liquid biopsy colorectal cancer detection test

Overview

Universal Dx offers Signal-C®, a liquid biopsy test for colorectal cancer and advanced adenomas. The test analyzes a blood sample using multi-omics, computational biology, and machine learning to identify cancer signals, achieving 92% sensitivity and 94% specificity. Its collaboration with Quest Diagnostics and planned FDA approval help scale access through a major diagnostic network, differentiating it by scaled distribution and proven accuracy. The goal is to improve early detection, reduce cancer incidence and mortality, and make screening more accessible to the population.

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About Universal DX

Simplify's Rating
Why Universal DX is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Data & AnalyticsAI & Machine LearningBiotechnologyHealthcare

Company Size

51-200

Company Stage

Grant

Total Funding

$179.7M

Headquarters

Seville, Spain

Founded

2012

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Simplify's take

What believers are saying

  • SETT formalized €29.9 million in October 2026, extending Universal DX’s runway.
  • Universal DX expanded at Pegasus Park in July 2026 and plans to double headcount.
  • Quest’s October 2026 growth and oncology distribution strengthen downstream adoption for future Signal-C launch.

What critics are saying

  • Signal-C lacks FDA approval as of November 2026, blocking broad U.S. reimbursement.
  • Guardant’s Shield, ordered through Quest since March 2026, crowds Universal DX’s sales channel.
  • If Signal-C misses FDA clearance in 2027, Universal DX becomes a stranded R&D company.

What makes Universal DX unique

  • Signal-C pairs cfDNA methylation, fragmentation, and machine learning for colorectal screening.
  • Universal DX’s 2026 SETT round raised €62 million, backing expansion and commercialization.
  • Quest Diagnostics distribution gives Universal DX access to a nationwide U.S. ordering network.

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Funding

Total Funding

$179.7M

Above

Industry Average

Funded Over

13 Rounds

Grant funding comparison data is currently unavailable. We're working to provide this information soon!
Grant Funding Comparison Coming Soon

Benefits

  • Paid Vacation
  • Paid Holidays
  • Flexible Work Hours
  • Health Insurance
  • Dental Insurance
  • Vision Insurance
  • Life Insurance
  • Disability Insurance
  • Company Equity

Company News

Capital Riesgo
May 13th, 2026
Spain's SETT invests $34M in Universal DX's AI cancer detection technology

Spain's public investment vehicle SETT has finalised a €29.9 million investment in Spanish company Universal DX to advance its AI-powered early cancer detection technology. The investment, approved by the Council of Ministers in January, forms part of a €62 million funding round. Universal DX specialises in next-generation diagnostics using liquid biopsy for early cancer detection, primarily serving laboratories and diagnostic operators in the US. The company combines AI, machine learning and molecular analysis to identify DNA patterns with unique precision, achieving significantly higher sensitivity in detecting early-stage colorectal cancer and precancerous lesions than traditional methods. Universal DX is finalising commercial approval for its colorectal cancer detection test and developing similar tests for lung, liver, pancreatic and oesophageal cancers. The funding comes from the SETT's Next Tech facility, backed by EU Next Generation funds.

Capital Riesgo
May 13th, 2026
SETT formalizes the investment of 30 million euros in the Spanish company Universal DX.

SETT formalizes the investment of 30 million euros in the Spanish company Universal DX. The Spanish Society for Technological Transformation (SETT), a public entity attached to the Ministry for Digital Transformation and Public Function, has today formalized an investment of 29.9 million euros in the Spanish company Universal DX to boost its early cancer detection technology through the use of Artificial Intelligence. The operation, authorized by the Council of Ministers last January, is part of SETT's public-private partnership strategy. SETT is participating with this €30 million co-investment in a capital increase round in which the company has raised a total of €62 million from various investment partners. Javier Ponce, CEO of SETT, and Diego Broseta, CFO of Universal DX, formalized the investment. Universal Diagnostics (UDX) is a next-generation diagnostics company specializing in early cancer detection using liquid biopsy. Its clients are laboratories and large diagnostic operators in the U.S. This public investment, with which the Government continues to support the implementation of advanced technologies and digitalization in the health sector, will help the company develop a system that combines AI, machine learning and molecular analysis to identify patterns in DNA with unique accuracy. Unlike traditional techniques, its technology analyzes multiple levels of biological information in the blood, providing a more comprehensive view of the tumor's status. The process combines this analytical capability with a state-of-the-art digital infrastructure based on laboratory automation, big data management, and artificial intelligence. Thus, UDX achieves a much higher sensitivity than other tests in the early stages of colorectal cancer and in precancerous lesions, making it a pioneer in the field of cancer diagnostics. The company is finalizing commercial approval for its flagship colorectal cancer screening test and is developing similar tests for cancers such as lung, liver, pancreatic, and esophageal cancer. In a second phase, it will replicate the model in Europe. Throughout its history, UDX has collaborated with numerous Spanish academic centers that have contributed to developing cancer detection algorithms, including the Polytechnic University of Catalonia, the Polytechnic University of Valencia (UPV) and the Institute of Mathematics of the University of Seville (IMUS). SETT is carrying out this operation through its Next Tech facility, using funds from the Recovery, Transformation and Resilience Plan (Next Generation EU Funds), which aims to boost financing for startups and scale-ups in the technology sector. In addition, SETT manages two other facilities to strengthen the technology business ecosystem: PERTE Chip, dedicated to microelectronics and semiconductors, and Spain Audiovisual Hub, which promotes the digitalization of the audiovisual sector. Highlight. by Axon Partners Group cloud technology axon

Forbes España
Jan 20th, 2026
Spain invests €30M in AI cancer detection startup Universal DX

The Spanish government has approved a €30 million investment in Universal DX, a Spanish AI company specialising in early cancer detection. The funding will be channelled through the Spanish Society for Technological Transformation (SETT) as part of a €62 million capital increase round. Founded in 2012 with headquarters in Seville and offices in Madrid, Dallas and Ljubljana, Universal DX uses liquid biopsy technology to detect cancer early. The company's approach analyses multiple levels of biological information in blood, combining analytical capabilities with laboratory automation, big data management and artificial intelligence. The investment is expected to create 400 jobs—100 direct and 300 indirect positions. Universal DX is finalising commercial approval for its colorectal cancer detection test and developing similar tests for lung, liver, pancreatic and oesophageal cancers.

EU-Startups
Feb 27th, 2025
Universal DX secures €20 million loan from EIB to advance early cancer detection

Universal DX secures €20 million loan from EIB to advance early cancer detection.

European Investment Bank
Feb 27th, 2025
Spain: EIB finances with €20 million Universal DX to develop innovative diagnostic tests for early cancer detection

The European Investment Bank (EIB) has signed a €20 million loan with Spain company Universal DX to support development and commercialization of cutting-edge blood-based liquid biopsy solutions for the early detection of cancer. The survival rate of certain cancers such as colorectal cancer, can increase significantly if detected at an early stage.

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