Zevra Therapeutics

Zevra Therapeutics

Develops rare-disease therapies, including CNS

Overview

Zevra Therapeutics develops and commercializes therapies for rare diseases, focusing on CNS disorders with unmet needs. It grows its portfolio through in-house development and strategic acquisitions, including OLPRUVA for urea cycle disorders (acquired via Acer Therapeutics) and azstarys, a once-daily ADHD treatment marketed in the U.S. with Corium. The company is advancing arimoclomol for Niemann-Pick disease type C and engages with the FDA to navigate approvals. Zevra earns revenue from product sales, royalties, and milestone payments from its partnerships, and aims to build a differentiated portfolio that serves underserved patient populations.

Significant Headcount Growth

About Zevra Therapeutics

Simplify's Rating
Why Zevra Therapeutics is rated
B-
Rated B on Competitive Edge
Rated B on Growth Potential
Rated C on Differentiation

Industries

Biotechnology

Healthcare

Company Size

51-200

Company Stage

IPO

Headquarters

Boston, Massachusetts

Founded

2006

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Simplify's Take

What believers are saying

  • Q2 2026 revenue hit $39.7 million, up 53% year over year.
  • Cash reached $260.2 million June 30, 2026, after debt repayment and asset sale.
  • Q2 2026 prescription enrollment reached 184, with 69% covered-life access.

What critics are saying

  • EMA rejected arimoclomol in 2026; re-examination can still fail again.
  • MIPLYFFA drove $30.2 million of Q2 2026 revenue, creating single-product dependence.
  • If Europe stays closed, Zevra loses its biggest near-term expansion pathway.

What makes Zevra Therapeutics unique

  • MIPLYFFA won FDA approval September 20, 2024, for Niemann-Pick disease type C.
  • Zevra owns orphan and Orange Book protection for MIPLYFFA through 2041.
  • The 270-patient NPC dataset gives Zevra unmatched long-term real-world evidence.

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Funding

Total Funding

$291.8M

Above

Industry Average

Funded Over

9 Rounds

Post IPO Equity funding comparison data is currently unavailable. We're working to provide this information soon!
Post IPO Equity Funding Comparison
Coming Soon

Benefits

Wellness Program

Remote Work Options

Stock Price

Growth & Insights and Company News

Headcount

6 month growth

↑ 2%

1 year growth

↑ 8%

2 year growth

↑ 0%
MarketBeat
Aug 24th, 2026
Globeflex Capital L P invests $2.75 million in Zevra Therapeutics, Inc. $ZVRA.

Globeflex Capital L P invests $2.75 million in Zevra Therapeutics, Inc. $ZVRA. August 24, 2026 Key points. * Globeflex Capital initiated a $2.75 million position in Zevra Therapeutics, purchasing 191,904 shares, while institutional investors collectively own 35.03% of the company. * Zevra reported quarterly earnings of $0.25 per share, beating estimates of $0.11, and revenue of $39.66 million versus the $33.88 million consensus forecast. * Analysts maintain a favorable outlook, with nine Buy ratings and one Hold; the consensus rating is "Moderate Buy" with an average price target of $27.14, compared with the stock's reported $11.87 price. * Five stocks we like better than Zevra Therapeutics. Globeflex Capital L P bought a new position in shares of Zevra Therapeutics, Inc. (NASDAQ:ZVRA - Free Report) in the second quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission (SEC). The institutional investor bought 191,904 shares of the company's stock, valued at approximately $2,752,000. Globeflex Capital L P owned about 0.32% of Zevra Therapeutics as of its most recent filing with the Securities and Exchange Commission (SEC). Other institutional investors also recently bought and sold shares of the company. AIGH Capital Management LLC bought a new position in shares of Zevra Therapeutics during the 1st quarter valued at about $11,184,000. Dimensional Fund Advisors LP increased its holdings in shares of Zevra Therapeutics by 259.2% in the first quarter. Dimensional Fund Advisors LP now owns 554,802 shares of the company's stock worth $5,168,000 after purchasing an additional 400,336 shares during the last quarter. Hennion & Walsh Asset Management Inc. increased its holdings in shares of Zevra Therapeutics by 116.6% in the second quarter. Hennion & Walsh Asset Management Inc. now owns 383,706 shares of the company's stock worth $5,502,000 after purchasing an additional 206,543 shares during the last quarter. UBS Group AG lifted its position in shares of Zevra Therapeutics by 30.9% in the fourth quarter. UBS Group AG now owns 285,488 shares of the company's stock worth $2,558,000 after buying an additional 67,392 shares in the last quarter. Finally, Janney Montgomery Scott LLC lifted its position in shares of Zevra Therapeutics by 16.7% in the first quarter. Janney Montgomery Scott LLC now owns 236,834 shares of the company's stock worth $2,207,000 after buying an additional 33,951 shares in the last quarter. 35.03% of the stock is owned by hedge funds and other institutional investors. Zevra Therapeutics stock performance. Shares of Zevra Therapeutics stock opened at $11.87 on Monday. The stock has a market cap of $704.84 million, a price-to-earnings ratio of 12.90 and a beta of 0.91. The stock has a 50 day moving average price of $12.23 and a 200-day moving average price of $10.77. Zevra Therapeutics, Inc. has a one year low of $7.16 and a one year high of $15.03. Zevra Therapeutics (NASDAQ:ZVRA - Get Free Report) last released its quarterly earnings results on Wednesday, August 5th. The company reported $0.25 earnings per share for the quarter, beating the consensus estimate of $0.11 by $0.14. The company had revenue of $39.66 million for the quarter, compared to analyst estimates of $33.88 million. Zevra Therapeutics had a return on equity of 54.54% and a net margin of 42.82%. Sell-side analysts predict that Zevra Therapeutics, Inc. will post 0.72 earnings per share for the current fiscal year. Insiders place their bets. In other news, Director Corey Michael Watton sold 12,300 shares of the stock in a transaction on Monday, August 10th. The shares were sold at an average price of $11.25, for a total value of $138,375.00. Following the sale, the director owned 1,800 shares of the company's stock, valued at approximately $20,250. This represents a 87.23% decrease in their ownership of the stock. The sale was disclosed in a legal filing with the SEC, which can be accessed through this link. 3.70% of the stock is owned by company insiders. Analyst upgrades and downgrades. Several equities analysts have weighed in on ZVRA shares. Citizens Jmp raised their price target on Zevra Therapeutics from $25.00 to $28.00 and gave the company a "market outperform" rating in a report on Thursday, August 6th. Canaccord Genuity Group decreased their price objective on Zevra Therapeutics from $29.00 to $20.00 and set a "buy" rating on the stock in a report on Monday, July 27th. Maxim Group increased their target price on Zevra Therapeutics from $25.00 to $35.00 and gave the company a "buy" rating in a research report on Wednesday, June 10th. Citigroup reissued an "outperform" rating on shares of Zevra Therapeutics in a report on Thursday, August 6th. Finally, Guggenheim decreased their price target on shares of Zevra Therapeutics from $24.00 to $23.00 and set a "buy" rating on the stock in a research note on Friday, August 7th. Nine analysts have rated the stock with a Buy rating and one has assigned a Hold rating to the company. Based on data from MarketBeat, the company has a consensus rating of "Moderate Buy" and an average price target of $27.14. Discover more Space Stocks Report Dividend Screener Tool About Zevra Therapeutics. Zevra Therapeutics, Inc discovers and develops various proprietary prodrugs to treat serious medical conditions in the United States. The company develops its products through Ligand Activated Therapy platform. Its lead product candidate is KP1077, consisting of KP1077IH, which is under Phase 2 clinical trial for the treatment of idiopathic hypersomnia, and KP1077N, which is under Phase 1/2 clinical trial to treat narcolepsy. The company is also developing Celiprolol, a prodrug product candidate that is under Phase 1/2 clinical trial for the treatment of vascular Ehlers Danlos syndrome. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Continue following MarketBeat Before you consider Zevra Therapeutics, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Zevra Therapeutics wasn't on the list. While Zevra Therapeutics currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys. The AI boom is creating opportunities across semiconductors, cloud computing, enterprise software, infrastructure, cybersecurity, and automation. Inside this report, you'll find 10 companies positioned to benefit as artificial intelligence moves from hype to real-world deployment and becomes a core growth driver for corporate America.

Yahoo Finance
Aug 7th, 2026
Zevra publishes first real-world NPC data as it seeks EMA re-examination after negative opinion

Zevra Therapeutics published long-term real-world safety and effectiveness data for arimoclomol in adults with Niemann-Pick disease type C. This marks the first extensive evaluation of arimoclomol outside clinical trials. The company is pursuing regulatory options in Europe following a negative opinion from the European Medicines Agency on arimoclomol. Zevra has requested a re-examination of its Marketing Authorization Application. The stock has been volatile, gaining 23.2% over the past week but declining 17.7% over the past month. Year-to-date returns stand at 42.4%, with the stock last closing at $11.88. Latest quarterly results showed net income of $8.75 million on sales of $39.66 million. The European regulatory review adds timing risk and uncertainty for investors.

Yahoo Finance
Aug 6th, 2026
Zevra Therapeutics revenue surges 53% to $39.7M as MIPLYFFA US sales hit $30.2M in Q2 2026

Zevra Therapeutics reported total net revenue of $39.7 million in Q2 2026, marking a 53% increase year-over-year. The company's US sales of MIPLYFFA reached $30.2 million, up 23% sequentially and 40% year-over-year. Operating expenses decreased to $21.0 million, down $3.2 million from the previous year. The company posted net income of $8.8 million, or $0.14 per share. Cash and investments stood at $260.2 million as of 30 June 2026, up $23.4 million from the previous quarter. Since launch, MIPLYFFA has received 184 prescription enrolment forms, with 14 added in Q2. Zevra strengthened its intellectual property position for MIPLYFFA with Orange Book protection through 2041. The company continues advancing its pipeline, including the Phase III DISCOVER trial for celiprolol.

WTOP
Aug 5th, 2026
Zevra Therapeutics: Q2 earnings snapshot.

Zevra Therapeutics: Q2 earnings snapshot. August 5, 2026, 5:18 PM BOSTON (AP) - BOSTON (AP) - Zevra Therapeutics, Inc. (ZVRA) on Wednesday reported second-quarter earnings of $8.8 million. The Boston-based company said it had net income of 14 cents per share. Earnings, adjusted for non-recurring costs, were 25 cents per share. The results surpassed Wall Street expectations. The average estimate of three analysts surveyed by Zacks Investment Research was for earnings of 8 cents per share. The specialty pharmaceutical company posted revenue of $39.7 million in the period, which also beat Street forecasts. Three analysts surveyed by Zacks expected $32.3 million. Keep Watching Kent Island restaurant adds a million new oysters to Chesapeake Bay Kent Island restaurant adds a million new oysters to Chesapeake Bay This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on ZVRA at https://www.zacks.com/ap/ZVRA

MarketBeat
Jul 29th, 2026
Zevra Therapeutics (ZVRA) expected to announce quarterly earnings on Wednesday.

Zevra Therapeutics (ZVRA) expected to announce quarterly earnings on Wednesday. July 29, 2026 Key points. * Zevra Therapeutics is expected to report Q2 2026 results after the market closes on August 5. Analysts forecast earnings of $0.08 per share and revenue of approximately $33.9 million. * In its prior quarter, Zevra exceeded expectations, reporting EPS of $0.18 versus the $0.06 consensus and revenue of $36.22 million versus $31.96 million expected. * The stock recently traded at $9.55, down 1.8%, while analysts maintain a "Moderate Buy" consensus and an average price target of $26.86. * MarketBeat previews the top five stocks to own by August 1st. Zevra Therapeutics (NASDAQ:ZVRA - Get Free Report) will likely be issuing its Q2 2026 results after the market closes on Wednesday, August 5th. Analysts expect the company to post earnings of $0.08 per share and revenue of $33.8830 million for the quarter. Individuals may visit the the company's upcoming Q2 2026 earning overview page for the latest details on the call scheduled for Wednesday, August 5, 2026 at 4:30 PM ET. Zevra Therapeutics (NASDAQ:ZVRA - Get Free Report) last posted its earnings results on Wednesday, May 6th. The company reported $0.18 earnings per share (EPS) for the quarter, topping the consensus estimate of $0.06 by $0.12. The firm had revenue of $36.22 million for the quarter, compared to the consensus estimate of $31.96 million. Zevra Therapeutics had a return on equity of 51.49% and a net margin of 101.58%. On average, analysts expect Zevra Therapeutics to post $1 EPS for the current fiscal year and $1 EPS for the next fiscal year. Zevra Therapeutics trading down 1.8%. Shares of NASDAQ ZVRA traded down $0.18 during mid-day trading on Wednesday, hitting $9.55. The company had a trading volume of 214,486 shares, compared to its average volume of 1,355,924. Zevra Therapeutics has a 1 year low of $7.16 and a 1 year high of $15.03. The company has a market capitalization of $564.66 million, a price-to-earnings ratio of 4.79 and a beta of 0.85. The stock's 50-day moving average price is $12.35 and its 200-day moving average price is $10.50. Wall Street analyst weigh in. Several research analysts have commented on the company. Guggenheim cut their target price on Zevra Therapeutics from $29.00 to $24.00 and set a "buy" rating for the company in a research note on Monday. Weiss Ratings downgraded shares of Zevra Therapeutics from a "buy (b-)" rating to a "hold (c)" rating in a report on Friday, May 22nd. HC Wainwright restated a "buy" rating and issued a $26.00 price objective on shares of Zevra Therapeutics in a research report on Tuesday, June 23rd. Wall Street Zen raised shares of Zevra Therapeutics from a "hold" rating to a "buy" rating in a research note on Sunday, July 12th. Finally, Citigroup reissued an "outperform" rating on shares of Zevra Therapeutics in a report on Tuesday, June 9th. Nine research analysts have rated the stock with a Buy rating and two have assigned a Hold rating to the company's stock. According to data from MarketBeat.com, the company currently has a consensus rating of "Moderate Buy" and an average price target of $26.86. Institutional trading of Zevra Therapeutics. Several institutional investors and hedge funds have recently modified their holdings of ZVRA. Marshall Wace LLP bought a new stake in Zevra Therapeutics in the 3rd quarter valued at $8,676,000. Rubric Capital Management LP increased its holdings in shares of Zevra Therapeutics by 60.8% in the second quarter. Rubric Capital Management LP now owns 1,958,318 shares of the company's stock worth $17,253,000 after purchasing an additional 740,584 shares during the last quarter. Adage Capital Partners GP L.L.C. lifted its position in shares of Zevra Therapeutics by 15.2% in the second quarter. Adage Capital Partners GP L.L.C. now owns 4,168,000 shares of the company's stock worth $36,720,000 after buying an additional 550,000 shares in the last quarter. Nantahala Capital Management LLC boosted its stake in Zevra Therapeutics by 34.0% during the third quarter. Nantahala Capital Management LLC now owns 1,971,936 shares of the company's stock valued at $18,753,000 after buying an additional 500,000 shares during the last quarter. Finally, Algert Global LLC purchased a new position in Zevra Therapeutics during the 3rd quarter valued at approximately $3,980,000. 35.03% of the stock is currently owned by institutional investors. About Zevra Therapeutics. Zevra Therapeutics, Inc discovers and develops various proprietary prodrugs to treat serious medical conditions in the United States. The company develops its products through Ligand Activated Therapy platform. Its lead product candidate is KP1077, consisting of KP1077IH, which is under Phase 2 clinical trial for the treatment of idiopathic hypersomnia, and KP1077N, which is under Phase 1/2 clinical trial to treat narcolepsy. The company is also developing Celiprolol, a prodrug product candidate that is under Phase 1/2 clinical trial for the treatment of vascular Ehlers Danlos syndrome. This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to [email protected]. Before you consider Zevra Therapeutics, you'll want to hear this. MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Zevra Therapeutics wasn't on the list. While Zevra Therapeutics currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys. The AI boom extends far beyond the biggest tech names. Discover 10 companies supplying the memory, storage, networking, semiconductor manufacturing, and power infrastructure that make AI possible. Learn where the next wave of AI investment opportunities may emerge - and the key risks investors should watch as the global AI buildout accelerates.

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