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Jazz Pharmaceuticals

Biopharmaceuticals focused on neuroscience and oncology

Associate Director – AI Development Lead

Full-Time
$153.6k - $230.4k
Senior, Expert
Bachelor's
Massachusetts, USA
Remote
AI & Machine LearningApplied Machine Learning

About the job

Requirements
  • Demonstrated ability to lead, mentor, and be accountable for the technical work of others.
  • Demonstrated experience leading offshore or nearshore development teams.
  • Hands-on technical depth in building and shipping machine learning and generative AI solutions to production.
  • Proficiency in writing production-quality code and designing AI/ML architecture.
  • Strong understanding of core machine learning algorithms, statistical modeling techniques, model evaluation, and real-world deployment considerations.
  • Proficiency in one or more programming languages, such as Python or R, and machine learning frameworks such as TensorFlow, PyTorch, or scikit-learn.
  • Strong understanding of modern generative AI concepts and approaches, including large language models, retrieval-augmented generation, fine-tuning, agentic patterns, evaluation, and guardrails.
  • Significant hands-on experience with at least one major cloud platform: AWS, GCP, or Azure.
  • Familiarity with AI governance and risk frameworks.
  • Bachelor’s degree or equivalent practical experience in a quantitative or technical field.
  • Five to seven years of relevant experience in AI, machine learning, or data science.
  • Ability to explain complex technical concepts in clear, non-technical terms, and to influence and guide stakeholders across organizational levels.
Responsibilities
  • Build and ship end-to-end machine learning solutions, including data ingestion, feature engineering, model training, evaluation, deployment, and monitoring, across supervised, unsupervised, and other classical or statistical learning paradigms.
  • Design and ship end-to-end generative AI solutions, including retrieval-augmented generation systems, agentic workflows, vector stores, and integrations with foundation model APIs.
  • Write production-quality code across generative AI and AI/ML, with attention to readability, modularity, scalability, performance, and maintainability.
  • Design and review secure, reusable, and rigorous architectures across generative AI and AI/ML solutions, working with the Enterprise AI Architect to follow architectural standards.
  • Debug, profile, and optimize solutions, including cost, latency, accuracy, and reliability trade-offs.
  • Support deployment and post-deployment operations, including CI/CD, observability, model monitoring, drift detection, and incident response.
  • Establish and continuously refine technical development standards, including reference architectures, design patterns, coding conventions, evaluation methodologies, and reusable components.
  • Lead a small team of AI developers across traditional machine learning and generative AI, setting technical direction, priorities, and quality expectations.
  • Be accountable for the quality and outcomes of the team's work, including solution design, code and model quality, documentation, and delivery.
  • Mentor team members through formal and informal code and design review feedback, building technical depth and ownership across the team.
  • Plan and sequence delivery work with stakeholders, balancing scope, technical risk, and timelines.
  • Help recruit, onboard, and grow AI talent as the team expands.
  • Advise teams across Jazz, including non-technical teams, on how AI works, human-in-the-loop review, adoption optimization, and responsible and ethical use.
  • Evaluate AI use cases and proposed solutions for technical feasibility, data readiness, value, and risk.
  • Support business prioritization of AI initiatives based on business impact, technical feasibility, bandwidth constraints, solution complexity, and scalability; decide team resource allocation and development activities within agreed product priorities.
  • Vet AI vendors and platforms with the Enterprise AI Architect, Infrastructure, and Digital Security teams, conducting technical due diligence on feasibility, data handling, security, transparency, operational maturity, solution fit, practicality, and vendor understanding of AI capabilities and limitations.
  • Support build-versus-buy decisions with consideration of time-to-value, total cost of ownership, extensibility, and vendor risk.
  • Partner with the Director, Enterprise AI and VP of Data, AI, and Research to shape and execute enterprise AI strategy, including operating model, governance, technology stack, best practices, and policies.
  • Contribute to AI capability maturity through reference architectures, MLOps practices, evaluation frameworks, and reusable components that make future delivery faster and more reliable.
  • Help define and apply Responsible AI practices, including explainability, evaluation, privacy, security, and risk management, across team work.
  • Collaborate with Data Engineering, Enterprise Architecture, Infrastructure, InfoSec, and Compliance to ensure AI solutions meet enterprise standards.
  • Build credibility with senior technical and business stakeholders through communication and subject-matter expertise.
Desired Qualifications
  • Advanced degree or equivalent practical experience.
  • Ten or more years of relevant experience in AI, machine learning, or data science.
  • Experience in pharmaceuticals, life sciences, or another regulated industry.
  • Experience evaluating and integrating third-party AI/ML solutions and vendor platforms.
  • Experience with AWS or GCP.

About the company

Jazz Pharmaceuticals develops and markets therapies in neuroscience and oncology. Its products include Xyrem and the lower-sodium option Xywav for narcolepsy, Epidiolex for seizures in severe epilepsy, and oncology medicines Zepzelca for small cell lung cancer and Vyxeos for AML, with Epidiolex being cannabidiol-based. The company grows its portfolio through a mix of in-house R&D and strategic acquisitions that broaden its specialty-drug lineup and global reach. Its goal is to expand approved treatments and the pipeline to help patients with limited options by building a diversified, specialty-focused portfolio.

Company Size

1,001-5,000

Company Stage

IPO

Headquarters

Dublin, Ireland

Founded

2003

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Simplify's Take

What believers are saying

  • Q2 2026 revenue hit $1.21 billion; Jazz raised full-year guidance to $4.68 billion.
  • Actio's ABS-1230 adds first-in-class KCNT1 epilepsy upside after the September 15, 2026 close.
  • Oncology revenue exceeded $1 billion in 2025, driven by Zepzelca and Ziihera.

What critics are saying

  • Xywav faces Lupin, Teva, and Tris patent fights; generic entry threatens 2027 cash flow.
  • Xywav and EPIDIOLEX still dominate value; one patent loss or safety issue would crush earnings.
  • Jazz paid $820 million for Actio before registrational proof; ABS-1230 can still fail.

What makes Jazz Pharmaceuticals unique

  • Ziihera launched August 2026, targeting $3B-$5B across HER2-positive tumors.
  • EPIDIOLEX holds exclusivity into the late 2030s and now funds four new trials.
  • Xywav's low-sodium oxybate formulation keeps narcolepsy patients despite generic Xyrem pressure.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k) Retirement Plan

Paid Vacation

Growth & Insights and Company News

Headcount

6 month growth

0%

1 year growth

1%

2 year growth

0%
Yahoo Finance
Sep 20th, 2026
Jazz Pharma raises zanidatamab peak sales target to $3B-$5B as oncology revenue hits $1B

Jazz Pharmaceuticals reported its oncology revenue surpassed $1 billion in 2025, marking a 32% year-over-year increase. The growth follows three recent product launches, including zanidatamab, Modeyso and Zepzelca's FORTE regimen. The company raised zanidatamab's estimated peak-sales opportunity to $3 billion-$5 billion. Jazz aims to increase HER2-directed treatment adoption in gastroesophageal cancer, where only 60% of eligible HER2-positive patients currently receive such therapy. Jazz estimates the US incidence of HER2-positive gastroesophageal adenocarcinoma at approximately 8,000 patients, with a labelled population of 3,000 to 4,000 patients. The company is also developing zanidatamab for biliary tract cancer, colorectal cancer, non-small cell lung cancer and breast cancer. Jazz maintains commercial investment whilst preserving financial flexibility for acquisitions across oncology, epilepsy and sleep disorders.

Yahoo Finance
Sep 11th, 2026
Jazz Pharmaceuticals stock climbs 29.7% but analysts warn of declining margins and weak returns

Jazz Pharmaceuticals' stock has risen 29.7% over the past six months, outpacing the S&P 500 by 17 percentage points to reach $240.49 per share. However, analysts point to concerning trends in the company's fundamentals. The company's adjusted operating margin has declined by 2.6 percentage points over five years, despite revenue growth that should have improved economies of scale. Its trailing 12-month adjusted operating margin stood at 41.7%. Additionally, Jazz Pharmaceuticals' five-year average return on invested capital was just 2.7%, below the typical cost of capital for healthcare companies. This suggests mediocre efficiency in deploying capital for growth. The stock currently trades at 9.6× forward price-to-earnings ratio. Analysts consider this valuation reasonable but believe the company's weakening fundamentals present downside risk.

StockTitan
Aug 27th, 2026
Jazz Pharmaceuticals prices upsized $1.1B exchangeable notes offering with $225M share repurchase

Jazz Pharmaceuticals has priced an upsized $1.1 billion private offering of 1.875% exchangeable senior notes due 2032, up from the previously announced $1.0 billion. The offering, conducted through its wholly-owned subsidiary Jazz Investments I Limited, is expected to close on 31 August 2026. The notes will mature on 15 September 2032 and are exchangeable at an initial rate of 2.8150 ordinary shares per $1,000 principal amount, equivalent to an exchange price of approximately $355.24 per share. This represents a 42.5% premium above the last reported sale price on 26 August 2026. The company will use net proceeds of approximately $1,079 million for general corporate purposes. Concurrently, Jazz Pharmaceuticals agreed to repurchase approximately $225 million of its ordinary shares from note purchasers at $249.29 per share, using existing cash on hand.

Yahoo Finance
Aug 26th, 2026
Jazz Pharmaceuticals launches Ziihera for HER2-positive cancer with $3B–$5B peak sales outlook

Jazz Pharmaceuticals has launched Ziihera in the US following FDA approval for first-line treatment of HER2-positive, unresectable or metastatic gastroesophageal adenocarcinoma. The drug can be used with tislelizumab and chemotherapy, or with chemotherapy alone for certain patients. In the Phase III HERIZON-GEA-01 trial, Ziihera-based regimens reduced the risk of disease progression or death by 35%. The triplet regimen extended median overall survival to 26.4 months, a 28% reduction in death risk versus trastuzumab. Jazz estimates the US addressable market at 3,000–4,000 patients annually and raised Ziihera's peak sales outlook to $3 billion–$5 billion. The company plans to leverage existing commercial infrastructure whilst pursuing additional cancer indications and international regulatory filings.

Yahoo Finance
Aug 11th, 2026
Jazz Pharmaceuticals Q2 revenue beats estimates at $1.21B, ups guidance to $4.68B

Jazz Pharmaceuticals reported a strong second quarter with revenue of $1.21 billion, beating analyst estimates of $1.12 billion and representing 15.5% year-on-year growth. The company raised its full-year revenue guidance to $4.68 billion from $4.38 billion. CEO Renée Galá attributed the performance to strong demand for flagship products like Xywav and Epidiolex, alongside accelerating uptake of new oncology therapies. Operating margin improved to 20.5%, up from negative 65.6% in the prior year quarter. However, adjusted earnings per share of $5.71 missed analyst expectations of $6.18. During the earnings call, analysts focused on Epidiolex's growth drivers, Xywav's sustainability amid potential generic competition, and zanidatamab's upcoming approval prospects.