Experienced Scientist - Proteomics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world.  We provide an inclusive work environment where each person is considered as an individual.  At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for an Experienced Scientist, Proteomics to be located in Cambridge, MA.

Purpose: Do you want to use your hard-earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis.

Be part of a motivated team deploying cutting-edge mass spectrometry technologies to tackle challenges in end-to-end drug discovery and development. Work across a leading multiomics organization to provide coordinated insights across a variety of 'omics layers.

This is a hands-on laboratory role, fit for a scientist who thrives at the bench and wants to grow in experimental design and scientific communication by working closely with senior scientists. With your help, we will drive development of medicines for our patients!

You will be responsible for:

• Joining a team of wet lab scientists enabling proteomic impact across a wide variety of programs and therapeutic modalities.
• Planning and performing wet lab proteomic activities supporting evaluation of therapeutic candidates.
• Generating samples for proteomics analysis from multiple sources (immortalized cell lines, FFPE, fresh-frozen tissue, plasma/serum, etc.).
• Maintaining multiple cell lines in both flasks and plates. Preparing assay plates and performing chemical treatments and perturbations.
• Applying high-efficiency proteomics sample preparation methodologies across many experiment types (global proteomic profiling, immunoprecipitation, affinity, PTM analysis).
• Operating and maintaining LC-MS instrumentation (Thermo Orbitrap Exploris/Eclipse/Astral, Bruker timsTOF; LC systems such as Vanquish Neo, Evosep One, UltiMate 3000), including daily/weekly maintenance, calibration, and troubleshooting.
• Deploying automation-supported workflows for high-throughput sample prep using platforms such as Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, or Dynamic Devices Lynx.
• Ensuring QC and reproducibility, including system suitability checks, performance tracking, and SOP documentation.
• Collaborating with colleagues within the proteomics group to drive proteomics experiments across the drug discovery portfolio.
• Demonstrating creativity and applying novel approaches to solving scientific problems. Proposing novel and practical ideas aligned with scientific strategies and demands.

Qualifications / Requirements

Education:

• A Master's degree with 1+ years, or a Bachelor's degree with 3+ years, of proven experience in a proteomics laboratory setting (in Analytical Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology, or a related field).

Experience and Skills:

Required:

• Minimum of 2 years of experience with mammalian cell culture and treatment.
• Experience with label-free proteomics workflows and robust sample preparation techniques.
• Strong planning and organizational skills with the ability to handle several projects at a time in a fast-paced environment.
• Excellent interpersonal skills working with diverse colleagues.

Preferred:

• Experience with liquid chromatography (Thermo Vanquish Neo, EASY-nLC, UltiMate 3000, or Evosep One) and mass spectrometry (Thermo Exploris, Eclipse, Lumos, Astral, or Bruker timsTOF) instrumentation.
• Experience with data processing suites such as Proteome Discoverer, MaxQuant, DIA-NN, Spectronaut, or Skyline.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.

#LI-Onsite

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is :

$94,000.00 - $151,800.00

Additional Description for Pay Transparency:

ubject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).



This position is eligible to participate in the Company’s long-term incentive program.



Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:

Vacation –120 hours per calendar year

Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year

Holiday pay, including Floating Holidays –13 days per calendar year

Work, Personal and Family Time - up to 40 hours per calendar year

Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child

Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year

Caregiver Leave – 80 hours in a 52-week rolling period10 days

Volunteer Leave – 32 hours per calendar year

Military Spouse Time-Off – 80 hours per calendar year

For additional general information on Company benefits, please go to: https://www.careers.jnj.com/employee-benefits