Medical Science Manager Leader - Bc
About the job
- A major in clinical medicine, pharma, or science.
- More than five years of work experience in medical affairs or relevant functions in a pharmaceutical company.
- More than three years of people-management experience is preferred.
- Strategic thinking and planning skills.
- Demonstrated ability in cross-functional leadership.
- Experience in people and budget management in relevant pharmaceutical organizations.
- Expertise in the relevant therapeutic area and an established TAE network.
- A track record of delivering high-quality work within timelines.
- Ability to think strategically and align with a wide range of stakeholders.
- Ability to motivate team members toward shared goals.
- Ability to work proactively in changing and complex circumstances.
- Lead the Medical Science Manager team as field-based medical experts in the assigned disease area and develop and execute the territory medical plan in alignment with the disease-area medical strategy.
- Strengthen field TAE management by building and continuously improving the Medical Science Manager disease-area team's capability and capacity to ensure high-quality scientific engagement.
- Mentor Medical Science Managers for career development.
- Enhance collaboration between the Medical Science Manager team and cross-functional stakeholders.
- Contribute to global innovative initiatives and lead their implementation in China for the assigned disease area.
- Lead cross-functional projects as a medical expert.
- Ensure strict medical compliance in Medical Science Manager activities.
- Ensure execution of the team's medical plan and alignment with the medical strategy.
- Ensure Medical Science Managers serve as primary contacts for data-generation activities, including investigator-initiated studies and research request management, study support, site assessment, and investigator engagement.
- Lead the team in designing and delivering scientific communication activities.
- Oversee scientific projects that address regional data gaps.
- Review and modify territory medical plans during implementation to support key medical initiatives.
- Shape the Medical Science Manager team's portfolio strategy in alignment with lifecycle and other strategic plans, and deliver medical plans in the assigned disease area.
- Integrate feedback from external customers and internal stakeholders for continuous improvement.
- Control the team's activity budgets and timelines through active tracking and recording.
- Lead the team's review and update of the target audience expert list through identification, profiling, and mapping.
- Define target audience expert management strategy and engagement plans in consultation with medical managers and business counterparts to support medical and brand strategy.
- Recruit a high-standard Medical Science Manager team.
- Design and conduct ongoing training on knowledge updates and soft-skill improvement.
- Assess assigned team members to ensure competency and effectiveness toward team and individual goals.
- Conduct regular joint visits to target audience experts with team members to ensure engagement quality.
- Contribute to global initiatives involving innovative customer engagement channels or team competency development, and lead exploration and implementation in China.
- Motivate the team and support subordinate Medical Science Managers' performance and career development.
- Oversee the development and implementation of training plans for the team.
- Manage the team's budget, including review and approval of expense reports.
- Support the Disease Area Head with performance management, evaluation, and organizational talent review for the team; initiate and lead relevant cross-disease-area management projects.
- Lead and manage internal and external change affecting cross-disease-area performance.
- Lead cross-functional collaboration with internal and external stakeholders in complex and ambiguous situations.
- Ensure high-quality medical and scientific support for commercial activities, including medical input into marketing strategy and sales training.
- Ensure all medical initiatives comply with Roche standard operating procedures, codes, and local regulations.
- Champion medical compliance with high ethics and integrity.
- Direct adoption of appropriate policies and standards for all Medical Science Manager activities.
- A master's degree or higher.
- More than three years of people-management experience.
About the company
Roche is a global leader in pharmaceuticals and diagnostics. It develops medicines and diagnostic tools that help detect, monitor, and treat diseases, using research and biotechnology to drive new therapies and tests. Roche combines drug development with in-house diagnostic products to support personalized medicine, where treatments are tailored to individual patients based on test results. Its approach differs from many peers by integrating drug discovery with diagnostic capabilities and by expanding its research through strategic acquisitions (like Genentech) to strengthen its biotechnology and R&D capabilities. The company’s goal is to improve patient outcomes and healthcare worldwide by delivering reliable medicines, accurate diagnostic tests, and data-driven care.
Company Size
1-10
Company Stage
IPO
Headquarters
Basel, Switzerland
Founded
1896
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Simplify's Take
What believers are saying
- Enicepatide delivered 15.5% weight loss in September 2026 and 22.7% in June.
- pTau217 can scale immediately through Roche's existing lab network and improve Alzheimer diagnostics.
- Roche's June 2026 data and September 2026 filings signal multiple obesity shots on goal.
What critics are saying
- Eli Lilly and Novo Nordisk dominate obesity pricing, distribution, and physician mindshare today.
- Enicepatide remains Phase II-only; Roche starts late-stage glycemic and cardiovascular studies in 2027.
- If enicepatide disappoints, Roche burns its $2.7 billion Carmot bet and loses obesity credibility.
What makes Roche unique
- Roche combines pharma, diagnostics, and installed cobas labs across 4,500 U.S. instruments.
- Elecsys pTau217 won FDA clearance on August 24, 2026, and CE marking September 7.
- Roche controls obesity assets from Carmot and Zealand, spanning GLP-1/GIP and amylin.
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Benefits
Performance Bonus
Company News
The US Food and Drug Administration has approved Roche's Tecentriq in combination with a fluoropyrimidine and oxaliplatin for adjuvant treatment of stage III deficient DNA mismatch repair colon cancer. This marks Tecentriq's twelfth approved indication in the US. The approval follows the phase III ATOMIC study, published in The New England Journal of Medicine, which demonstrated that Tecentriq plus chemotherapy reduced the risk of disease recurrence or death by 50% compared to chemotherapy alone. The 36-month disease-free survival rate was 86% with the combination versus 76% with chemotherapy alone. Nearly 25% of colon cancers are diagnosed at stage III, and almost one in three stage III patients experience recurrence within five years. This represents the first approved adjuvant immunotherapy regimen for this patient population. Roche is pursuing further regulatory filings, including with the European Medicines Agency.
Roche posted strong Phase 2 results for its weight loss drug enicepatide, showing 22.5% mean weight loss over 48 weeks. This compares favourably to Eli Lilly's Zepbound, which achieved 20.2% weight loss over 72 weeks in a separate trial. In another Phase 2 study, enicepatide demonstrated HbA1c reductions of up to 2.65 percentage points in diabetic patients after 48 weeks, compared to tirzepatide's 2.37 percentage points after 52 weeks. Despite promising results, Roche faces stiff competition from Novo Nordisk and Eli Lilly, which both have deep pipelines in development. Novo Nordisk's CagriSema is nearing approval, whilst Eli Lilly's retatrutide has posted strong Phase 3 results. Roche's revenue grew 6% year over year in the first half of the year to 30.4 billion Swiss francs.
Roche has launched a newborn screening test that simultaneously detects three severe genetic conditions: Spinal Muscular Atrophy, Severe Combined Immunodeficiency Disease, and Sickle Cell Disease. TIB MOLBIOL, a Roche subsidiary, developed the LightMix Newborn TREC/SMN1/HBB kit for use in countries accepting the CE mark. The test enables early detection before symptoms appear, allowing clinicians to initiate life-changing treatments sooner. Early intervention can prevent severe nerve damage in SMA, enable lifesaving bone marrow transplants for SCID, and drastically lower infant mortality in SCD through preventive measures. The IVDR-approved test provides a ready-to-use solution that integrates into existing laboratory workflows. It runs on established LightCycler systems, making it accessible for private and academic hospital laboratories across Europe.
Roche's collaborator MediLink has announced positive phase III results for tambotatug pelitecan (Tam-Peli) in Chinese patients with relapsed small-cell lung cancer. The TAISHAN-302 trial showed Tam-Peli reduced the risk of death by 54% compared to topotecan, with median overall survival of 13.3 versus 9.4 months. The antibody-drug conjugate also demonstrated superior progression-free survival (7.4 versus 2.8 months) and objective response rates (59.1% versus 9.7%). China's National Medical Products Administration has accepted the New Drug Application for filing. Roche is developing and commercialising Tam-Peli outside mainland China, Hong Kong and Macau, with plans to rapidly initiate global trials. The therapy has received Breakthrough Therapy Designations from both the US FDA and China CDE for relapsed small-cell lung cancer.
Tempus AI has raised $600 million in Series C funding to scale its machine learning platform for cancer recurrence detection through liquid biopsies. The investment was led by SoftBank Vision Fund 2, with participation from Roche and Merck. Phase II trial data showed the AI-enhanced liquid biopsy analysis reduced false-negative results by 37% compared to conventional methods. The platform uses deep learning algorithms trained on over 12,000 genomic profiles to identify circulating tumour DNA fragments shed by residual cancer cells. A 2025 Nature Medicine study reported the system achieved 92% specificity in detecting minimal residual disease across breast, lung, and colorectal cancers. According to SEC filings, 45% of funds will support FDA pre-market approval trials, whilst 30% will fund global expansion into EU and APAC markets.