Pattern Biosciences

Rapid bacterial ID and susceptibility testing

In vivo Scientist - Oncology

Translational Research & Bench BiologyConfirmed live in the last 24 hours

Full-timeSouth San Francisco, CA, USANo salary listed

About the Job

Requirements

PhD in Life Sciences with specialization in oncology or immunology.
At least 3 years of hands-on experience working with murine tumor models in an industry and/or academic setting.
Ability to independently design, execute, and interpret experimental data.
Experience with in vivo procedures, such as rodent surgery and intravenous dosing.
Experience with tissue handling and processing, cell sorting, multicolor flow cytometry, and cytokine profiling.
Proficiency in mammalian cell and tissue culture.
Strong organizational and record-keeping skills.
Ability to collaborate effectively in a cross-functional team.

Responsibilities

Design and execute in vivo studies in various preclinical tumor models to evaluate the mechanism of action, efficacy, and safety of therapeutic candidates.
Perform in vivo procedures, such as orthotopic tumor implantation, intravenous and intraperitoneal injections, blood sampling, in vivo imaging, and animal welfare monitoring.
Perform necropsy, tissue collection and processing for immunohistochemistry or histopathology, tissue dissociation, and cell sorting via magnetic-activated cell sorting or fluorescence-activated cell sorting for downstream tumor-cell-based or immune-cell-based assays.
Conduct immune cell profiling using multicolor flow cytometry, and cytokine/chemokine analysis using enzyme-linked immunosorbent assay and Luminex.
Generate, document, analyze, and interpret experimental data to support critical decisions on lead candidates.
Manage external laboratories and partners.

Desired Qualifications

Experience with immunohistochemistry and in situ hybridization.
Experience working in a good laboratory practice or regulatory-compliant environment.

About Pattern Biosciences

At Pantheon Bio, we build DNA computers that run molecular programs in cells to treat cancer and other diseases. Using multi-input molecular-level computation in individual cells, our approach leads to curative therapies where the conventional one drug-one target paradigm has failed to deliver effective treatments. We are building a world-class team at our headquarters in South San Francisco to translate two decades of scientific progress in DNA computing and synthetic biology into the clinic.

About the role

You will design and execute in vivo mouse studies of AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to preclinical study design and lead their execution, ensuring high levels of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in immuno-oncology and in vivo pharmacology who thrives in a team-oriented, cross-disciplinary collaborative environment.

Key responsibilities

Design and execute in vivo studies in various preclinical tumor models to evaluate the mechanism of action, efficacy and safety of therapeutic candidates
Perform in vivo procedures, such as orthotopic tumor implantation, IV and IP injections, blood sampling, in vivo imaging, and animal welfare monitoring
Perform necropsy, tissue collection and processing for IHC or histopathology, tissue dissociation and cell sorting via MACS/FACS for downstream tumor cell-based or immune cell-based assays
Conduct immune cell profiling using multicolor flow cytometry, and cytokine/chemokine analysis using ELISA and Luminex
Generate, document, analyze and interpret experimental data to support critical decisions on the lead candidates
Manage external laboratories and partners

Who you are

PhD in Life Sciences with specialization in oncology or immunology
At least 3 years of hands-on experience working with murine tumor models in an industry and/or academic setting
Demonstrated independent ability to design, execute and interpret experimental data
Demonstrated experience in in vivo procedures, such as rodent surgery and IV dosing
Experience with tissue handling and processing, cell sorting, multi-color flow cytometry and cytokine profiling, experience with IHC and ISH is a plus
Proficiency in mammalian cell and tissue culture
Detail-oriented, with strong organizational and record-keeping skills
Excellent communication skills and ability to collaborate effectively in a cross-functional team
Experience working in a GLP or regulatory-compliant environment is a plus

To apply, please submit a cover letter and a detailed CV to [email protected]

About the Company

Pattern Biosciences

Rapid bacterial ID and susceptibility testing

Pattern Biosciences develops an in-vitro diagnostics platform for rapid bacterial identification and antibiotic susceptibility testing. It combines single-cell analysis with machine learning; an instrument and proprietary test kits process a clinical sample to identify the pathogen and predict the most effective antibiotic within hours. Unlike traditional methods that take days, this approach speeds up actionable results and uses data from single cells plus ML, with revenue from instrument sales plus consumables. Its goal is to improve patient outcomes, reduce healthcare costs, and help preserve antibiotic effectiveness by enabling faster, more accurate treatment decisions.

Company size: 11-50
Company stage: Grant
Total funding: $60K
Headquarters: South San Francisco, CA
Founded: 2018

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