REGENXBIO

Develops AAV gene delivery therapies

Senior Director – Global Program Development Lead - DMD/Neuromuscular

Biology & BiotechConfirmed live in the last 24 hours

Full-timeRockville, MD, USA

About the Job

Requirements

A bachelor's degree is required; an advanced degree (MS, PhD, or MBA) in a life sciences or healthcare field is preferred.
At least 8 years of pharmaceutical industry leadership experience, with a strong track record of driving drug development programs through pivotal stages to commercialization.
A strong understanding of drug development and commercialization processes, ideally within rare disease or gene therapy.
The ability to work effectively under intense pressure, tight timelines, and rapidly changing conditions.
An entrepreneurial approach and the ability to find creative solutions to unexpected hurdles.
The ability to interact effectively across teams and supporting functions through influencing, communication, and relationship-building skills.
A commitment to anticipating, influencing, and directing change.
Strong listening and collaboration skills.

Responsibilities

Lead overall program strategy and be accountable for an integrated Program Development Strategy, Target Product Profile, and lifecycle management plan aligned with corporate objectives and portfolio goals to maximize asset value.
Drive cross-functional strategic integration, ensuring scientific rigor, emerging clinical data, competitive intelligence, and market dynamics inform program direction and decisions.
Identify development challenges and define strategic options across functions, including timelines, budgets, risks, and trade-offs, to support timely, high-quality decision-making.
Support business development activities, including opportunity assessment and due diligence, and represent partnered assets on Joint Steering Committees.
Engage key opinion leaders, patient advocacy groups, and external experts to maintain an external perspective and scientific credibility.
Develop and mature the program's external communications strategy with relevant groups, including scientific messaging, competitive positioning, and stakeholder alignment.
Drive cross-functional program execution within a matrix organization, ensuring high-quality, on-time deliverables, aligned priorities and resources, and proactive resolution of critical challenges.
Anticipate operational and strategic risks, establish contingency plans, and pressure-test assumptions, timelines, and budgets to maintain program agility and support informed decisions.
Serve as the primary liaison between the Core Team and governance committees, presenting program materials and data-driven recommendations to support timely approvals.
Build, influence, and sustain high-performing teams, guiding complex decisions without direct authority.
Lead cross-functional teams to deliver program outcomes, challenge assumptions, timelines, and budgets, and develop alternative scenarios to mitigate risk and maximize value.
Own the quality, integrity, and timeliness of team outputs; ensure company decisions are informed by robust data and set pace and priorities to achieve milestones.
Serve as the program spokesperson, aligning stakeholders and communicating strategy, progress, and decisions to internal and external audiences.
Foster innovation, scientific rigor, creative problem-solving, collaboration, and continuous improvement.
Coach and develop team members to support performance, accountability, skill growth, and collective achievement.
Lead through ambiguity and drive complex drug development decisions in fast-paced environments.
Travel up to 20%.
Work collaboratively, build strong relationships, and communicate clearly to meet shared objectives.

Desired Qualifications

Product launch and early commercialization experience is a strong plus.
Deep knowledge of neuromuscular diseases is highly desirable.

Who we are

REGENXBIO is an exceptional place to work. You'll have the opportunity to collaborate with some of the best and the brightest people, touch amazing science, and be a part of extraordinary plans. Our core values: Trust, Accountability, Perseverance, and Innovation drive everything we do. We aim to bring these values to life every day with all that we do, and we believe that what we do matters - to patients, to their families, and to their communities.

The opportunity

As a Senior Director, Global Program Development Lead (PDL), you will be in a highly visible leadership role that sits at the center of the cross-functional program team, to shape a compelling strategic direction, set ambitious priorities, and drive disciplined execution, in partnership with senior leadership. Leveraging deep expertise in drug development and commercialization, along with a forward-looking perspective and strong operational mindset, you will ensure the program team operates with clarity, rigor, and urgency while fostering collaboration and high performance. Accountable for cross-functional outputs, you'll guide the program’s path forward by anticipating opportunities, mitigating risks, cultivating strategic options, and driving decision-making amid complexity and uncertainty to achieve long-term program success.

What you'll be doing

Lead overall program strategy, accountable for an integrated Program Development Strategy, Target Product Profile (TPP), and lifecycle management plan aligned with corporate objectives and long-term portfolio goals to maximize asset value.
Drive cross-functional strategic integration, ensuring scientific rigor and emerging clinical data, competitive intelligence, and evolving market dynamics inform program direction and critical decisions.
Identify key development challenges and define strategic options across functions, including timelines, budgets, risks, and trade-offs, enabling timely, high-quality decision-making.
Support business development activities, including opportunity assessment and due diligence; represent the program on Joint Steering Committees for partnered assets.
Maintain external perspective and scientific credibility through engagement with KOLs, patient advocacy groups, and other external experts.
Evolving and maturing the program’s external communications strategy in partnership with key groups, including the elements of scientific messaging, competitive positioning, and stakeholder alignment.
Drive cross-functional program execution within a matrix organization, ensuring high-quality, on-time deliverables while aligning priorities and resources to maximize program value and proactively resolve critical challenges.
Anticipate operational and strategic risks, establish contingency plans, and pressure-test assumptions, timelines, and budgets to maintain program agility and informed decision-making.
Serve as the primary liaison between the Core Team and governance committees, presenting program materials with clear, data-driven recommendations and actionable options to support timely approvals.
Build, influence, and sustain high-performing teams, guiding complex, high-stakes decisions without direct authority.
Lead cross-functional teams to deliver high-impact program outcomes, challenging assumptions, timelines, and budgets while developing alternative scenarios to mitigate risk and maximize value.
Own the quality, integrity, and timeliness of team outputs, ensuring company-level decisions are informed by robust, high-caliber data; set pace and priorities to achieve milestones in a highly competitive landscape.
Serve as the program spokesperson, aligning stakeholders and communicating strategy, progress, and decisions clearly across internal and external audiences.
Inspire innovation, scientific rigor, and creative problem-solving, fostering a culture of collaboration, continuous improvement, and boundary-less thinking.
Coach and develop team members to achieve peak performance, cultivating accountability, skill growth, and collective achievement.
Lead with pragmatism and clarity through ambiguity, charting the path forward and driving complex drug development decisions in fast-paced, dynamic environments.
Travel up to 20%
It is imperative that REGENXBIO employees embody our core values by working collaboratively, building strong relationships and using clear communication to meet shared objectives.

What we're looking for

Bachelor’s degree required; advanced degree (MS, PhD, MBA) in life sciences or healthcare field preferred.
Proven leader with 8+ years in pharmaceutical industry leadership, with a strong track record driving drug development programs through pivotal stages to commercialization; product launch and early commercialization experience is a strong plus.
Strong understanding of drug development and commercialization processes, ideally within rare disease or gene therapy
Deep knowledge of neuromuscular diseases is highly desirable.
The ability to work well under intense pressure, tight timelines, and in rapidly changing situations
Evidence of an entrepreneurial spirit and a capacity to find creative solutions to unexpected hurdles
Interacts effectively across teams with supporting REGENXBIO functions and disciplines using influencing, communication and relationship building skills
Commitment to anticipate, influence and direct change
Excellent listening and collaboration skills

Why should you apply?

By joining REGENXBIO, you will have the opportunity to be a part of a growing company, with an incredible team, who is passionate about developing novel AAV gene therapies for patients in need.

We offer a comprehensive and competitive benefit & compensation package which includes market-competitive salaries, an annual bonus program, education assistance, retirement plan with employer match, stock options at all levels, summer hours and more! The estimated compensation range for this role is $235,000 to $335,000 annually. The actual salary offered to the final candidate depends on a number of factors such as relevant work experience, skills, education, and years of experience.

In addition, professional development is important to us. By joining our team, you’ll have the opportunity to be exposed to challenging projects and have access to development resources to help you grow personally and professionally.

About the Company

REGENXBIO

Develops AAV gene delivery therapies

REGENXBIO focuses on gene therapy using its NAV Technology Platform, an adeno-associated virus (AAV) gene delivery system with exclusive rights to more than 100 AAV vectors. The company generates revenue by licensing its platform, collecting royalties, and engaging in collaborations, while also developing its own one-time gene therapies for retinal, rare, and neurodegenerative diseases. Key products in later-stage trials include ABBV-RGX-314 for wet AMD and diabetic retinopathy, RGX-202 for Duchenne muscular dystrophy, and RGX-121 for Hunter syndrome, with a goal to advance five new therapies to pivotal-stage or commercial status by 2025 and FDA review for RGX-121 targeted in early 2026. REGENXBIO differentiates itself by owning a broad AAV vector library and offering end-to-end capabilities—from research to manufacturing—alongside a diversified revenue model that includes royalties, collaborations, and milestones.

Company size: 201-500
Company stage: IPO
Headquarters: Rockville, MD
Founded: 2009

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