ZBiotics

ZBiotics

Genetically engineered probiotics targeting acetaldehyde

Overview

ZBiotics creates genetically engineered probiotic supplements designed to break down acetaldehyde, a toxic byproduct of alcohol consumption. The product is taken as a probiotic pill that works in the gut to neutralize acetaldehyde after drinking, helping reduce hangover symptoms. It is sold directly to consumers via its website, with options for one-time purchases or subscriptions. ZBiotics differentiates itself by a clear, people-first approach and ongoing research into other health challenges (dairy intolerance, radiation exposure, lead contamination in water), alongside a commitment to transparency. The company’s goal is to help people manage the after-effects of alcohol while expanding probiotic science and exploring solutions for other health issues.

YC Company

About ZBiotics

Simplify's Rating
Why ZBiotics is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Consumer Goods

Company Size

51-200

Company Stage

Series A

Total Funding

$14.4M

Headquarters

San Francisco, California

Founded

2016

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Simplify's Take

What believers are saying

  • By July 2026, ZBiotics sold 15 million-plus Pre-Alcohol shots.
  • ZBiotics closed an oversubscribed $12 million Series A on July 21, 2026.
  • Sugar-to-Fiber launched in 2025, and 2026 coverage shows early traction.

What critics are saying

  • FDA still treats Pre-Alcohol as food, not an approved hangover treatment.
  • Self-affirmed GRAS and pending FDA submissions leave a 2026-2027 regulatory overhang.
  • If FTC attacks hangover claims, ZBiotics' DTC and hospitality channels stall quickly.

What makes ZBiotics unique

  • ZBiotics launched the first genetically engineered probiotic, Pre-Alcohol, before 2022 competitors.
  • Patented strains ZB183 and ZB423 target acetaldehyde and sugar conversion, respectively.
  • April 2026 hospitality partnerships put Pre-Alcohol inside bars across seven U.S. cities.

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Funding

Total Funding

$14.4M

Below

Industry Average

Funded Over

3 Rounds

Notable Investors:
Series A funding typically happens when a startup has a product and some customers, and now needs funding to scale. This money is usually used to grow the team, expand marketing, and improve the product. Venture capital firms are frequently the main investors here.
Series A Funding Comparison
Below Average

Industry standards

$15M
$8.2M
Discord
$12M
ZBiotics
$15M
Canva
$30M
Kalshi

Benefits

Health Insurance

Dental Insurance

401(k) Company Match

Unlimited Paid Time Off

Parental Leave

Home Office Stipend

Commuter Benefits

Hybrid Work Options

Remote Work Options

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

3%

2 year growth

0%
Popin
Jun 14th, 2026
ZBiotics floor display wins Silver OMA.

ZBiotics floor display wins Silver OMA. OMA Silver Award International partnered with ZBiotics to support its transition from a fast-growing direct-to-consumer brand into brick-and-mortar retail with a bold, modern floor display built to stand out in highly competitive store environments. Program Objective After gaining momentum as a direct-to-consumer brand starting in 2019, ZBiotics identified brick-and-mortar expansion as a strategic priority in early 2024. Entering convenience and liquor channels introduced a clear challenge: winning attention in crowded aisles where space is limited and visual competition is high. The objective was straightforward: create a compact, modern floor display that commands attention while preserving valuable floor space. The solution needed to be... Sources include: Great Northern instore

AgFunder
May 14th, 2025
Designer Probiotics Startup Zbiotics Has Sold 8 Million ‘Pre-Alcohol’ Shots, Launched New ‘Sugar To Fiber’ Product

“When I started ZBiotics, I was sure somebody would beat us to the punch,” says Dr. Zack Abbott, the microbiologist behind a genetically engineered probiotic serving as a hangover remedy that many consumers now swear by. “But when we launched three years later, we were the first to market with a genetically engineered probiotic [ZBiotics Pre-alcohol: a shot containing bacteria engineered to expresses an enzyme that breaks down a toxic byproduct of alcohol in the gut]. “Five years later, we launched our second product [ZBiotics Sugar-to-Fiber: which contains containing bacteria engineered to express an enzyme that converts sugars into fibers in the gut] and still nobody else had launched a GM probiotic. I’m not totally sure why, I think maybe there’s a fear that consumers will reject it, but we just haven’t seen that

Beverage Network
Sep 20th, 2024
New Products: Peet's First Concentrated Espresso, Plus Gatorade, Humm, Stash Tea & More

Biotechnology company Zbiotics has announced the launch of Sugar-to-Fiber Probiotic Drink Mix, which it claims to be the first product of its kind to hit the consumer market.

Business Wire
Aug 29th, 2024
ZBiotics, Maker of World’s First Genetically Engineered Probiotics, Raises $12M Series A

ZBiotics, the pioneers carving a new category of genetically engineered probiotics, today announced the close of its $12M Series A funding round, led

FinSMEs
Aug 27th, 2024
ZBiotics Raises $12M in Series A Funding

ZBiotics raises $12M in Series A funding.

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