Full-Time

Research Scientist

AI

Substrate

Substrate

11-50 employees

Develops advanced X-ray lithography chipmaking system

Compensation Overview

$150k - $275k/yr

No H1B Sponsorship

San Francisco, CA, USA

In Person

Category
AI & Machine Learning (2)
,
Required Skills
Python
Tensorflow
Pytorch
Machine Learning
Requirements
  • 5+ years professional or academic research experience in physical sciences, engineering, or related field
  • 2-3+ years hands-on experience applying machine learning to scientific or technical problems
  • Strong programming skills in Python and ML frameworks (PyTorch, TensorFlow, JAX, or similar)
  • Deep understanding of scientific computing, numerical methods, and computational modeling
  • Proven ability to translate scientific problems into machine learning approaches
  • Experience building tools, infrastructure, or capabilities used by technical teams
Responsibilities
  • Integrate machine learning techniques to accelerate scientific simulations, modeling, and computational workflows
  • Develop AI-augmented tools for materials science, device physics, or accelerator physics applications
  • Build internal AI infrastructure and capabilities to enable research teams across the organization
  • Train and mentor scientists and engineers on integrating AI/ML into their research workflows
  • Implement surrogate models, physics-informed neural networks, or generative approaches for scientific problems
  • Develop data pipelines and frameworks for scientific machine learning across distributed teams
  • Collaborate with computational physicists and experimentalists to identify high-impact AI applications
  • Set AI best practices and establish standards for ML-augmented R&D
Desired Qualifications
  • PhD in Physics, Materials Science, Computer Science, Applied Mathematics, or related field
  • Publications applying ML to scientific computing, simulation, or experimental data analysis
  • Experience with physics-informed machine learning or scientific foundation models
  • Background in accelerator physics, semiconductor devices, materials modeling, or related domains
  • Track record of enabling technical teams through tool development or mentorship

Substrate is developing a new chipmaking system that uses X-ray lithography powered by a proprietary particle accelerator to pattern circuits on silicon wafers. The technology aims to lower lithography costs by about half and is demonstrated at U.S. National Laboratories and in its own facilities. It differentiates itself by pursuing a more vertically integrated U.S. foundry to reduce reliance on overseas fabrication and strengthen supply-chain resilience. The goal is to produce its first chips by 2028 and help bring advanced AI and robotics chips manufacturing back to the United States.

Company Size

11-50

Company Stage

Late Stage VC

Total Funding

$100M

Headquarters

San Francisco, California

Founded

2022

Simplify Jobs

Simplify's Take

What believers are saying

  • Secured $100M funding at $1B valuation from Founders Fund, General Catalyst.
  • Plans $10K wafers by 2030, halving costs versus EUV systems.
  • Met VP JD Vance in March 2025 to cut U.S. semiconductor costs.

What critics are saying

  • ASML's High-NA EUV scales to 2nm by 2028, outpacing Substrate.
  • Particle accelerators fail high-volume due to G-force instability.
  • CEO Proud's non-expertise repeats Intel's 1990s X-ray failures.

What makes Substrate unique

  • Substrate develops particle accelerator-based X-ray lithography rivaling ASML.
  • Vertically integrated U.S. foundry targets AI and robotics chip production.
  • Completed 300mm wafer tool operating at production G-forces in-house.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Health Savings Account/Flexible Spending Account

Unlimited Paid Time Off

Flexible Work Hours

Remote Work Options

Paid Vacation

Paid Sick Leave

Paid Holidays

Hybrid Work Options

Stock Options

401(k) Retirement Plan

Wellness Program

Mental Health Support

Gym Membership

Phone/Internet Stipend

Home Office Stipend

Corporate Social Events

Company News

Financial Times
Oct 28th, 2025
Silicon Valley chip start-up raises $100mn to take on TSMC and ASML

Substrate plans to use particle accelerators to lower cost of chip manufacturing