Full-Time

Senior Director

Drug Product Development, Small Molecules

Posted on 8/22/2024

Scorpion Therapeutics

Scorpion Therapeutics

51-200 employees

Develops precision oncology treatments for cancer

Biotechnology
Healthcare

Senior, Expert

Boston, MA, USA

Category
Healthcare Administration & Support
Medical, Clinical & Veterinary
Requirements
  • Degree in Pharmaceutical Sciences, Chemistry or Engineering with at least 10 years of life sciences industry experience
  • Expertise in phase-appropriate formulation development and manufacture
  • Knowledge of current Good Manufacturing Practices and experience in leading manufacture under cGMP
  • Strong verbal, written and communications skills as well as a collaborative spirit are essential
  • Direct experience of interactions with CDMOs and manufacturing operations
  • Proven success working in cross-functional teams
  • Strong scientific background and knowledge of the drug development process
  • Experience in the application of scientific tools such as design of experiments (DoE) to facilitate efficient drug development
  • Skill in fostering open communication, mutual understanding, and cooperation
  • Strong understanding of productivity tools, Power Point, Excel, Word along with other related software
  • Experience in managing multiple programs at one time, can work well with different management styles to keep a project moving
  • Competency in developing, implementing, and delivering CMC project plans (milestones, timelines, resources, etc.) to successful endpoints
  • Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and in a cross-functional team environment
  • Experience in developing and commercializing drugs for oncology is an advantage
Responsibilities
  • This role is responsible for the design, optimization, and manufacture of phase-appropriate small molecule drug products to support non-clinical (Discovery support, animal safety studies) and clinical development programs (Phase 1 to commercial).
  • The role also has responsibility for line-of-sight to commercially viable manufacturing processes, including selection of appropriate container closure systems.
  • The role will also provide technical expertise and guidance regarding pre-formulation activities for internal scientists within Scorpion Discovery teams to enable in vivo evaluation of lead compounds by providing.
  • This role will include travel to CDMO sites as required for project meetings, due diligence activities and manufacture.
  • Key member of Project Development Teams, collaborate and partner closely with CMC project management, drug substance SMEs, DMPK/toxicology, clinical operations, regulatory and quality.
  • Execute physico-chemical characterizations, chemical stability assessments, and pre-formulation development activities for small molecule lead compounds.
  • Lead and manage outsourcing activities (formulation/product development and manufacturing) at global CDMO sites, in alignment with program goals.
  • Design drug product R&D and cGMP stability studies to support product development.
  • Act as key product SME for the successful execution of technology transfer of drug product processes to manufacturing site(s), providing technical input/insights to the CDMOs.
  • Create, review, and approve specifications, batch records and other critical development/cGMP documents.
  • Author, review, and complete drug product sections of regulatory documents (IND, IMPD).
  • Foster strong team spirit and promote knowledge exchange within and between teams.
  • Support Discovery with evaluation of dosing solutions, stability studies, outsourcing activities and evaluate novel formulation technologies to assure the most appropriate delivery of compounds for in vivo studies.
  • As a part of the CMC development team, evaluate and select the most suitable physical forms of compounds entering development and define formulation strategies for successful transfer from Discovery to Development.
  • Contribute to evaluation of new scientific technologies and various innovative initiatives within the team.
  • Report and present scientific/technical results internally and contribute to publications, presentations and patents.
Scorpion Therapeutics

Scorpion Therapeutics

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Scorpion Therapeutics develops precision oncology treatments aimed at targeting specific cancer drivers. Their approach involves creating drugs that interact with validated cancer targets, enhancing their selectivity and safety to improve treatment outcomes. Unlike many competitors, Scorpion Therapeutics focuses on forming partnerships with larger pharmaceutical companies for the distribution of their drugs, allowing them to concentrate on research and development. Their goal is to provide effective cancer therapies that can be rapidly deployed to healthcare providers and patients worldwide.

Company Stage

Series C

Total Funding

$408.5M

Headquarters

Boston, Massachusetts

Founded

2020

Growth & Insights
Headcount

6 month growth

6%

1 year growth

13%

2 year growth

44%
Simplify Jobs

Simplify's Take

What believers are saying

  • Raised $150M in Series C funding to advance their oncology pipeline.
  • Partnership with Pierre Fabre for EGFR inhibitors expands market reach in Europe and China.
  • Formation of a Clinical Scientific Advisory Board enhances research and development capabilities.

What critics are saying

  • Leadership changes may impact strategic direction and company morale.
  • Over-reliance on partnerships for revenue could pose financial risks if expectations aren't met.
  • Intense competition in precision oncology may affect market share and pricing power.

What makes Scorpion Therapeutics unique

  • Scorpion Therapeutics focuses on precision medicine for cancer with targeted small-molecule drugs.
  • Their Precision Oncology 2.0 strategy aims to redefine cancer treatment through innovative approaches.
  • Scorpion's STX-478 and STX-721 show potential as best-in-class inhibitors for specific cancer mutations.

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