Senior Manager, IT - Digital Plant Applications & Infrastructure

Life at BMS

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

Job Description 

The Sr. Manager, IT Digital Plant Applications & Infrastructure is an integral part of bringing RayzeBio’s innovative drug products to patients in need. In this role, you will report directly to the Exec. Director, IT and be primarily responsible implementing RayzeBio’s vision for growth and leading efforts to enable digital processes to achieve commercialization objectives at the site.  The role will ensure the digital systems applications along with CSV for lab and process automation are enabled and maintained to successfully deliver novel Radiopharmaceutical technologies.   You will work with lab & process automation, large corporate systems, small biotech systems, across all functions for the Whitestown site.  Additional responsibilities will include working with architectural and IT partners and specialty equipment manufacturers to achieve our technology and commercialization goals. 

Job Responsibilities 

• Responsible for continuous operation and maintenance of IT, data for lab & process automation systems (including MES, LIMS, local manufacturing, quality control and quality management site IT systems) as well as associated site infrastructure. 

• Key partner for Engineering and process automation space. 

• Deliver to site service level management scope and process with IT groups and/or vendor managed services, i.e. Service Level Agreements (SLA’s), Disaster Recovery/Service Continuity, etc. 

• Work with service providers to deliver effective, innovative and stable solutions that meet the needs of the site. 

• Support site regulatory inspection readiness and data integrity initiatives. 

• Partner on new demand from the various site functions (Manufacturing Operations, Quality, Supply Chain, Manufacturing Science & Technology)  

• Identify key technology trends and how new technologies might be leveraged to provide better solutions to the manufacturing site  

• Support deployment of long-term (3 year) roadmaps identifying capabilities that have the greatest impact on business capabilities for the organization.   Partnering and benchmarking with external sources. 

Education and Experience: 

• Bachelors in Engineering, IT, Science field or equivalent 

• 7-10+ years of IT experience in biotechnology, pharmaceutical, life sciences or GxP manufacturing.  Prior radiopharma experience is highly valued but not required. 

• Proven technical leadership and management experience. 

• Demonstrated experience implementing either automation and digitization projects. 

• BS/MS Information Technology or similar degree or equivalent experience 

Skills: 

• Ability to effectively communicate with both technical and non-technical team members.   

• Strong interpersonal skills, especially regarding:  

• Teamwork and collaboration  

• Client focus  

• Verbal and written communication   

• Knowledge of pharma IT Architecture and IT Infrastructure including Networks, Servers, HMIs, Printers, Scanners, Switches, Firewall rules, Domains, etc.  

• Knowledge of cGMP, GXP, GAMP, SDLC regulations, including 21CFR part 11, and good documentation practices.  

• Knowledge of pharmaceutical, manufacturing and laboratory systems and equipment that support Biologics and clinical manufacturing.  

• Strong technical and problem-solving skills and the ability to work independently.  

• Demonstrated success working in a high-performing, business results-driven environment.  

• Knowledge of Cybersecurity, patching and IT Life Cycle Management (LCM).  

• Understanding of computer system validation.  
• Applies AI to improve team execution and decision‑making

Physical Requirements: 

• Standard office environment coupled with GMP production and facility environment. 

• Must be willing to wear personal protective equipment (PPE) as required. 

• Must be comfortable working with radioactive materials. 

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Indianapolis - RayzeBio - IN: $143,622 - $174,036


The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings athttps://careers.bms.com/benefits

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only:  If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [email protected] with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1607109 : Sr. Mgr, IT - Digital Plant Applications & Infrastructure