Senior Medical Director

The Position

At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Medical Director to join our Clinical Sciences team and take a central role in pioneering the future of healthcare.

As a Senior Medical Director,you'll be at the forefront of translating genetic insights into innovative treatments for patients. Your work will help drive the clinical development programs for game-changing therapies, starting with a small molecule that targets SLC6A19 – a novel therapeutic target for the treatment of chronic kidney disease and phenylketonuria.

Maze Therapeutics has an exciting pipeline spanning both rare and common renal, cardiac, and metabolic diseases. In short, you'll play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives. 

To succeed in this role, you'll need to thrive in a fast-paced, collaborative environment. As a Senior Medical Director for one or more development programs, you will partner closely with cross-functional team members and other technical experts to design, conduct, and interpret the key clinical studies, including first-in-human and proof-of-concept trials. Your contributions will be highly visible and integral to the success of the Maze team.

This position reports to the Head of Clinical Development.

The Impact You’ll Have

• Lead the design, execution, and analysis ofclinical trials for the SLC6A19 program and other early-stage clinicalassets at Maze
• Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs  
• Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators.
• Engage with scientific thought leaders and patient advocacy groupsto gain insights to inform clinical development plans and build awareness and enthusiasm for the Maze pipeline assets.
• Partner with Clinical Development Operations to identify and select study investigators and sites and build strong professional relationships with study investigators.
• Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs.
• Develop and integrate timelines and budgets for clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders.

As a Senior Director, we also expect our leaders to demonstrate the following Leadership Competencies:

• Communication and Influence
  • Builds communication channels across Maze for sharing information.
  • Influences Senior Management decisions through persuasive arguments.
  • Respectfully addresses differing opinions leading to support of decisions.
• Teamwork and Collaboration
  • Champions partnerships and connections across Maze.
  • Proactively addresses issues that could result in breakdown of team relationships.
  • Spotlights team and individual contributions in public forums.
• Execution and Results
  • Addresses gaps and leverages strengths to get best results.
  • Maintains a steadying presence and clarifies priorities during change.
  • Anticipates and removes barriers that put functional/corporate goals at risk.
• Develop Others and Self
  • Remove barriers to staff development and empowers them to make their own decisions.
  • Stays current on industry trends and keeps direct-reports prepared and responsive.

What We’re Looking For

• MD with 6+ years of drug development industry experience.  
• Board eligibility/certification and clinical experience in internal medicine and/or pediatrics. Additional clinical or research experience in nephrology or cardiometabolic diseases is preferred.
• Experience as a clinical study medical monitor 
• Experience with the preparation and submission of scientific publications, study protocols, Investigator Brochures, and other clinical-regulatory documents.
• Experience in the planning and oversight of early-stage and/or registration-enabling clinical development programs including CRO and site selection and relationship building with investigators/site study staff, patient advocacy groups, and other third parties 
• Demonstrated knowledge and experience in the design and conduct of clinical trials and clinical data analysis and interpretation, particularly Phase 2 trials.
• Experience leading a cross-functional study team.
• Committed to nurturing relationships with investigators, site study staff, patient advocacy groups, and other third parties to support the clinical programs and broader Maze objectives.
• Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high-quality data on time and within budget.
• A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals.
• Willingness to travel domestically and internationally (up to20%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings.­

This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week.   

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

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The expected annual salary range for employees located in the San Francisco Bay Area is $337,500 - 412,500. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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