Pattern Biosciences

Rapid bacterial ID and susceptibility testing

In vivo Research Associate - Oncology

Translational Research & Bench BiologyConfirmed live in the last 24 hours

Full-timeSouth San Francisco, CA, USANo salary listedIn-person

About the Job

Requirements

A Master of Science in life sciences is required.
At least 3 years of hands-on experience working with murine oncology models in an academic or industry setting is required.
Strong hands-on experience with complex rodent procedures, such as thoracic or abdominal surgery, suturing and wound closure, and tail vein dosing, is required.
Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation, and flow cytometry is required.
Strong organizational and record-keeping skills are required.
The ability to collaborate effectively in a cross-functional team is required.

Responsibilities

Plan and execute in vivo studies in collaboration with discovery and data scientists.
Perform in vivo procedures in mice, including intravenous, intraperitoneal, and subcutaneous dosing, blood sampling, and complex surgeries to establish orthotopic tumor models via abdominal surgery.
Conduct routine animal health monitoring and recording, and monitor tumor volume by in vivo imaging or caliper measurement.
Perform necropsy, biological sample processing, tissue dissociation and cell sorting via magnetic-activated cell sorting or fluorescence-activated cell sorting, and downstream analysis.
Conduct mammalian cell culture and quality control for in vivo experiments.
Generate, document, and analyze in vivo study data in accordance with study protocols, standard operating procedures, and regulatory guidelines.
Interface with external laboratories and partners.

Desired Qualifications

Experience working in a Good Laboratory Practice or regulatory-compliant environment is a plus.

You will perform in vivo studies of our AAV-based cancer therapeutic candidates to advance our oncology
pipeline and technology platform. You will contribute to the design of the preclinical studies and their
execution, ensuring high level of scientific rigor and compliance with relevant regulations. This is an ideal
position for a candidate with a strong background in vivo experiments who thrives in a team-oriented,
cross-disciplinary, and collaborative environment.

Primary Responsibilities

Plan and execute in vivo studies in collaboration with discovery and data scientists
Perform various in vivo procedures in mice: dosing via IV, IP and SC, blood sampling, and
complex surgeries to establish orthotopic tumor models via abdominal surgery
Conduct routine animal health monitoring and recording and monitor tumor volume by in vivo
imaging or caliper measurement
Perform necropsy, biological sample processing, tissue dissociation and cell sorting via MACS or
FACS, and downstream analysis
Conduct mammalian cell culture and QC for in vivo experiments
Generate, document and analyze in vivo study data in accordance with study protocols, SOPs,
and regulatory guidelines
Interface with external laboratories and partners

Required Skills & Qualifications

MSc in life sciences.
At least 3 years of hands-on experience working with murine oncology models in an academic or
industry setting.
Strong hands-on experience with complex rodent procedures, such as thoracic or abdominal
surgery, suturing and wound closure, and tail vein dosing
Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation,
and flow cytometry
Detail-oriented with strong organizational and record-keeping skills
Excellent communication skills and ability to collaborate effectively in a cross-functional team.
Experience working in a GLP or regulatory-compliant environment is a plus.

At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every step—from DNA constructs to AAV-based delivery systems—we are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives.

About the Company

Pattern Biosciences

Rapid bacterial ID and susceptibility testing

Pattern Biosciences develops an in-vitro diagnostics platform for rapid bacterial identification and antibiotic susceptibility testing. It combines single-cell analysis with machine learning; an instrument and proprietary test kits process a clinical sample to identify the pathogen and predict the most effective antibiotic within hours. Unlike traditional methods that take days, this approach speeds up actionable results and uses data from single cells plus ML, with revenue from instrument sales plus consumables. Its goal is to improve patient outcomes, reduce healthcare costs, and help preserve antibiotic effectiveness by enabling faster, more accurate treatment decisions.

Company size: 11-50
Company stage: Grant
Total funding: $60K
Headquarters: South San Francisco, CA
Founded: 2018

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