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Sartorius

Bioprocess and laboratory solutions provider

Research Intern - Downstream Processing, Marlborough, MA

Bioprocess & BiomanufacturingConfirmed live in the last 24 hours
Internship · Summer 2026Marlborough, MA, USA$30 /hrIn-person

About the Job

Requirements

  • PhD candidate in Bioengineering, or closely related discipline with formal education and experience with extracellular vesicles characterization and purification
  • Hands-on experience with tangential flow filtration systems (lab or pilot scale) for nanoparticle or biologics concentration and diafiltration
  • Practical knowledge of chromatography techniques such as size exclusion chromatography, ion exchange, or affinity purification
  • Familiarity with nanoparticle systems such as extracellular vesicles, viral vectors (e.g., AAV, lentivirus), or lipid nanoparticles
  • Comfortable working in a wet lab environment with complex biological samples
  • Strong documentation and organizational skills; experience with SOPs and batch records is a plus

Responsibilities

  • Execute purification protocols: Perform purification of extracellular vesicles and viral vectors using tangential flow filtration systems (hollow fiber and/or flat sheet) and various chromatography modalities (e.g., ion exchange, size exclusion, affinity)
  • Optimize unit operations: Assist in the design and optimization of downstream steps to improve product yield, purity, and scalability
  • System operation and maintenance: Operate and maintain tangential flow filtration and chromatography systems (e.g., AKTA or equivalent), including setup, cleaning, and troubleshooting
  • Sample handling and quantification: Prepare and process samples following standard operating procedures. Quantify particles using orthogonal methods such as nanoparticle tracking analysis, quantitative polymerase chain reaction, protein assays, and total RNA analysis
  • Process monitoring and data recording: Monitor and document key parameters (e.g., transmembrane pressure, flux, recovery) during tangential flow filtration runs. Maintain detailed lab notebooks and process logs
  • Analytical support: Support integration of downstream data with analytical assays (e.g., flow cytometry, size-exclusion chromatography multi-angle light scattering, sodium dodecyl sulfate-polyacrylamide gel electrophoresis) for process characterization
  • Collaborative work: Interact regularly with upstream, analytical, and formulation teams to align on process goals and transfer knowledge
  • Safety and compliance: Follow laboratory safety protocols and ensure compliance with quality standards and experimental reproducibility

Desired Qualifications

  • Experience with analytical tools such as nanoparticle tracking analysis, Bradford protein assay, quantitative polymerase chain reaction, high-performance liquid chromatography, or size-exclusion chromatography multi-angle light scattering is highly desirable
  • Identification with Sartorius core values: Sustainability, Openness, Enjoyment

About the Company

Sartorius

Bioprocess and laboratory solutions provider

Sartorius provides laboratory and bioprocessing equipment and services for biopharmaceutical development and manufacturing. Its products cover end-to-end needs such as bioreactors, single-use technologies, filtration and purification tools, analytics, and lab instruments, enabling researchers to grow, purify, and test biologics. The company differentiates itself with a long history, a broad, integrated portfolio, global support, and strategic acquisitions that expand its services under one trusted partner. Its goal is to help biopharmaceutical companies develop and produce biotech drugs and vaccines reliably at scale.

Company size
1,001-5,000
Company stage
IPO
Headquarters
Göttingen, Germany
Founded
1870

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