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Full-Time

Principal Scientist

In Vitro Pharmacology & Biomarkers

Confirmed live in the last 24 hours

Flagship Pioneering

Flagship Pioneering

501-1,000 employees

Biotechnology firm creating health and sustainability solutions

Biotechnology
Healthcare

Senior

Boston, MA, USA

Category
Lab & Research
Life Sciences
Requirements
  • PhD in molecular or cell biology or related discipline with minimum 6 years relevant experience in industry required
  • Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, and reporter cell lines
  • Proficient in industry-standard cell-based assay and bioanalytical techniques including TR-FRET, ELISA, flow cytometry, and reporter gene; experience with cellular/high content imaging and image analysis a plus
  • Experienced with primary cell culture and characterization, including tissue dissociation and cell isolation of various immune cell types
  • Experienced in biomarkers identification, assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
  • In vivo pharmacology expertise highly desired
  • Demonstrated ability to independently design, develop and optimize diverse cell-based assays and interpret complex results
  • Disease biology expertise in at least 2 of the following: immunology, oncology, metabolism and neuroscience
  • Proficiency in laboratory automation and semi-automated screening workflows a plus
  • Industry level experience with best practices related to data records creation and maintenance and workflows integrity
  • Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality
  • Demonstrated ability to lead and grow people in the industry setting
Responsibilities
  • Design, develop and execute cell-based assays to assess SynteinTM activity, target engagement and mechanism of action to drive discovery programs
  • Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas
  • Collaborate with the Discovery team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members
  • Contribute to in vivo and ex-vivo pharmacology activities to progress the projects and the platform
  • Collaborate cross-functionally to enable novel methods, assays and screening workflows
  • Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles
  • Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings

Flagship Pioneering fosters a culture of groundbreaking advancements in biotechnology, emphasizing an ecosystem approach that synergizes human health and sustainability. Their business model not only focuses on creating transformative products but also incubates leading companies like Moderna and Indigo Agriculture, positioning them at the forefront of scientific innovation and industry leadership. This approach offers employees a unique opportunity to be part of a pioneering team that drives real-world impacts across multiple sectors.

Company Stage

N/A

Total Funding

$6.4B

Headquarters

Cambridge, Massachusetts

Founded

2000

Simplify Jobs

Simplify's Take

What believers are saying

  • Flagship's recent $3.6 billion raise will support the creation of 25 new breakthrough companies, offering substantial growth opportunities.
  • The firm's track record of founding over 100 biotechnology companies, including industry leaders like Moderna, highlights its potential for high-impact innovation.
  • Key leadership appointments and promotions, such as Lovisa Afzelius to General Partner, strengthen Flagship's strategic direction and operational capabilities.

What critics are saying

  • The ambitious goal of creating 25 breakthrough companies may stretch resources and focus, potentially impacting the quality of each venture.
  • Heavy reliance on AI and advanced computational techniques could face technological and regulatory hurdles, slowing down progress.

What makes Flagship Pioneering unique

  • Flagship Pioneering's focus on creating and developing breakthrough companies in human health, sustainability, and AI sets it apart from traditional venture firms.
  • Their significant capital pool of $10.9 billion and $14 billion in assets under management provides unparalleled financial backing for innovative ventures.
  • Flagship's unique approach to leveraging generative AI for drug discovery and development accelerates the creation of transformative technologies.

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